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Centre Médical Universitaire
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Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis.
Immunity Mar, 2005 | Pubmed ID: 15780992
Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70.
EMBO reports Apr, 2006 | Pubmed ID: 16440001
Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death.
Cell May, 2008 | Pubmed ID: 18485875
Granzymes and cell death.
Methods in enzymology , 2008 | Pubmed ID: 18662572
[A novel caspase-independent apoptotic pathway triggered by Granzyme A].
Médecine sciences : M/S Nov, 2008 | Pubmed ID: 19038084
The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1.
Blood Aug, 2009 | Pubmed ID: 19506301
miR-200 enhances mouse breast cancer cell colonization to form distant metastases.
PloS one , 2009 | Pubmed ID: 19787069
Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis.
Blood Feb, 2010 | Pubmed ID: 20038786
Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2010 | Pubmed ID: 20194725
Isolation of cytotoxic T cell and NK granules and purification of their effector proteins.
Current protocols in cell biology / editorial board, Juan S. Bonifacino ... [et al.] Jun, 2010 | Pubmed ID: 20521234
Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.
Nature immunology Aug, 2011 | Pubmed ID: 21685908
Alterations in RNA processing during immune-mediated programmed cell death.
Proceedings of the National Academy of Sciences of the United States of America May, 2012 | Pubmed ID: 22589304
Natural autoantibodies to Fcγ receptors in intravenous immunoglobulins.
Journal of clinical immunology Jul, 2014 | Pubmed ID: 24682714
Cytotoxic cells kill intracellular bacteria through granulysin-mediated delivery of granzymes.
Cell Jun, 2014 | Pubmed ID: 24906149
Granzyme B-activated p53 interacts with Bcl-2 to promote cytotoxic lymphocyte-mediated apoptosis.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2015 | Pubmed ID: 25404359
University of Geneva
Farokh Dotiwala1,
Isabelle Fellay2,
Luis Filgueira2,
Denis Martinvalet3,
Judy Lieberman1,
Michael Walch2
1Cellular and Molecular Medicine Program, Boston Children’s Hospital and Harvard Medical School,
2Department of Medicine, University of Fribourg,
3Centre Médical Universitaire, University of Geneva
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