Carol Troy

Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases.

Caspases on the brain.

Divergence of the apoptotic pathways induced by 4-hydroxynonenal and amyloid beta-protein.

Balancing neuronal death.

Highly efficient small interfering RNA delivery to primary mammalian neurons induces MicroRNA-like effects before mRNA degradation.

Caspase function in neuronal death: delineation of the role of caspases in ischemia.

Cell cycle molecules define a pathway required for neuron death in development and disease.

Bim is elevated in Alzheimer's disease neurons and is required for beta-amyloid-induced neuronal apoptosis.

Mechanisms of neuronal death in disease: defining the models and the players.

Caspase-2: vestigial remnant or master regulator?

The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration.

Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways.

Cystatin C protects neuronal cells from amyloid-beta-induced toxicity.

Regulation of caspases in the nervous system implications for functions in health and disease.

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory.

Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke.

Neuronal caspase 2 activity and function requires RAIDD, but not PIDD.

Caspase inhibitors: prospective therapies for stroke.

Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection.

Caspase-2 is required for dendritic spine and behavioural alterations in J20 APP transgenic mice.

Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death.

Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling.

Axonally synthesized ATF4 transmits a neurodegenerative signal across brain regions.

Caspase-9 mediates photoreceptor death after blunt ocular trauma.

Caspases: therapeutic targets in neurologic disease.