Ann F. Chambers

Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences.

Activated ras regulates the proliferation/apoptosis balance and early survival of developing micrometastases.

Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy.

Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling.

Dissemination and growth of cancer cells in metastatic sites.

Plasma osteopontin: associations with survival and metastasis to bone in men with hormone-refractory prostate carcinoma.

Cancer spread and micrometastasis development: quantitative approaches for in vivo models.

Osteopontin-induced migration of human mammary epithelial cells involves activation of EGF receptor and multiple signal transduction pathways.

Transcriptional regulation of osteopontin and the metastatic phenotype: evidence for a Ras-activated enhancer in the human OPN promoter.

Osteopontin and colon cancer progression.

Osteopontin (Eta-1) and fibroblast growth factor-2 cross-talk in angiogenesis.

Estrous cycle influences organ-specific metastasis of B16F10 melanoma cells.

Beta(3) integrin expression increases breast carcinoma cell responsiveness to the malignancy-enhancing effects of osteopontin.

The role of apoptosis in tumor progression and metastasis.

Evaluating the role of serine protease inhibition in the management of tumor micrometastases.

Ineffectiveness of doxorubicin treatment on solitary dormant mammary carcinoma cells or late-developing metastases.

Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies.

Osteopontin identified as colon cancer tumor progression marker.

Surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS): a new proteomic urinary test for patients with urolithiasis.

A flavonoid fraction from cranberry extract inhibits proliferation of human tumor cell lines.

Mapping of the functional microcirculation in vital organs using contrast-enhanced in vivo video microscopy.

In vivo videomicroscopy reveals differential effects of the vascular-targeting agent ZD6126 and the anti-angiogenic agent ZD6474 on vascular function in a liver metastasis model.

Therapeutic targets for antimetastatic therapy.

Detection and quantification of circulating tumor cells in mouse models of human breast cancer using immunomagnetic enrichment and multiparameter flow cytometry.

Dietary genistein reduces metastasis in a postsurgical orthotopic breast cancer model.

Osteopontin induces multiple changes in gene expression that reflect the six "hallmarks of cancer" in a model of breast cancer progression.

Three-dimensional high-frequency ultrasound imaging for longitudinal evaluation of liver metastases in preclinical models.

Re: Medroxyprogesterone acetate and metastases: of mice and (wo)men.

Plasma osteopontin levels are predictive of disease stage in patients with transitional cell carcinoma of the bladder.

A new model for lymphatic metastasis: development of a variant of the MDA-MB-468 human breast cancer cell line that aggressively metastasizes to lymph nodes.

Expression of osteopontin and HGF/met in adult soft tissue tumors.

In vivo magnetic resonance imaging of single cells in mouse brain with optical validation.

Ovarian cancer biomarkers in urine.

Time-course characterization of the computed tomography contrast enhancement of an iodinated blood-pool contrast agent in mice using a volumetric flat-panel equipped computed tomography scanner.

Enhanced cell surface CD44 variant (v6, v9) expression by osteopontin in breast cancer epithelial cells facilitates tumor cell migration: novel post-transcriptional, post-translational regulation.

Serial plasma osteopontin levels have prognostic value in metastatic breast cancer.

Molecular mechanisms of metastasis.

Osteopontin induction of hyaluronan synthase 2 expression promotes breast cancer malignancy.

Role of the integrin-binding protein osteopontin in lymphatic metastasis of breast cancer.

Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435.

Dormancy of solitary metastatic cells.

Breast cancer metastasis progression as revealed by intravital videomicroscopy.

Tumor dormancy and the role of metastasis suppressor genes in regulating ectopic growth.

In vivo MRI of cancer cell fate at the single-cell level in a mouse model of breast cancer metastasis to the brain.

In vivo inhibition of growth of human tumor lines by flavonoid fractions from cranberry extract.

Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-kappaB activation.

The biology of metastasis to a sanctuary site.

Tumor dormancy and cancer stem cells: implications for the biology and treatment of breast cancer metastasis.

Brain metastases of breast cancer.

Tumour dormancy in breast cancer: an update.

Osteopontin overexpression in breast cancer: knowledge gained and possible implications for clinical management.

Osteopontin expression in normal skin and non-melanoma skin tumors.

A new breast cancer model for lymphatic metastasis.

Myxoma virus oncolysis of primary and metastatic B16F10 mouse tumors in vivo.

The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms.

Noninvasive quantification of tumor volume in preclinical liver metastasis models using contrast-enhanced x-ray computed tomography.

Experimental metastasis assays in the chick embryo.

Molecular cytogenetic characterization of human breast cancer cell line MDA-MB-468 and its variant 468LN, which displays aggressive lymphatic metastasis.

Influence of diet on metastasis and tumor dormancy.

Changes over time of extracellular domain of HER2 (ECD/HER2) serum levels have prognostic value in metastatic breast cancer.

Downregulation of osteopontin contributes to metastasis suppression by breast cancer metastasis suppressor 1.

BRMS1 suppresses breast cancer metastasis in multiple experimental models of metastasis by reducing solitary cell survival and inhibiting growth initiation.

Contrast-enhanced microcomputed tomography using intraperitoneal contrast injection for the assessment of tumor-burden in liver metastasis models.

Ex-vivo cellular MRI with b-SSFP: quantitative benefits of 3T over 1.5 T.

Epigenetic mapping and functional analysis in a breast cancer metastasis model using whole-genome promoter tiling microarrays.

Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton.

Distinct karyotypes in three breast cancer cell lines --21PTCi, 21NTCi, and 21MT-1 --derived from the same patient and representing different stages of tumor progression.

New clinical and experimental approaches for studying tumor dormancy: does tumor dormancy offer a therapeutic target?

Introduction to special issue on 'epigenetic and physiological regulation of metastasis'.

Chapter 9. Intravital videomicroscopy in angiogenesis research.

Effect of anti-fibrinolytic therapy on experimental melanoma metastasis.

Putative growth characteristics of micrometastatic breast cancer.

New dual monoclonal ELISA for measuring plasma osteopontin as a biomarker associated with survival in prostate cancer: clinical validation and comparison of multiple ELISAs.

MDA-MB-435 and M14 cell lines: identical but not M14 melanoma?

Lymphatic metastasis of breast cancer cells is associated with differential gene expression profiles that predict cancer stem cell-like properties and the ability to survive, establish and grow in a foreign environment.

Tumor dormancy and metastasis.

Micrometastatic disease and metastatic outgrowth: clinical issues and experimental approaches.

Three-dimensional imaging and quantification of both solitary cells and metastases in whole mouse liver by magnetic resonance imaging.

Multi-platform whole-genome microarray analyses refine the epigenetic signature of breast cancer metastasis with gene expression and copy number.

Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth.

Human 21T breast epithelial cell lines mimic breast cancer progression in vivo and in vitro and show stage-specific gene expression patterns.

Role of the metastasis-promoting protein osteopontin in the tumour microenvironment.

Does tumour dormancy offer a therapeutic target?

The synthetic triterpenoid CDDO-Imidazolide suppresses experimental liver metastasis.

Gene signatures of breast cancer progression and metastasis.

Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis.

Pre- and post-translational regulation of osteopontin in cancer.

Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer.

In vivo single scan detection of both iron-labeled cells and breast cancer metastases in the mouse brain using balanced steady-state free precession imaging at 1.5 T.

In vivo characterization of changing blood-tumor barrier permeability in a mouse model of breast cancer metastasis: a complementary magnetic resonance imaging approach.

Osteopontin increases breast cancer cell sensitivity to specific signaling pathway inhibitors in preclinical models.

Neuropeptide Y stimulates proliferation and migration in the 4T1 breast cancer cell line.

β1-integrin: a potential therapeutic target in the battle against cancer recurrence.

An emerging role for the nuclear localization of maspin in the suppression of tumor progression and metastasis (1) (1) This article is part of Special Issue entitled Asilomar Chromatin and has undergone the Journal's usual peer review process.

Imaging the impact of chemically inducible proteins on cellular dynamics in vivo.

Co-expression of α9β1 integrin and VEGF-D confers lymphatic metastatic ability to a human breast cancer cell line MDA-MB-468LN.

Assessing cancer cell migration and metastatic growth in vivo in the chick embryo using fluorescence intravital imaging.

In Vivo Magnetic Resonance Imaging for Investigating the Development and Distribution of Experimental Brain Metastases due to Breast Cancer.

Brain metastases from breast cancer: lessons from experimental magnetic resonance imaging studies and clinical implications.

Hypoxia promotes tumor cell motility via RhoA and ROCK1 signaling pathways.

Assessment of osteopontin in early breast cancer: correlative study in a randomised clinical trial.

Radiation-induced lung injury after concurrent neoadjuvant chemoradiotherapy for locally advanced breast cancer.

A method to validate quantitative high-frequency power doppler ultrasound with fluorescence in vivo video microscopy.

Cyclin A2, a novel regulator of EMT.

BRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell proliferation, metabolism, and metastasis.

Tumor-α9β1 integrin-mediated signaling induces breast cancer growth and lymphatic metastasis via the recruitment of cancer-associated fibroblasts.

Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis.

Stage of breast cancer progression influences cellular response to activation of the WNT/planar cell polarity pathway.

An open letter to the FDA and other regulatory agencies: Preclinical drug development must consider the impact on metastasis.

CORRIGENDUM: Stage of Breast Cancer Progression Influences Cellular Response to Activation of the WNT/Planar Cell Polarity Pathway.