Robert A. Screaton

Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation.

Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis.

cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.

Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2.

The glucocorticoid receptor controls hepatic dyslipidemia through Hes1.

Using kinomics to delineate signaling pathways: control of CRTC2/TORC2 by the AMPK family.

Transcriptional activation by MEIS1A in response to protein kinase A signaling requires the transducers of regulated CREB family of CREB co-activators.

A role for the CREB co-activator CRTC2 in the hypothalamic mechanisms linking glucose sensing with gene regulation.

Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice.

Depletion of intranuclear rodlets in mouse models of diabetes.

Regulation of the CREB coactivator TORC by the dual leucine zipper kinase at different levels.

Role of AMPK in pancreatic beta cell function.

Glucose metabolism and pancreatic defects in spinal muscular atrophy.

LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction.

CRTC2 is required for β-cell function and proliferation.

Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy.

ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics.

Essential role of TID1 in maintaining mitochondrial membrane potential homogeneity and mitochondrial DNA integrity.

Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.

SGK1: master and commander of the fate of helper T cells.

Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion.

High-content functional genomic screening to identify novel regulators of the PINK1-Parkin pathway.

LKB1 couples glucose metabolism to insulin secretion in mice.

Homozygous mutations in MFN2 cause multiple symmetric lipomatosis associated with neuropathy.

To Be(ta Cell) or Not to Be(ta cell): New Mouse Models for Studying Gene Function in the Pancreatic β-Cell.

Phenotypic characterization of MIP-CreERT1Lphi mice with transgene-driven islet expression of human growth hormone.