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Manchester Collaborative Centre for Inflammation Research

1 ARTICLES PUBLISHED IN JoVE

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Immunology and Infection

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products
Chris J. C. Johnston 1, Elaine Robertson 1, Yvonne Harcus 1, John R. Grainger 2, Gillian Coakley 1, Danielle J. Smyth 1, Henry J. McSorley 1, Rick Maizels 1
1Institute of Immunology and Infection Research, University of Edinburgh, 2Manchester Collaborative Centre for Inflammation Research

Heligmosomoides polygyrus is a murine nematode with powerful immunomodulatory capabilities that closely resemble those of highly-prevalent human helminth infection. Here we describe a protocol for the long-term maintenance of the H. polygyrus lifecycle.

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