Denis Martinvalet

Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis.

Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70.

Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.

Granzymes and cell death.

[A novel caspase-independent apoptotic pathway triggered by Granzyme A].

The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1.

miR-200 enhances mouse breast cancer cell colonization to form distant metastases.

Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis.

Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients.

Isolation of cytotoxic T cell and NK granules and purification of their effector proteins.

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.

Alterations in RNA processing during immune-mediated programmed cell death.

Natural autoantibodies to Fcγ receptors in intravenous immunoglobulins.

Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes.

Granzyme B-activated p53 interacts with Bcl-2 to promote cytotoxic lymphocyte-mediated apoptosis.