Department of Cellular and Molecular Medicine
David S. Park has not added Biography.
If you are David S. Park and would like to personalize this page please email our Author Liaison for assistance.
Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities.
The Journal of biological chemistry Mar, 2002 | Pubmed ID: 11739396
Caveolin-1 expression enhances endothelial capillary tubule formation.
The Journal of biological chemistry Mar, 2002 | Pubmed ID: 11748236
Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Feb, 2002 | Pubmed ID: 11823715
Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype.
The American journal of pathology Jun, 2002 | Pubmed ID: 12057923
Molecular cloning and developmental expression of the caveolin gene family in the amphibian Xenopus laevis.
Biochemistry Jun, 2002 | Pubmed ID: 12069580
Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage.
The Journal of biological chemistry Sep, 2002 | Pubmed ID: 12091388
Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.
The Journal of biological chemistry Sep, 2002 | Pubmed ID: 12091389
Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development.
The EMBO journal Jul, 2002 | Pubmed ID: 12093735
Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade.
The Journal of biological chemistry Oct, 2002 | Pubmed ID: 12138167
Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death.
The Journal of cell biology Aug, 2002 | Pubmed ID: 12147675
Cyclin-dependent kinases as potential targets to improve stroke outcome.
Pharmacology & therapeutics Feb-Mar, 2002 | Pubmed ID: 12191606
Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis.
The Journal of biological chemistry Dec, 2002 | Pubmed ID: 12351630
Constitutive nuclear factor-kappa B activity is required for central neuron survival.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2002 | Pubmed ID: 12351721
Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia.
The American journal of pathology Oct, 2002 | Pubmed ID: 12368209
Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts.
American journal of physiology. Cell physiology Feb, 2003 | Pubmed ID: 12388077
Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade.
Molecular biology of the cell Oct, 2002 | Pubmed ID: 12388746
Glomerular endothelial fenestrae in vivo are not formed from caveolae.
Journal of the American Society of Nephrology : JASN Nov, 2002 | Pubmed ID: 12397033
Cyclin-dependent kinases and stroke.
Expert opinion on therapeutic targets Oct, 2001 | Pubmed ID: 12540283
Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2003 | Pubmed ID: 12598612
Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice.
Molecular biology of the cell Mar, 2003 | Pubmed ID: 12631721
Caveolin, caveolae, and endothelial cell function.
Arteriosclerosis, thrombosis, and vascular biology Jul, 2003 | Pubmed ID: 12689915
Calpains mediate p53 activation and neuronal death evoked by DNA damage.
The Journal of biological chemistry Jul, 2003 | Pubmed ID: 12721303
Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2003 | Pubmed ID: 12764095
Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.
The Journal of biological chemistry Sep, 2003 | Pubmed ID: 12857758
Proteasome inhibitor (MG-132) treatment of mdx mice rescues the expression and membrane localization of dystrophin and dystrophin-associated proteins.
The American journal of pathology Oct, 2003 | Pubmed ID: 14507673
Genetic ablation of caveolin-1 confers protection against atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology Jan, 2004 | Pubmed ID: 14563650
Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2003 | Pubmed ID: 14595022
Caveolin-1 null (-/-) mice show dramatic reductions in life span.
Biochemistry Dec, 2003 | Pubmed ID: 14690422
Emerging pathogenic role for cyclin dependent kinases in neurodegeneration.
Cell cycle (Georgetown, Tex.) Mar, 2004 | Pubmed ID: 14726693
Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2004 | Pubmed ID: 14985447
Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2004 | Pubmed ID: 15044535
The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1.
The Journal of biological chemistry Jul, 2004 | Pubmed ID: 15105421
CDKs: taking on a role as mediators of dopaminergic loss in Parkinson's disease.
Trends in molecular medicine Sep, 2004 | Pubmed ID: 15350897
p107 regulates neural precursor cells in the mammalian brain.
The Journal of cell biology Sep, 2004 | Pubmed ID: 15353549
p53 activation domain 1 is essential for PUMA upregulation and p53-mediated neuronal cell death.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2004 | Pubmed ID: 15525786
c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation.
The Journal of biological chemistry Jan, 2005 | Pubmed ID: 15528206
Comparison of rectilinear biphasic waveform energy versus truncated exponential biphasic waveform energy for transthoracic cardioversion of atrial fibrillation.
The American journal of cardiology Dec, 2004 | Pubmed ID: 15566922
BAG5 inhibits parkin and enhances dopaminergic neuron degeneration.
Neuron Dec, 2004 | Pubmed ID: 15603737
Apoptosis-inducing factor is a key factor in neuronal cell death propagated by BAX-dependent and BAX-independent mechanisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2005 | Pubmed ID: 15703386
MR imaging of caveolin gene-specific alterations in right ventricular wall thickness.
Magnetic resonance imaging Jan, 2005 | Pubmed ID: 15733789
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2005 | Pubmed ID: 15784737
Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2005 | Pubmed ID: 16166266
Differential roles of nuclear and cytoplasmic cyclin-dependent kinase 5 in apoptotic and excitotoxic neuronal death.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2005 | Pubmed ID: 16192386
Apical role for BRG1 in cytokine-induced promoter assembly.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2005 | Pubmed ID: 16195385
MPTP induces intranuclear rodlet formation in midbrain dopaminergic neurons.
Brain research Dec, 2005 | Pubmed ID: 16325158
Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase.
Journal of neurochemistry Jan, 2006 | Pubmed ID: 16336220
Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2006 | Pubmed ID: 16407541
NFkappaB in neurons? The uncertainty principle in neurobiology.
Journal of neurochemistry May, 2006 | Pubmed ID: 16573643
Caveolin-1 and regulation of cellular cholesterol homeostasis.
American journal of physiology. Heart and circulatory physiology Aug, 2006 | Pubmed ID: 16603689
Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis.
The EMBO journal Sep, 2006 | Pubmed ID: 16917506
The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin.
The Journal of neuroscience : the official journal of the Society for Neuroscience Aug, 2006 | Pubmed ID: 16928871
Role of cyclooxygenase-2 induction by transcription factor Sp1 and Sp3 in neuronal oxidative and DNA damage response.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Nov, 2006 | Pubmed ID: 17012241
Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2007 | Pubmed ID: 17376993
Unique requirement for Rb/E2F3 in neuronal migration: evidence for cell cycle-independent functions.
Molecular and cellular biology Jul, 2007 | Pubmed ID: 17452454
Mitofusin 2 protects cerebellar granule neurons against injury-induced cell death.
The Journal of biological chemistry Aug, 2007 | Pubmed ID: 17537722
Cell cycle regulator E2F4 is essential for the development of the ventral telencephalon.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2007 | Pubmed ID: 17537963
The Retinoblastoma family member p107 regulates the rate of progenitor commitment to a neuronal fate.
The Journal of cell biology Jul, 2007 | Pubmed ID: 17591923
The nuclear localization of SET mediated by impalpha3/impbeta attenuates its cytosolic toxicity in neurons.
Journal of neurochemistry Oct, 2007 | Pubmed ID: 17608644
Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease.
Neuron Jul, 2007 | Pubmed ID: 17610816
Required roles of Bax and JNKs in central and peripheral nervous system death of retinoblastoma-deficient mice.
The Journal of biological chemistry Jan, 2008 | Pubmed ID: 17984095
The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2007 | Pubmed ID: 18003894
Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia.
Journal of neurochemistry May, 2008 | Pubmed ID: 18205749
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2008 | Pubmed ID: 18218782
CITED2 signals through peroxisome proliferator-activated receptor-gamma to regulate death of cortical neurons after DNA damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2008 | Pubmed ID: 18495890
Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2008 | Pubmed ID: 18550749
DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2009 | Pubmed ID: 19144925
E2F4 is required for early eye patterning.
Developmental neuroscience , 2009 | Pubmed ID: 19325228
Parkinson's disease: to live or die by autophagy.
Science signaling , 2009 | Pubmed ID: 19351953
The p107/E2F pathway regulates fibroblast growth factor 2 responsiveness in neural precursor cells.
Molecular and cellular biology Sep, 2009 | Pubmed ID: 19564414
Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease.
Human molecular genetics Nov, 2009 | Pubmed ID: 19692353
Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2009 | Pubmed ID: 19812325
Pim-1 kinase as activator of the cell cycle pathway in neuronal death induced by DNA damage.
Journal of neurochemistry Jan, 2010 | Pubmed ID: 19895669
Amyloid-beta42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2009 | Pubmed ID: 19926863
DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2010 | Pubmed ID: 20133695
Sertad1 plays an essential role in developmental and pathological neuron death.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2010 | Pubmed ID: 20237268
The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death.
Nature cell biology Jun, 2010 | Pubmed ID: 20473298
Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.
Human molecular genetics Oct, 2010 | Pubmed ID: 20624856
Cdk5: Links to DNA damage.
Cell cycle (Georgetown, Tex.) Aug, 2010 | Pubmed ID: 20724832
The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity.
The Journal of biological chemistry Feb, 2011 | Pubmed ID: 21041314
Rb/E2F regulates expression of neogenin during neuronal migration.
Molecular and cellular biology Jan, 2011 | Pubmed ID: 21059867
MCL-1 is a stress sensor that regulates autophagy in a developmentally regulated manner.
The EMBO journal Jan, 2011 | Pubmed ID: 21139567
Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2010 | Pubmed ID: 21159964
The cardiac conduction system.
Circulation Mar, 2011 | Pubmed ID: 21357845
Structural and functional analyses of a glycoside hydrolase family 5 enzyme with an unexpected β-fucosidase activity.
Biochemistry Apr, 2011 | Pubmed ID: 21410228
Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1.
Oncology reports Jun, 2011 | Pubmed ID: 21479363
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.
Journal of neural transmission (Vienna, Austria : 1996) May, 2011 | Pubmed ID: 21552986
Involvement of the Fc gamma receptor in a chronic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of dopaminergic loss.
The Journal of biological chemistry Aug, 2011 | Pubmed ID: 21693708
Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system.
Human molecular genetics Feb, 2012 | Pubmed ID: 22076440
Animal models of Parkinson's disease.
Parkinson's disease , 2011 | Pubmed ID: 22220287
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment.
EMBO reports Apr, 2012 | Pubmed ID: 22354088
Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1.
The Journal of biological chemistry Jun, 2012 | Pubmed ID: 22511790
Forever young: induced pluripotent stem cells as models of inherited arrhythmias.
Circulation Jun, 2012 | Pubmed ID: 22647977
The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2012 | Pubmed ID: 22699903
ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons.
Human molecular genetics Nov, 2012 | Pubmed ID: 22872702
Programmed cell death in Parkinson's disease.
Cold Spring Harbor perspectives in medicine , 2012 | Pubmed ID: 22908196
Progressive dopaminergic cell loss with unilateral-to-bilateral progression in a genetic model of Parkinson disease.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2012 | Pubmed ID: 23019375
The retinoblastoma protein is essential for survival of postmitotic neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Oct, 2012 | Pubmed ID: 23077065
LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction.
Human molecular genetics Mar, 2013 | Pubmed ID: 23187960
Cardiovascular dysregulation of miR-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Apr, 2013 | Pubmed ID: 23271053
Opposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells.
Cell stem cell Apr, 2013 | Pubmed ID: 23499385
Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2013 | Pubmed ID: 23536090
Perturbation of transcription factor Nur77 expression mediated by myocyte enhancer factor 2D (MEF2D) regulates dopaminergic neuron loss in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
The Journal of biological chemistry May, 2013 | Pubmed ID: 23536182
LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence.
Cell cycle (Georgetown, Tex.) May, 2013 | Pubmed ID: 23574720
The funny and not-so-funny effects of dronedarone.
Heart rhythm : the official journal of the Heart Rhythm Society Nov, 2013 | Pubmed ID: 23973951
Pocket proteins critically regulate cell cycle exit of the trabecular myocardium and the ventricular conduction system.
Biology open , 2013 | Pubmed ID: 24143284
Nav-igating through a complex landscape: SCN10A and cardiac conduction.
The Journal of clinical investigation Apr, 2014 | Pubmed ID: 24642462
Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival.
Nature communications , 2014 | Pubmed ID: 24686499
Unaltered striatal dopamine release levels in young Parkin knockout, Pink1 knockout, DJ-1 knockout and LRRK2 R1441G transgenic mice.
PloS one , 2014 | Pubmed ID: 24733019
Regulation of ischemic neuronal death by E2F4-p130 protein complexes.
The Journal of biological chemistry Jun, 2014 | Pubmed ID: 24828495
Triple alternans during a tachycardia--what is the mechanism?
Heart rhythm : the official journal of the Heart Rhythm Society Sep, 2014 | Pubmed ID: 24846375
Regulation of the VHL/HIF-1 pathway by DJ-1.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2014 | Pubmed ID: 24899725
Preexcitation on surface ECG: Where is the accessory pathway?
Heart rhythm : the official journal of the Heart Rhythm Society Nov, 2014 | Pubmed ID: 24997403
DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress.
PloS one , 2014 | Pubmed ID: 25210784
OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand.
The EMBO journal Nov, 2014 | Pubmed ID: 25298396
Genetically engineered SCN5A mutant pig hearts exhibit conduction defects and arrhythmias.
The Journal of clinical investigation Dec, 2014 | Pubmed ID: 25500882
SOBRE A JoVE
Copyright © 2024 MyJoVE Corporation. Todos os direitos reservados