Preclinical Research Department
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Genetic evidence for a novel thymidylate synthase in the halophilic archaeon Halobacterium salinarum and in Campylobacter jejuni.
FEMS microbiology letters Oct, 2002 | Pubmed ID: 12423760
FolM, a new chromosomally encoded dihydrofolate reductase in Escherichia coli.
Journal of bacteriology Dec, 2003 | Pubmed ID: 14617668
An alternative pathway for reduced folate biosynthesis in bacteria and halophilic archaea.
Molecular microbiology Dec, 2004 | Pubmed ID: 15554970
Microbial growth inhibition by alternating electric fields.
Antimicrobial agents and chemotherapy Oct, 2008 | Pubmed ID: 18663026
Alternating electric fields (TTFields) inhibit metastatic spread of solid tumors to the lungs.
Clinical & experimental metastasis , 2009 | Pubmed ID: 19387848
Microbial growth inhibition by alternating electric fields in mice with Pseudomonas aeruginosa lung infection.
Antimicrobial agents and chemotherapy Aug, 2010 | Pubmed ID: 20547811
Essential role of the CBD1-CBD2 linker in slow dissociation of Ca2+ from the regulatory two-domain tandem of NCX1.
The Journal of biological chemistry Sep, 2010 | Pubmed ID: 20587421
Proton-sensing Ca2+ binding domains regulate the cardiac Na+/Ca2+ exchanger.
The Journal of biological chemistry Aug, 2011 | Pubmed ID: 21680748
Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants.
Cell calcium Jun, 2012 | Pubmed ID: 22571864
A common Ca2+-driven interdomain module governs eukaryotic NCX regulation.
PloS one , 2012 | Pubmed ID: 22768191
KCNQ1 channels do not undergo concerted but sequential gating transitions in both the absence and the presence of KCNE1 protein.
The Journal of biological chemistry Oct, 2012 | Pubmed ID: 22908235
G503 is obligatory for coupling of regulatory domains in NCX proteins.
Biochemistry Sep, 2012 | Pubmed ID: 22924554
Molecular determinants of allosteric regulation in NCX proteins.
Advances in experimental medicine and biology , 2013 | Pubmed ID: 23224868
Population shift underlies Ca2+-induced regulatory transitions in the sodium-calcium exchanger (NCX).
The Journal of biological chemistry Aug, 2013 | Pubmed ID: 23798674
The C2B domain is the primary Ca2+ sensor in DOC2B: a structural and functional analysis.
Journal of molecular biology Nov, 2013 | Pubmed ID: 23994332
Mitotic disruption and reduced clonogenicity of pancreatic cancer cells in vitro and in vivo by tumor treating fields.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Jan-Feb, 2014 | Pubmed ID: 24555979
Alternating electric fields (tumor-treating fields therapy) can improve chemotherapy treatment efficacy in non-small cell lung cancer both in vitro and in vivo.
Seminars in oncology Oct, 2014 | Pubmed ID: 25213867
Functional asymmetry of bidirectional Ca2+-movements in an archaeal sodium-calcium exchanger (NCX_Mj).
Cell calcium Oct, 2014 | Pubmed ID: 25218934
Structure-dynamic determinants governing a mode of regulatory response and propagation of allosteric signal in splice variants of Na+/Ca2+ exchange (NCX) proteins.
The Biochemical journal Feb, 2015 | Pubmed ID: 25387769
Sodium recognition by the Na+/Ca2+ exchanger in the outward-facing conformation.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2014 | Pubmed ID: 25468964
Structure-dynamic basis of splicing-dependent regulation in tissue-specific variants of the sodium-calcium exchanger.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Mar, 2016 | Pubmed ID: 26644350
Mitotic Spindle Disruption by Alternating Electric Fields Leads to Improper Chromosome Segregation and Mitotic Catastrophe in Cancer Cells.
Scientific reports Dec, 2015 | Pubmed ID: 26658786
Modeling Tumor Treating Fields (TTFields) application in single cells during metaphase and telophase.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference , 2015 | Pubmed ID: 26737877
Asymmetric Preorganization of Inverted Pair Residues in the Sodium-Calcium Exchanger.
Scientific reports Feb, 2016 | Pubmed ID: 26876271
Structural Features of Ion Transport and Allosteric Regulation in Sodium-Calcium Exchanger (NCX) Proteins.
Frontiers in physiology , 2016 | Pubmed ID: 26903880
Kinetic and equilibrium properties of regulatory Ca(2+)-binding domains in sodium-calcium exchangers 2 and 3.
Cell calcium 04, 2016 | Pubmed ID: 26924806
Structure-Based Engineering of Lithium-Transport Capacity in an Archaeal Sodium-Calcium Exchanger.
Biochemistry Mar, 2016 | Pubmed ID: 26958982
Alternating electric fields (TTFields) in combination with paclitaxel are therapeutically effective against ovarian cancer cells in vitro and in vivo.
International journal of cancer Dec, 2016 | Pubmed ID: 27561100
Structure-Functional Basis of Ion Transport in Sodium-Calcium Exchanger (NCX) Proteins.
International journal of molecular sciences Nov, 2016 | Pubmed ID: 27879668
Purification and characterization of human dehydrodolychil diphosphate synthase (DHDDS) overexpressed in E. coli.
Protein expression and purification Apr, 2017 | Pubmed ID: 28167250
Structure-based dynamic arrays in regulatory domains of sodium-calcium exchanger (NCX) isoforms.
Scientific reports Apr, 2017 | Pubmed ID: 28428550
Strabismus and mental disorders among Israeli adolescents.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus Apr, 2017 | Pubmed ID: 28433442
Dynamic distinctions in the Na(+)/Ca(2+) exchanger adopting the inward- and outward-facing conformational states.
The Journal of biological chemistry Jul, 2017 | Pubmed ID: 28572509
Ilan Edri*,1,
Michal Goldenberg*,1,
Michal Lisnyansky2,
Roi Strulovich2,
Hadas Newman1,3,
Anat Loewenstein1,3,
Daniel Khananshvili2,
Moshe Giladi2,4,
Yoni Haitin2
1Sackler Faculty of Medicine, Tel Aviv University,
2Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University,
3Department of Ophthalmology, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University,
4Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University
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