Grant A. Ramm

The role of hepatic stellate cells and transforming growth factor-beta(1) in cystic fibrosis liver disease.

Aldehydic products of lipid peroxidation do not directly activate rat hepatic stellate cells.

Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

Evidence for a sub-morphological inflammatory process in the liver in haemochromatosis.

Identification and characterization of the hepatic stellate cell transferrin receptor.

Effect of protein kinase C activation and inhibition on rat hepatic stellate cell activation.

Quantitative analysis of the expression of ACAT genes in human tissues by real-time PCR.

Signals for Hepatic Figrogenesis in Pediatric Cholestatic Liver Disease: Review and Hypothesis.

Endogenous ursodeoxycholic acid and cholic acid in liver disease due to cystic fibrosis.

Serum markers of hepatic fibrogenesis in cystic fibrosis liver disease.

Hemojuvelin (HJV)-associated hemochromatosis: analysis of HJV and HFE mutations and iron overload in three families.

Is HFE involved in increased hepcidin expression and hypoferremia in inflammation and anemia of chronic disease?

Repair after cholestatic liver injury correlates with neutrophil infiltration and matrix metalloproteinase 8 activity.

Lymphotoxin-beta production following bile duct ligation: possible role for Kupffer cells.

Hepatotoxicity of iron overload: mechanisms of iron-induced hepatic fibrogenesis.

Outcome after portoenterostomy in biliary atresia: pivotal role of degree of liver fibrosis and intensity of stellate cell activation.

Screening for hemochromatosis in asymptomatic subjects with or without a family history.

A contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis.

A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis.

The clinical relevance of compound heterozygosity for the C282Y and H63D substitutions in hemochromatosis.

Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice.

A novel mutation in ferroportin implicated in iron overload.

Role of iron in hepatic fibrosis: one piece in the puzzle.

Effect of phorbol ester and platelet-derived growth factor on protein kinase C in rat hepatic stellate cells.

The function of serotonin within the liver.

Environmental and genetic modifiers of the progression to fibrosis and cirrhosis in hemochromatosis.

Hepatic macrophages promote the neutrophil-dependent resolution of fibrosis in repairing cholestatic rat livers.

Hereditary hemochromatosis in the post-HFE era.

Assessment of hepatic steatosis: comparison of quantitative and semiquantitative methods in 108 liver biopsies.

How much iron is too much?

Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury.

Fibrogenesis in pediatric cholestatic liver disease: role of taurocholate and hepatocyte-derived monocyte chemotaxis protein-1 in hepatic stellate cell recruitment.

Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis.

Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells.

Identification of ferritin receptors: their role in iron homeostasis, hepatic injury, and inflammation.

Chemokine (C-C motif) receptors in fibrogenesis and hepatic regeneration following acute and chronic liver disease.

Neutrophil depletion blocks early collagen degradation in repairing cholestatic rat livers.

Temporal expression of chemokines dictates the hepatic inflammatory infiltrate in a murine model of schistosomiasis.

Co-ordinated gene expression in the liver and spleen during Schistosoma japonicum infection regulates cell migration.

Iron homeostasis, hepatocellular injury, and fibrogenesis in hemochromatosis: the role of inflammation in a noninflammatory liver disease.

Importance of hepatic fibrosis in cystic fibrosis and the predictive value of liver biopsy.

High parasite burdens cause liver damage in mice following Plasmodium berghei ANKA infection independently of CD8(+) T cell-mediated immune pathology.

Cystic fibrosis-cirrhosis, portal hypertension, and liver biopsy: Reply.

Paediatric cholestatic liver disease: Diagnosis, assessment of disease progression and mechanisms of fibrogenesis.

Differential expression of chemokine and matrix re-modelling genes is associated with contrasting schistosome-induced hepatopathology in murine models.

Anti-chemokine therapy for the treatment of hepatic fibrosis: an attractive approach.

Possible role of WT1 in a human fetus with evolving bronchial atresia, pulmonary malformation and renal agenesis.

Transcriptional basis for hepatic fibrosis in cystic fibrosis-associated liver disease.

Abnormal WT1 expression in human fetuses with bilateral renal agenesis and cardiac malformations.

Clinical cofactors and hepatic fibrosis in hereditary hemochromatosis: the role of diabetes mellitus.

A membrane vesicle-based dual vaccine against melanoma and Lewis lung carcinoma.

Hepatic iron deposition does not predict extrahepatic iron loading in mouse models of hereditary hemochromatosis.

Role of resident liver cells in the pathogenesis of schistosomiasis.

Spatial and temporal transcriptomics of Schistosoma japonicum-induced hepatic granuloma formation reveals novel roles for neutrophils.

Schistosomajaponicum Eggs Induce a Proinflammatory, Anti-Fibrogenic Phenotype in Hepatic Stellate Cells.

Iron and hepatic carcinogenesis.

Ductular reaction in hereditary hemochromatosis: the link between hepatocyte senescence and fibrosis progression.

Role of TWEAK in coregulating liver progenitor cell and fibrogenic responses.

Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis.

TWEAK and LTβ Signaling during Chronic Liver Disease.

Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation.

Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload.

Circulating microRNAs as noninvasive diagnostic biomarkers of liver disease in children with cystic fibrosis.

Reduced mortality due to phlebotomy in moderately iron-loaded HFE haemochromatosis? The need for clinical trials.

Reply: To PMID 25605615.

Type 2 diabetes mellitus: limitations of conventional therapies and intervention with nucleic acid-based therapeutics.

An ex vivo model for studying hepatic schistosomiasis and the effect of released protein from dying eggs.

Case Report: Fetal Bilateral Diaphragmatic Agenesis, Ectopic Liver and Abnormal Pancreas.

Transcriptional profiling of chronic clinical hepatic schistosomiasis japonica indicates reduced metabolism and immune responses.

Aspartate aminotransferase to platelet ratio and fibrosis-4 as biomarkers in biopsy-validated pediatric cystic fibrosis liver disease.

The development of hepatic stellate cells in normal and abnormal human fetuses - an immunohistochemical study.

Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron).

Reply.

The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis.

Characterising granuloma regression and liver recovery in a murine model of schistosomiasis japonica.

Reply.

Value of the 8-oxodG/dG ratio in chronic liver inflammation of patients with hepatocellular carcinoma.

Mechanism of pancreatic and liver malformations in human fetuses with short-rib polydactyly syndrome.

Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury.

Transient liver elastography in unsedated control children: Impact of age and intercurrent illness.

Caveolin-1 Function in Liver Physiology and Disease.

Function and Regulation of MicroRNAs and Their Potential as Biomarkers in Paediatric Liver Disease.

Diagnosing schistosomiasis-induced liver morbidity: implications for global control.

GNPAT p.D519G is independently associated with markedly increased iron stores in HFE p.C282Y homozygotes.

Reply.

Serum ferritin concentration predicts hepatic fibrosis better than hepatic iron concentration in human HFE-Haemochromatosis.

Filling the Gap on Caveolin-1 in Liver Carcinogenesis.

Extracellular vesicles for personalized therapy decision support in advanced metastatic cancers and its potential impact for prostate cancer.

Taurocholate induces biliary differentiation of liver progenitor cells causing hepatic stellate cell chemotaxis in the Ductular Reaction: Role in pediatric cystic fibrosis liver disease.