Sunnybrook Research Institute,
Department of Biochemistry
Robert A. Screaton has not added Biography.
If you are Robert A. Screaton and would like to personalize this page please email our Author Liaison for assistance.
Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation.
Neoplasia (New York, N.Y.) Mar-Apr, 2002 | Pubmed ID: 11896570
Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2003 | Pubmed ID: 12702765
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.
Genes & development Jul, 2003 | Pubmed ID: 12842910
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.
Cell Oct, 2004 | Pubmed ID: 15454081
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism.
Nature Oct, 2005 | Pubmed ID: 16148943
Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2008 | Pubmed ID: 18626018
The glucocorticoid receptor controls hepatic dyslipidemia through Hes1.
Cell metabolism Sep, 2008 | Pubmed ID: 18762022
Using kinomics to delineate signaling pathways: control of CRTC2/TORC2 by the AMPK family.
Cell cycle (Georgetown, Tex.) Dec, 2008 | Pubmed ID: 19098422
Transcriptional activation by MEIS1A in response to protein kinase A signaling requires the transducers of regulated CREB family of CREB co-activators.
The Journal of biological chemistry Jul, 2009 | Pubmed ID: 19473990
A role for the CREB co-activator CRTC2 in the hypothalamic mechanisms linking glucose sensing with gene regulation.
EMBO reports Oct, 2009 | Pubmed ID: 19713961
Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice.
Cell metabolism Oct, 2009 | Pubmed ID: 19808021
Depletion of intranuclear rodlets in mouse models of diabetes.
Endocrine pathology Dec, 2010 | Pubmed ID: 20922502
Regulation of the CREB coactivator TORC by the dual leucine zipper kinase at different levels.
Cellular signalling Feb, 2011 | Pubmed ID: 20940047
Role of AMPK in pancreatic beta cell function.
Molecular and cellular endocrinology Feb, 2013 | Pubmed ID: 22766107
Glucose metabolism and pancreatic defects in spinal muscular atrophy.
Annals of neurology Aug, 2012 | Pubmed ID: 22926856
LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction.
Human molecular genetics Mar, 2013 | Pubmed ID: 23187960
CRTC2 is required for β-cell function and proliferation.
Endocrinology Jul, 2013 | Pubmed ID: 23677932
Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy.
Autophagy Nov, 2013 | Pubmed ID: 24005319
ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics.
Science signaling , 2014 | Pubmed ID: 24473195
Essential role of TID1 in maintaining mitochondrial membrane potential homogeneity and mitochondrial DNA integrity.
Molecular and cellular biology Apr, 2014 | Pubmed ID: 24492964
Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.
Nature cell biology Mar, 2014 | Pubmed ID: 24561619
SGK1: master and commander of the fate of helper T cells.
Nature immunology May, 2014 | Pubmed ID: 24747705
Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion.
Molecular and cellular biology Jan, 2015 | Pubmed ID: 25332238
High-content functional genomic screening to identify novel regulators of the PINK1-Parkin pathway.
Methods in enzymology , 2014 | Pubmed ID: 25416349
LKB1 couples glucose metabolism to insulin secretion in mice.
Diabetologia Jul, 2015 | Pubmed ID: 25874445
Homozygous mutations in MFN2 cause multiple symmetric lipomatosis associated with neuropathy.
Human molecular genetics Jun, 2015 | Pubmed ID: 26085578
To Be(ta Cell) or Not to Be(ta cell): New Mouse Models for Studying Gene Function in the Pancreatic β-Cell.
Endocrinology Jul, 2015 | Pubmed ID: 26091426
Phenotypic characterization of MIP-CreERT1Lphi mice with transgene-driven islet expression of human growth hormone.
Diabetes Jul, 2015 | Pubmed ID: 26153246
JoVE 소개
Copyright © 2024 MyJoVE Corporation. 판권 소유