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Murine Precision-Cut Liver Slices as an Ex Vivo Model of Liver Biology

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12:36 min

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March 14th, 2020

DOI :

10.3791/60992-v

March 14th, 2020

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14,986 Views

Michael A. Pearen*¹, Hong Kiat Lim*¹, Francis D. Gratte²^,³, Manuel A. Fernandez-Rojo¹^,⁴^,⁵, Sujeevi K. Nawaratna⁶, Geoffrey N. Gobert⁷, John K. Olynyk⁸^,⁹, Janina E. E. Tirnitz-Parker²^,¹⁰, Grant A. Ramm¹^,⁴

¹Hepatic Fibrosis Group, QIMR Berghofer Medical Research Institute, ²School of Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, ³School of Veterinary and Life Sciences, Murdoch University, ⁴School of Medicine, The University of Queensland, ⁵Madrid Institute for Advanced Studies (IMDEA) in Food, CEI UAM+CSIC, ⁶School of Medicine, Griffith University, ⁷School of Biological Sciences, Queen's University Belfast, ⁸Department of Gastroenterology & Hepatology, Fiona Stanley and Fremantle Hospital Group, ⁹School of Medical and Health Sciences, Edith Cowan University, ¹⁰Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, University of Western Australia

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Precision cut Liver Slices

Cholestatic Liver Injury

Hepatic Fibrogenesis

Krebs Henseleit Buffer

Peltier Thermoelectric Cooler

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