Department of Biochemistry and Molecular Biology,
Miller School of Medicine,
Department of Biochemistry and Molecular Biology, Miller School of Medicine
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The stimulation of glycolysis by hypoxia in activated monocytes is mediated by AMP-activated protein kinase and inducible 6-phosphofructo-2-kinase.
The Journal of biological chemistry Aug, 2002 | Pubmed ID: 12065600
Signalling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes.
European journal of biochemistry Aug, 2002 | Pubmed ID: 12153571
Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes.
European journal of biochemistry Aug, 2002 | Pubmed ID: 12153572
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis.
Current biology : CB Aug, 2002 | Pubmed ID: 12194824
Insulin and ischemia stimulate glycolysis by acting on the same targets through different and opposing signaling pathways.
Journal of molecular and cellular cardiology Sep, 2002 | Pubmed ID: 12392881
The stimulation of heart glycolysis by increased workload does not require AMP-activated protein kinase but a wortmannin-sensitive mechanism.
FEBS letters Nov, 2002 | Pubmed ID: 12417335
Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia.
The EMBO journal Sep, 2003 | Pubmed ID: 12970179
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis.
The Biochemical journal Aug, 2004 | Pubmed ID: 15170386
Activation of deoxycytidine kinase by protein kinase inhibitors and okadaic acid in leukemic cells.
Biochemical pharmacology Jul, 2004 | Pubmed ID: 15183121
6-Phosphofructo-2-kinase and fructose-2,6-bisphosphatase in Trypanosomatidae. Molecular characterization, database searches, modelling studies and evolutionary analysis.
The FEBS journal Jul, 2005 | Pubmed ID: 16008555
Myocardial delivery of colloid nanoparticles using ultrasound-targeted microbubble destruction.
European heart journal Jan, 2006 | Pubmed ID: 16166101
Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.
American journal of physiology. Endocrinology and metabolism May, 2006 | Pubmed ID: 16332922
Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity.
The Journal of biological chemistry Feb, 2006 | Pubmed ID: 16361699
H11 kinase prevents myocardial infarction by preemptive preconditioning of the heart.
Circulation research Feb, 2006 | Pubmed ID: 16373598
AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B.
American journal of physiology. Heart and circulatory physiology Jul, 2006 | Pubmed ID: 16489105
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation.
Diabetes Apr, 2006 | Pubmed ID: 16567505
[Regulation of energy metabolism by AMPK: a novel therapeutic approach for the treatment of metabolic and cardiovascular diseases].
Medecine sciences : M/S Apr, 2006 | Pubmed ID: 16597407
Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders.
The Journal of physiology Jul, 2006 | Pubmed ID: 16644802
Optical and EPR spectroscopic studies of demetallation of hemin by L-chain apoferritins.
Journal of inorganic biochemistry Aug, 2006 | Pubmed ID: 16781777
Evaluation of the role of protein kinase Czeta in insulin-induced heart 6-phosphofructo-2-kinase activation.
Cellular signalling Jan, 2007 | Pubmed ID: 16829026
Role of the alpha2-isoform of AMP-activated protein kinase in the metabolic response of the heart to no-flow ischemia.
American journal of physiology. Heart and circulatory physiology Dec, 2006 | Pubmed ID: 16877552
IGF-I does not prevent myotube atrophy caused by proinflammatory cytokines despite activation of Akt/Foxo and GSK-3beta pathways and inhibition of atrogin-1 mRNA.
American journal of physiology. Endocrinology and metabolism Jan, 2007 | Pubmed ID: 16926385
High-resolution X-ray structures of human apoferritin H-chain mutants correlated with their activity and metal-binding sites.
Journal of molecular biology Jan, 2007 | Pubmed ID: 17070541
Dual cardiac contractile effects of the alpha2-AMPK deletion in low-flow ischemia and reperfusion.
American journal of physiology. Heart and circulatory physiology Jun, 2007 | Pubmed ID: 17337600
Creatine enhances differentiation of myogenic C2C12 cells by activating both p38 and Akt/PKB pathways.
American journal of physiology. Cell physiology Oct, 2007 | Pubmed ID: 17652429
The relationship between p38 mitogen-activated protein kinase and AMP-activated protein kinase during myocardial ischemia.
Cardiovascular research Dec, 2007 | Pubmed ID: 17765884
Insulin signalling in the heart.
Cardiovascular research Jul, 2008 | Pubmed ID: 18390897
The conserved N-terminal domain of herpes simplex virus 1 UL24 protein is sufficient to induce the spatial redistribution of nucleolin.
The Journal of general virology May, 2008 | Pubmed ID: 18420791
AMPKalpha2 counteracts the development of cardiac hypertrophy induced by isoproterenol.
Biochemical and biophysical research communications Nov, 2008 | Pubmed ID: 18812163
Comparison between adenoviral and retroviral vectors for the transduction of the thymidine kinase PET reporter gene in rat mesenchymal stem cells.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine Nov, 2008 | Pubmed ID: 18984872
Myocardial injury induced by ultrasound-targeted microbubble destruction: evidence for the contribution of myocardial ischemia.
Ultrasound in medicine & biology Apr, 2009 | Pubmed ID: 19110365
Crucial role for LKB1 to AMPKalpha2 axis in the regulation of CD36-mediated long-chain fatty acid uptake into cardiomyocytes.
Biochimica et biophysica acta Mar, 2009 | Pubmed ID: 19159696
AMPK: Lessons from transgenic and knockout animals.
Frontiers in bioscience (Landmark edition) Jan, 2009 | Pubmed ID: 19273052
Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity.
Biochemical and biophysical research communications Aug, 2009 | Pubmed ID: 19486896
Conserved residues in the UL24 protein of herpes simplex virus 1 are important for dispersal of the nucleolar protein nucleolin.
Journal of virology Jan, 2010 | Pubmed ID: 19864385
Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation.
American journal of physiology. Endocrinology and metabolism Apr, 2010 | Pubmed ID: 20051528
Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).
The Biochemical journal Oct, 2010 | Pubmed ID: 20687898
AMPK activation, a preventive therapeutic target in the transition from cardiac injury to heart failure.
Cardiovascular research May, 2011 | Pubmed ID: 21285292
Urocortin-induced cardiomyocytes hypertrophy is associated with regulation of the GSK-3β pathway.
Heart and vessels Mar, 2012 | Pubmed ID: 21505854
Inhibition of the mTOR/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake.
American journal of physiology. Heart and circulatory physiology Aug, 2011 | Pubmed ID: 21602475
The ribonucleotide reductase R1 subunits of herpes simplex virus 1 and 2 protect cells against poly(I · C)-induced apoptosis.
Journal of virology Sep, 2011 | Pubmed ID: 21697465
ER stress induces anabolic resistance in muscle cells through PKB-induced blockade of mTORC1.
PloS one , 2011 | Pubmed ID: 21698202
Cardiac and neurological assessment of normothermia/warm blood cardioplegia vs hypothermia/cold crystalloid cardioplegia in pediatric cardiac surgery: insight from a prospective randomized trial.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery Dec, 2011 | Pubmed ID: 21752665
NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1.
Cardiovascular research Nov, 2011 | Pubmed ID: 21859816
Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes.
Peptides Feb, 2012 | Pubmed ID: 22244812
Role of the ductal transcription factors HNF6 and Sox9 in pancreatic acinar-to-ductal metaplasia.
Gut Dec, 2012 | Pubmed ID: 22271799
AMP-activated protein kinase in the control of cardiac metabolism and remodeling.
Current heart failure reports Sep, 2012 | Pubmed ID: 22767403
Overexpression of AMP-activated protein kinase or protein kinase D prevents lipid-induced insulin resistance in cardiomyocytes.
Journal of molecular and cellular cardiology Feb, 2013 | Pubmed ID: 23159540
Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart.
Biochimica et biophysica acta Jun, 2013 | Pubmed ID: 23466593
The Onecut transcription factor HNF-6 contributes to proper reorganization of Purkinje cells during postnatal cerebellum development.
Molecular and cellular neurosciences Sep, 2013 | Pubmed ID: 23669529
Connection between cardiac vascular permeability, myocardial edema, and inflammation during sepsis: role of the α1AMP-activated protein kinase isoform.
Critical care medicine Dec, 2013 | Pubmed ID: 23963133
Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells.
Cardiovascular research Jan, 2014 | Pubmed ID: 24104879
Enhanced expression of β3-adrenoceptors in cardiac myocytes attenuates neurohormone-induced hypertrophic remodeling through nitric oxide synthase.
Circulation Jan, 2014 | Pubmed ID: 24190960
Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662.
American journal of physiology. Endocrinology and metabolism Mar, 2014 | Pubmed ID: 24425763
Catalase expression in MCF-7 breast cancer cells is mainly controlled by PI3K/Akt/mTor signaling pathway.
Biochemical pharmacology May, 2014 | Pubmed ID: 24630930
Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases.
American journal of physiology. Gastrointestinal and liver physiology Jun, 2014 | Pubmed ID: 24742991
A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake.
American journal of physiology. Heart and circulatory physiology Jun, 2014 | Pubmed ID: 24748590
Reduced scar maturation and contractility lead to exaggerated left ventricular dilation after myocardial infarction in mice lacking AMPKα1.
Journal of molecular and cellular cardiology Sep, 2014 | Pubmed ID: 24805196
AMPK activation by glucagon-like peptide-1 prevents NADPH oxidase activation induced by hyperglycemia in adult cardiomyocytes.
American journal of physiology. Heart and circulatory physiology Oct, 2014 | Pubmed ID: 25128166
Hypothermic continuous machine perfusion improves metabolic preservation and functional recovery in heart grafts.
Transplant international : official journal of the European Society for Organ Transplantation Feb, 2015 | Pubmed ID: 25265884
Metformin: from mechanisms of action to therapies.
Cell metabolism Dec, 2014 | Pubmed ID: 25456737
Dysregulation of Endoplasmic Reticulum Stress and Autophagic Responses by the Antiretroviral Drug Efavirenz.
Molecular pharmacology Aug, 2015 | Pubmed ID: 25987489
Even is better than odd: one fat may conceal another.
American journal of physiology. Heart and circulatory physiology Oct, 2015 | Pubmed ID: 26297227
Occludin controls HIV transcription in brain pericytes via regulation of SIRT-1 activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Mar, 2016 | Pubmed ID: 26601824
Hypothermic continuous machine perfusion enables preservation of energy charge and functional recovery of heart grafts in an ex vivo model of donation following circulatory death.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery May, 2016 | Pubmed ID: 26604296
AMPK in cardiac fibrosis and repair: Actions beyond metabolic regulation.
Journal of molecular and cellular cardiology Feb, 2016 | Pubmed ID: 26772531
Regulation of viral gene expression by the herpes simplex virus 1UL24 protein (HSV-1UL24 inhibits accumulation of viral transcripts).
Virology Aug, 2016 | Pubmed ID: 27214229
Solving the Blood-Brain Barrier Challenge for the Effective Treatment of HIV Replication in the Central Nervous System.
Current pharmaceutical design , 2016 | Pubmed ID: 27464720
O-GlcNAcylation, enemy or ally during cardiac hypertrophy development?
Biochimica et biophysica acta Dec, 2016 | Pubmed ID: 27544701
Fifteen days of 3,200 m simulated hypoxia marginally regulates markers for protein synthesis and degradation in human skeletal muscle.
Hypoxia (Auckland, N.Z.) , 2016 | Pubmed ID: 27800505
Regulation of Carbohydrate Metabolism, Lipid Metabolism, and Protein Metabolism by AMPK.
EXS , 2016 | Pubmed ID: 27812975
AMPK in Cardiovascular Diseases.
EXS , 2016 | Pubmed ID: 27812981
Nuclear respiratory factor 1 and endurance exercise promote human telomere transcription.
Science advances Jul, 2016 | Pubmed ID: 27819056
Antiretroviral Treatment with Efavirenz Disrupts the Blood-Brain Barrier Integrity and Increases Stroke Severity.
Scientific reports Dec, 2016 | Pubmed ID: 28008980
Extracellular vesicles of the blood-brain barrier: Role in the HIV-1 associated amyloid beta pathology.
Molecular and cellular neurosciences Dec, 2016 | Pubmed ID: 28040512
Sodium-myoinositol cotransporter-1, SMIT1, mediates the production of reactive oxygen species induced by hyperglycemia in the heart.
Scientific reports Jan, 2017 | Pubmed ID: 28128227
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