Rick Maizels

Full-length-enriched cDNA libraries from Echinococcus granulosus contain separate populations of oligo-capped and trans-spliced transcripts and a high level of predicted signal peptide sequences.

Molecular helminthology: an integrated approach.

Homologues of human macrophage migration inhibitory factor from a parasitic nematode. Gene cloning, protein activity, and crystal structure.

Abundant larval transcript-1 and -2 genes from Brugia malayi: diversity of genomic environments but conservation of 5' promoter sequences functional in Caenorhabditis elegans.

Immune regulation by helminth parasites: cellular and molecular mechanisms.

Regulation of allergy and autoimmunity in helminth infection.

Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus.

Signal sequence analysis of expressed sequence tags from the nematode Nippostrongylus brasiliensis and the evolution of secreted proteins in parasites.

Linked thioredoxin-glutathione systems in platyhelminths.

Resistance to helminth infection: the case for interleukin-5-dependent mechanisms.

Lymphatic filariasis and Brugia timori: prospects for elimination.

Helminth parasites--masters of regulation.

Selective maturation of dendritic cells by Nippostrongylus brasiliensis-secreted proteins drives Th2 immune responses.

Th2 induction by Nippostrongylus secreted antigens in mice deficient in B cells, eosinophils or MHC Class I-related receptors.

Comparison of IgG-ELISA and IgG4-ELISA for Toxocara serodiagnosis.

Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells.

Bm-CPI-2, a cystatin from Brugia malayi nematode parasites, differs from Caenorhabditis elegans cystatins in a specific site mediating inhibition of the antigen-processing enzyme AEP.

Heterologous expression of the filarial nematode alt gene products reveals their potential to inhibit immune function.

Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo.

Praziquantel treatment of individuals exposed to Schistosoma haematobium enhances serological recognition of defined parasite antigens.

Infections and allergy - helminths, hygiene and host immune regulation.

Regulatory T cells induced by parasites and the modulation of allergic responses.

Suppression of allergic airway inflammation by helminth-induced regulatory T cells.

A new C-type lectin similar to the human immunoreceptor DC-SIGN mediates symbiont acquisition by a marine nematode.

Molecular and cellular biology of helminth parasites IV.

F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection.

Immuno-epidemiology of human Schistosoma haematobium infection: preferential IgG3 antibody responsiveness to a recombinant antigen dependent on age and parasite burden.

IL-4R signaling is required to induce IL-10 for the establishment of T(h)2 dominance.

O-methylated glycans from Toxocara are specific targets for antibody binding in human and animal infections.

Regulation of the immune system in metazoan parasite infections.

Expansion and activation of CD4(+)CD25(+) regulatory T cells in Heligmosomoides polygyrus infection.

CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo.

Cytokine responses to Schistosoma haematobium in a Zimbabwean population: contrasting profiles for IFN-gamma, IL-4, IL-5 and IL-10 with age.

Alarming dendritic cells for Th2 induction.

Cystatins from filarial parasites: evolution, adaptation and function in the host-parasite relationship.

The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products.

Age-related and infection intensity-related shifts in antibody recognition of defined protein antigens in a schistosome-exposed population.

Four abundant novel transcript genes from Toxocara canis with unrelated coding sequences share untranslated region tracts implicated in the control of gene expression.

T-cell regulation in helminth parasite infections: implications for inflammatory diseases.

Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi.

Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection.

MIF homologues from a filarial nematode parasite synergize with IL-4 to induce alternative activation of host macrophages.

A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo.

How common is human toxocariasis? Towards standardizing our knowledge.

Generating EST libraries: trans-spliced cDNAs.

Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage.

Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity.

Parasite immunomodulation and polymorphisms of the immune system.

C-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis.

A family of diverse Kunitz inhibitors from Echinococcus granulosus potentially involved in host-parasite cross-talk.

Dynamics of CD11c(+) dendritic cell subsets in lymph nodes draining the site of intestinal nematode infection.

Regulation of pathogenesis and immunity in helminth infections.

Regulatory T cells in human geohelminth infection suppress immune responses to BCG and Plasmodium falciparum.

Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation.

CD11c depletion severely disrupts Th2 induction and development in vivo.

Developmental regulation and extracellular release of a VSG expression-site-associated gene product from Trypanosoma brucei bloodstream forms.

Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway.

Heligmosomoides polygyrus: one species still.

Regulatory and activated T cells in human Schistosoma haematobium infections.

Defeating sepsis by misleading MyD88.

Immunology. Eosinophils forestall obesity.

Schistosome infection intensity is inversely related to auto-reactive antibody levels.

Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103- dendritic cells.

Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor.

Diversity and dialogue in immunity to helminths.

Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo.

Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins.

Addendum: Defeating sepsis by misleading MyD88.

Immune modulation and modulators in Heligmosomoides polygyrus infection.

Heligmosomoides polygyrus elicits a dominant nonprotective antibody response directed against restricted glycan and peptide epitopes.

Wild immunology: converging on the real world.

Regulatory T cells in infection.

T cells in helminth infection: the regulators and the regulated.

Forum: Immunology: Allergy challenged.

Regulatory T cells in human lymphatic filariasis: stronger functional activity in microfilaremics.

Suppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus.

Cutting edge: in the absence of TGF-β signaling in T cells, fewer CD103+ regulatory T cells develop, but exuberant IFN-γ production renders mice more susceptible to helminth infection.

Prevention of birch pollen-related food allergy by mucosal treatment with multi-allergen-chimers in mice.

Susceptibility and immunity to helminth parasites.

Type 2 innate immunity in helminth infection is induced redundantly and acts autonomously following CD11c(+) cell depletion.

Antibodies and IL-3 support helminth-induced basophil expansion.

Helminth infections and host immune regulation.

Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus.

A transcriptomic analysis of Echinococcus granulosus larval stages: implications for parasite biology and host adaptation.

Immunomodulation by helminth parasites: defining mechanisms and mediators.

ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection.

Toxocara canis: molecular basis of immune recognition and evasion.

Gain of function in the immune system caused by a ryanodine receptor 1 mutation.

Oesophagostomum dentatum extract modulates T cell-dependent immune responses to bystander antigens and prevents the development of allergy in mice.

Into the wild: digging at immunology's evolutionary roots.

Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity.

Helminths and immunological tolerance.

IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1.

IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo.

Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection.

The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo.

Vaccination against helminth parasite infections.

Real-time PCR detection of the HhaI tandem DNA repeat in pre- and post-patent Brugia malayi Infections: a study in Indonesian transmigrants.

Inflammatory Bowel Disease.

Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensis.

Immunology. How helminths go viral.

MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus.

Commensal-pathogen interactions in the intestinal tract: lactobacilli promote infection with, and are promoted by, helminth parasites.

MHC-II: a mutual support system for ILCs and T cells?

Exosomes secreted by nematode parasites transfer small RNAs to mammalian cells and modulate innate immunity.

CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.

Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection.

Suppression of OVA-alum induced allergy by Heligmosomoides polygyrus products is MyD88-, TRIF-, regulatory T- and B cell-independent, but is associated with reduced innate lymphoid cell activation.

Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection.