Luc Bertrand

The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase.

Signalling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes.

Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes.

Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis.

Insulin and ischemia stimulate glycolysis by acting on the same targets through different and opposing signaling pathways.

The stimulation of heart glycolysis by increased workload does not require AMP-activated protein kinase but a wortmannin-sensitive mechanism.

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia.

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis.

Activation of deoxycytidine kinase by protein kinase inhibitors and okadaic acid in leukemic cells.

6-Phosphofructo-2-kinase and fructose-2,6-bisphosphatase in Trypanosomatidae. Molecular characterization, database searches, modelling studies and evolutionary analysis.

Myocardial delivery of colloid nanoparticles using ultrasound-targeted microbubble destruction.

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity.

H11 kinase prevents myocardial infarction by preemptive preconditioning of the heart.

AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B.

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation.

[Regulation of energy metabolism by AMPK: a novel therapeutic approach for the treatment of metabolic and cardiovascular diseases].

Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.

Optical and EPR spectroscopic studies of demetallation of hemin by L-chain apoferritins.

Evaluation of the role of protein kinase Czeta in insulin-induced heart 6-phosphofructo-2-kinase activation.

Role of the alpha2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia.

IGF-I does not prevent myotube atrophy caused by proinflammatory cytokines despite activation of Akt/Foxo and GSK-3beta pathways and inhibition of atrogin-1 mRNA.

High-resolution X-ray structures of human apoferritin H-chain mutants correlated with their activity and metal-binding sites.

Dual cardiac contractile effects of the alpha2-AMPK deletion in low-flow ischemia and reperfusion.

Creatine enhances differentiation of myogenic C2C12 cells by activating both p38 and Akt/PKB pathways.

The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia.

Insulin signalling in the heart.

The conserved N-terminal domain of herpes simplex virus 1 UL24 protein is sufficient to induce the spatial redistribution of nucleolin.

AMPKalpha2 counteracts the development of cardiac hypertrophy induced by isoproterenol.

Comparison between adenoviral and retroviral vectors for the transduction of the thymidine kinase PET reporter gene in rat mesenchymal stem cells.

Myocardial injury induced by ultrasound-targeted microbubble destruction: evidence for the contribution of myocardial ischemia.

Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes.

AMPK: Lessons from transgenic and knockout animals.

Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity.

Conserved residues in the UL24 protein of herpes simplex virus 1 are important for dispersal of the nucleolar protein nucleolin.

Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation.

Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).

AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure.

Urocortin-induced cardiomyocytes hypertrophy is associated with regulation of the GSK-3β pathway.

Inhibition of the mTOR/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake.

The ribonucleotide reductase R1 subunits of herpes simplex virus 1 and 2 protect cells against poly(I · C)-induced apoptosis.

ER stress induces anabolic resistance in muscle cells through PKB-induced blockade of mTORC1.

Cardiac and neurological assessment of normothermia/warm blood cardioplegia vs hypothermia/cold crystalloid cardioplegia in pediatric cardiac surgery: insight from a prospective randomized trial.

NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1.

Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes.

Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia.

AMP-activated protein kinase in the control of cardiac metabolism and remodeling.

Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes.

Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart.

The Onecut transcription factor HNF-6 contributes to proper reorganization of Purkinje cells during postnatal cerebellum development.

Connection between cardiac vascular permeability, myocardial edema, and inflammation during sepsis: role of the α1AMP-activated protein kinase isoform.

Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells.

Enhanced expression of β3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase.

Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662.

Catalase expression in MCF-7 breast cancer cells is mainly controlled by PI3K/Akt/mTor signaling pathway.

Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases.

A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake.

Reduced scar maturation and contractility lead to exaggerated left ventricular dilation after myocardial infarction in mice lacking AMPKα1.

AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes.

Hypothermic continuous machine perfusion improves metabolic preservation and functional recovery in heart grafts.

Metformin: from mechanisms of action to therapies.

Dysregulation of Endoplasmic Reticulum Stress and Autophagic Responses by the Antiretroviral Drug Efavirenz.

Even is better than odd: one fat may conceal another.

Occludin controls HIV transcription in brain pericytes via regulation of SIRT-1 activation.

Hypothermic continuous machine perfusion enables preservation of energy charge and functional recovery of heart grafts in an ex vivo model of donation following circulatory death.

AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation.

Regulation of viral gene expression by the herpes simplex virus 1UL24 protein (HSV-1UL24 inhibits accumulation of viral transcripts).

Solving the Blood-Brain Barrier Challenge for the Effective Treatment of HIV Replication in the Central Nervous System.

O-GlcNAcylation, enemy or ally during cardiac hypertrophy development?

Fifteen days of 3,200 m simulated hypoxia marginally regulates markers for protein synthesis and degradation in human skeletal muscle.

Regulation of Carbohydrate Metabolism, Lipid Metabolism, and Protein Metabolism by AMPK.

AMPK in Cardiovascular Diseases.

Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription.

Antiretroviral Treatment with Efavirenz Disrupts the Blood-Brain Barrier Integrity and Increases Stroke Severity.

Extracellular vesicles of the blood-brain barrier: Role in the HIV-1 associated amyloid beta pathology.

Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart.