Guofu Zhong

Facile domino access to chiral bicyclo[3.2.1]octanes and discovery of a new catalytic activation mode.

A highly enantioselective amino acid-catalyzed route to functionalized alpha-amino acids.

A facile and rapid route to highly enantiopure 1,2-diols by novel catalytic asymmetric alpha-aminoxylation of aldehydes.

Tandem aminoxylation-allylation reactions: a rapid, asymmetric conversion of aldehydes to mono-substituted 1,2-diols.

Enantioselective synthesis of allylic alcohols by the sequential aminoxylation-olefination reactions of aldehydes under ambient conditions.

The origin of enantioselectivity in aldolase antibodies: crystal structure, site-directed mutagenesis, and computational analysis.

Organocatalytic asymmetric tandem Michael-Henry reactions: a highly stereoselective synthesis of multifunctionalized cyclohexanes with two quaternary stereocenters.

Control of four stereocenters in an organocatalytic domino double Michael reaction: efficient synthesis of multisubstituted cyclopentanes.

A highly diastereo- and enantioselective synthesis of multisubstituted cyclopentanes with four chiral carbons by the organocatalytic domino Michael-Henry reaction.

A highly stereoselective organocatalytic tandem aminoxylation/aza-Michael reaction for the synthesis of tetrahydro-1,2-oxazines.

Organocatalytic asymmetric alpha-aminoxylation/aza-Michael reactions for the synthesis of functionalized tetrahydro-1,2-oxazines.

Unusual domino michael/aldol condensation reactions employing oximes as N-selective nucleophiles: synthesis of N-hydroxypyrroles.

An unexpected N-heterocyclic carbene-catalyzed annulation of enals and nitroso compounds.

Chiral Brønsted acid-catalyzed enantioselective alpha-hydroxylation of beta-dicarbonyl compounds.

Recyclable organocatalysis: highly enantioselective Michael addition of 1,3-diaryl-1,3-propanedione to nitroolefins.

Rational design of organocatalyst: highly stereoselective Michael addition of cyclic ketones to nitroolefins.

L-prolinol as a highly enantioselective catalyst for Michael addition of cyclohexanone to nitroolefins.

Highly efficient asymmetric trans-selective aziridination of diazoacetamides and N-Boc-imines catalyzed by chiral Brønsted acids.

Highly stereoselective one-pot synthesis of bicyclic isoxazolidines with five stereogenic centers by an organocatalytic process.

Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis.

Water--more than just a green solvent: a stereoselective one-pot access to all-chiral tetrahydronaphthalenes in aqueous media.

Diastereoselective HOTf-catalyzed three-component one-pot 1,3-dipolar cycloaddition of alpha-diazo ester, nitrosobenzene and electron-deficient alkene.

Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes.

Chiral Brønsted acid catalyzed enantioselective α-aminoxylation of enecarbamates.

Highly stereoselective synthesis of indanes with four stereogenic centers via sequential Michael reaction and [3+2] cycloaddition.

Catalytic asymmetric formal [4 + 1] annulation leading to optically active cis-isoxazoline N-oxides.

Core structure-based design of organocatalytic [3+2]-cycloaddition reactions: highly efficient and stereocontrolled syntheses of 3,3'-pyrrolidonyl spirooxindoles.

N-heterocyclic carbene (NHC)-catalyzed highly diastereo- and enantioselective oxo-Diels-Alder reactions for synthesis of fused pyrano[2,3-b]indoles.

[4+2] annulation of vinyl ketones initiated by a phosphine-catalyzed aza-Rauhut-Currier reaction: a practical access to densely functionalized tetrahydropyridines.

Catalytic asymmetric [4+2] annulation initiated by an aza-Rauhut-Currier reaction: facile entry to highly functionalized tetrahydropyridines.

C-C bond formation via copper-catalyzed conjugate addition reactions to enones in water at room temperature.

Asymmetric NHC-catalyzed aza-Diels-Alder reactions: highly enantioselective route to α-amino acid derivatives and DFT calculations.

Cooperative catalysis of N-heterocyclic carbene and Brønsted acid for a highly enantioselective route to unprotected spiro-indoline-pyrans.

Triflic Acid catalyzed formal [3 + 2] cycloaddition of donor-acceptor oxiranes and nitriles: a facile access to 3-oxazolines.

Rapid access to spirocylic oxindoles: application of asymmetric N-heterocyclic carbene-catalyzed [3 + 3] cycloaddition of imines to oxindole-derived enals.

N-Heterocyclic Carbene-Catalyzed Activation of Esters of N-Hydroxyphthalimide: A Highly Enantioselective Route to Chiral Dihydropyridinones Bearing an All Carbon Quaternary Stereogenic Center.

Enantioselective Construction of Spirocyclic Oxindole Derivatives with Multiple Stereocenters via an Organocatalytic Michael/Aldol/Hemiacetalization Cascade Reaction.

N-Heterocyclic Carbene/Lewis Acid Catalyzed Enantioselective Aerobic Annulation of α,β-Unsaturated Aldehydes with 1,3-Dicarbonyl Compounds.

Olefination of Electron-Deficient Alkenes with Allyl Acetate: Stereo- and Regioselective Access to (2Z,4E)-Dienamides.

A direct cross-coupling reaction of electron-deficient alkenes using an oxidizing directing group.

Weinreb amide directed cross-coupling reaction between electron-deficient alkenes catalyzed by a rhodium catalyst.

Enantioselective Dearomatization of Naphthol Derivatives with Allylic Alcohols by Cooperative Iridium and Brønsted Acid Catalysis.

Synthesis of Cyano-Containing Phenanthridine Derivatives via Catalyst-, Base-, and Oxidant-Free Direct Cyanoalkylarylation of Isocyanides.

Compatibility of Tanshinone IIA and Astragaloside IV in attenuating hypoxia-induced cardiomyocytes injury.

Copper-Catalyzed Oxidative Cyclization of 2-Amino-azaarenes with Lignin Models: Synthesis of 3-Phenoxy Imidazo Heterocycles.

Amide Directed Cross-Coupling between Alkenes and Alkynes: A Regio- and Stereoselective Approach to Substituted (2Z,4Z)-Dienamides.