Christopher M. Olsen

Intravenous ethanol/cocaine self-administration initiates high intake of intravenous ethanol alone.

Chronic D1 agonist and ethanol coadministration facilitate ethanol-mediated behaviors.

Serotonergic neurotoxic metabolites of ecstasy identified in rat brain.

Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell.

Prefrontal cortex D1 modulation of the reinforcing properties of cocaine.

Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration.

A method for single-session cocaine self-administration in the mouse.

Experience-dependent effects of cocaine self-administration/conditioning on prefrontal and accumbens dopamine responses.

Microarray analysis reveals distinctive signaling between the bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum.

Operant sensation seeking engages similar neural substrates to operant drug seeking in C57 mice.

Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5).

天然奖励、 神经可塑性和非药物成瘾。

(3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addiction.

Noncovalent PEGylation by polyanion complexation as a means to stabilize keratinocyte growth factor-2 (KGF-2).

Stimulus dynamics increase the self-administration of compound visual and auditory stimuli.

Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu(5) ): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound.