Steven Nusinowitz

Identification of DES1 as a vitamin A isomerase in Müller glial cells of the retina.

Progressive photoreceptor degeneration, outer segment dysplasia, and rhodopsin mislocalization in mice with targeted disruption of the retinitis pigmentosa-1 (Rp1) gene.

Causes of cataract development in anesthetized mice.

Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.

Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3.

Mouse model of subretinal neovascularization with choroidal anastomosis.

Electroretinographic evidence for altered phototransduction gain and slowed recovery from photobleaches in albino mice with a MET450 variant in RPE65.

Standard full-field electroretinography in healthy preterm infants.

Isotretinoin treatment inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.

Surveillance of the eye and vision in a clinical trial of MART1-transformed dendritic cells for metastatic melanoma.

Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells.

Retinal degeneration 12 (rd12): a new, spontaneously arising mouse model for human Leber congenital amaurosis (LCA).

Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis.

Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases.

Mouse models of age-related macular degeneration.

Deficiency of SHP-1 protein-tyrosine phosphatase in "viable motheaten" mice results in retinal degeneration.

Disruption of the gene encoding the beta1-subunit of transducin in the Rd4/+ mouse.

Contrast sensitivity and color vision in HIV-infected individuals without infectious retinopathy.

Transgenic mice carrying the H258N mutation in the gene encoding the beta-subunit of phosphodiesterase-6 (PDE6B) provide a model for human congenital stationary night blindness.

Cone photoreceptor function loss-3, a novel mouse model of achromatopsia due to a mutation in Gnat2.

Longitudinal cohort study of patients with birdshot chorioretinopathy II: color vision at baseline.

Surveillance of the eye and vision in clinical trials of CP-675,206 for metastatic melanoma.

Somatic ablation of the Lrat gene in the mouse retinal pigment epithelium drastically reduces its retinoid storage.

Involvement of OA1, an intracellular GPCR, and G alpha i3, its binding protein, in melanosomal biogenesis and optic pathway formation.

Accelerated accumulation of lipofuscin pigments in the RPE of a mouse model for ABCA4-mediated retinal dystrophies following Vitamin A supplementation.

Non-invasive gene transfer by iontophoresis for therapy of an inherited retinal degeneration.

The role of interphotoreceptor retinoid-binding protein on the translocation of visual retinoids and function of cone photoreceptors.

Optic neuritis in different strains of mice by a recombinant HSV-1 expressing murine interleukin-2.

Differential expression and function of ABCG1 and ABCG4 during development and aging.

Test-retest reliability and inter-ocular symmetry of multi-focal electroretinography in Stargardt disease.

The mouse model of Down syndrome Ts65Dn presents visual deficits as assessed by pattern visual evoked potentials.

Dysfunction of heterotrimeric kinesin-2 in rod photoreceptor cells and the role of opsin mislocalization in rapid cell death.

Severe neurologic impairment in mice with targeted disruption of the electrogenic sodium bicarbonate cotransporter NBCe2 (Slc4a5 gene).

PTEN regulates retinal interneuron morphogenesis and synaptic layer formation.

Functional and morphological analysis of the subretinal injection of retinal pigment epithelium cells.

Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6.

Neuronal programmed cell death-1 ligand expression regulates retinal ganglion cell number in neonatal and adult mice.

Molecular diagnosis of putative Stargardt Disease probands by exome sequencing.

Intrinsically photosensitive retinal ganglion cells are the primary but not exclusive circuit for light aversion.

Comparative regional pupillography as a noninvasive biosensor screening method for diabetic retinopathy.

Functional burden of strabismus: decreased binocular summation and binocular inhibition.

CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Müller glial cells.

Whole exome sequencing detects homozygosity for ABCA4 p.Arg602Trp missense mutation in a pediatric patient with rapidly progressive retinal dystrophy.

Endophenotypes for Age-Related Macular Degeneration: Extending Our Reach into the Preclinical Stages of Disease.

Light aversion and corneal mechanical sensitivity are altered by intrinscally photosensitive retinal ganglion cells in a mouse model of corneal surface damage.

Biocompatibility of a Synthetic Biopolymer for the Treatment of Rhegmatogenous Retinal Detachment.

Peripheral Sensory Neurons Expressing Melanopsin Respond to Light.