Lucy Shapiro

Genes directly controlled by CtrA, a master regulator of the Caulobacter cell cycle.

Dynamic localization of proteins and DNA during a bacterial cell cycle.

Control of chromosome replication in caulobacter crescentus.

A dynamically localized histidine kinase controls the asymmetric distribution of polar pili proteins.

DNA methylation affects the cell cycle transcription of the CtrA global regulator in Caulobacter.

A signal transduction protein cues proteolytic events critical to Caulobacter cell cycle progression.

Identification of a localization factor for the polar positioning of bacterial structural and regulatory proteins.

The CtrA response regulator essential for Caulobacter crescentus cell-cycle progression requires a bipartite degradation signal for temporally controlled proteolysis.

Generating and exploiting polarity in bacteria.

TmRNA is required for correct timing of DNA replication in Caulobacter crescentus.

Functions of the CckA histidine kinase in Caulobacter cell cycle control.

tmRNA in Caulobacter crescentus is cell cycle regulated by temporally controlled transcription and RNA degradation.

Temporal and spatial regulation in prokaryotic cell cycle progression and development.

Cell-cycle-regulated expression and subcellular localization of the Caulobacter crescentus SMC chromosome structural protein.

Polar localization of replicon origins in the multipartite genomes of Agrobacterium tumefaciens and Sinorhizobium meliloti.

Bacterial cell division spirals into control.

Fluorescence bleaching reveals asymmetric compartment formation prior to cell division in Caulobacter.

A lytic transglycosylase homologue, PleA, is required for the assembly of pili and the flagellum at the Caulobacter crescentus cell pole.

Identification of long intergenic repeat sequences associated with DNA methylation sites in Caulobacter crescentus and other alpha-proteobacteria.

A bacterial cell-cycle regulatory network operating in time and space.

Codon usage between genomes is constrained by genome-wide mutational processes.

Oscillating global regulators control the genetic circuit driving a bacterial cell cycle.

Recruitment of a cytoplasmic response regulator to the cell pole is linked to its cell cycle-regulated proteolysis.

An actin-like gene can determine cell polarity in bacteria.

Rapid and sequential movement of individual chromosomal loci to specific subcellular locations during bacterial DNA replication.

The topoisomerase IV ParC subunit colocalizes with the Caulobacter replisome and is required for polar localization of replication origins.

A genetic oscillator and the regulation of cell cycle progression in Caulobacter crescentus.

Spatial complexity of mechanisms controlling a bacterial cell cycle.

A membrane metalloprotease participates in the sequential degradation of a Caulobacter polarity determinant.

MreB actin-mediated segregation of a specific region of a bacterial chromosome.

An open letter to Elias Zerhouni.

The structure and function of the bacterial chromosome.

The choreographed dynamics of bacterial chromosomes.

Conserved modular design of an oxygen sensory/signaling network with species-specific output.

The bacterial nucleoid: a highly organized and dynamic structure.

Identification of borinic esters as inhibitors of bacterial cell growth and bacterial methyltransferases, CcrM and MenH.

DnaA coordinates replication initiation and cell cycle transcription in Caulobacter crescentus.

Two independent spiral structures control cell shape in Caulobacter.

Cytokinesis signals truncation of the PodJ polarity factor by a cell cycle-regulated protease.

DnaA couples DNA replication and the expression of two cell cycle master regulators.

The bifunctional FtsK protein mediates chromosome partitioning and cell division in Caulobacter.

A dynamically localized protease complex and a polar specificity factor control a cell cycle master regulator.

A phospho-signaling pathway controls the localization and activity of a protease complex critical for bacterial cell cycle progression.

Single molecules of the bacterial actin MreB undergo directed treadmilling motion in Caulobacter crescentus.

MipZ, a spatial regulator coordinating chromosome segregation with cell division in Caulobacter.

Chromosome organization and segregation in bacteria.

High-throughput identification of transcription start sites, conserved promoter motifs and predicted regulons.

The push and pull of the bacterial cytoskeleton.

An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site.

Spatial complexity and control of a bacterial cell cycle.

Caulobacter crescentus as a whole-cell uranium biosensor.

Cell cycle regulation in Caulobacter: location, location, location.

A DNA methylation ratchet governs progression through a bacterial cell cycle.

A comprehensive set of plasmids for vanillate- and xylose-inducible gene expression in Caulobacter crescentus.

Getting organized--how bacterial cells move proteins and DNA.

Systems biology of Caulobacter.

Small non-coding RNAs in Caulobacter crescentus.

Architecture and inherent robustness of a bacterial cell-cycle control system.

SpoT regulates DnaA stability and initiation of DNA replication in carbon-starved Caulobacter crescentus.

Super-resolution imaging in live Caulobacter crescentus cells using photoswitchable EYFP.

A polymeric protein anchors the chromosomal origin/ParB complex at a bacterial cell pole.

Caulobacter requires a dedicated mechanism to initiate chromosome segregation.

A bacterial control circuit integrates polar localization and proteolysis of key regulatory proteins with a phospho-signaling cascade.

Feedback control of DnaA-mediated replication initiation by replisome-associated HdaA protein in Caulobacter.

System-level design of bacterial cell cycle control.

Caulobacter PopZ forms a polar subdomain dictating sequential changes in pole composition and function.

High-throughput identification of protein localization dependency networks.

Bacterial chromosome organization and segregation.

Cell pole-specific activation of a critical bacterial cell cycle kinase.

DipM links peptidoglycan remodelling to outer membrane organization in Caulobacter.

Polar remodeling and histidine kinase activation, which is essential for Caulobacter cell cycle progression, are dependent on DNA replication initiation.

CrfA, a small noncoding RNA regulator of adaptation to carbon starvation in Caulobacter crescentus.

A spindle-like apparatus guides bacterial chromosome segregation.

The caulobacter Tol-Pal complex is essential for outer membrane integrity and the positioning of a polar localization factor.

Imaging-based identification of a critical regulator of FtsZ protofilament curvature in Caulobacter.

Superresolution imaging of targeted proteins in fixed and living cells using photoactivatable organic fluorophores.

Initiating bacterial mitosis: understanding the mechanism of ParA-mediated chromosome segregation.

An essential transcription factor, SciP, enhances robustness of Caulobacter cell cycle regulation.

Bacterial polarity.

The architecture and conservation pattern of whole-cell control circuitry.

Super-resolution imaging of the nucleoid-associated protein HU in Caulobacter crescentus.

Regulatory response to carbon starvation in Caulobacter crescentus.

Assembly of the Caulobacter cell division machine.

Mutations in the nucleotide binding pocket of MreB can alter cell curvature and polar morphology in Caulobacter.

Fifty years after Jacob and Monod: what are the unanswered questions in molecular biology?

The essential genome of a bacterium.

Exploring protein superstructures and dynamics in live bacterial cells using single-molecule and superresolution imaging.

An SMC ATPase mutant disrupts chromosome segregation in Caulobacter.

The three-dimensional architecture of a bacterial genome and its alteration by genetic perturbation.

Three-dimensional superresolution colocalization of intracellular protein superstructures and the cell surface in live Caulobacter crescentus.

Structure of the pilus assembly protein TadZ from Eubacterium rectale: implications for polar localization.

Three-dimensional super-resolution imaging of the midplane protein FtsZ in live Caulobacter crescentus cells using astigmatism.

Osmolality-dependent relocation of penicillin-binding protein PBP2 to the division site in Caulobacter crescentus.

Life in a three-dimensional grid.

Chromosome architecture is a key element of bacterial cellular organization.

Caulobacter chromosome in vivo configuration matches model predictions for a supercoiled polymer in a cell-like confinement.

Quantitative multicolor subdiffraction imaging of bacterial protein ultrastructures in three dimensions.

Retrospective. Francois Jacob (1920-2013).

Branched signal wiring of an essential bacterial cell-cycle phosphotransfer protein.

Oligomerization and higher-order assembly contribute to sub-cellular localization of a bacterial scaffold.

Global methylation state at base-pair resolution of the Caulobacter genome throughout the cell cycle.

The functions of DNA methylation by CcrM in Caulobacter crescentus: a global approach.

Bacterial scaffold directs pole-specific centromere segregation.

ClpXP and ClpAP proteolytic activity on divisome substrates is differentially regulated following the Caulobacter asymmetric cell division.

The coding and noncoding architecture of the Caulobacter crescentus genome.

Replication initiator DnaA binds at the Caulobacter centromere and enables chromosome segregation.

Cell fate regulation governed by a repurposed bacterial histidine kinase.

The global regulatory architecture of transcription during the Caulobacter cell cycle.