James R. Woodgett

DREAM is a critical transcriptional repressor for pain modulation.

The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease.

Role of glycogen synthase kinase-3 in cancer: regulation by Wnts and other signaling pathways.

Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.

CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.

A molecular compendium of genes expressed in multiple myeloma.

Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC.

Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival.

Open heart surgery of PI-3 kinase signaling.

GSK-3: tricks of the trade for a multi-tasking kinase.

JNK1 activity lowers the cellular production of H2O2 and modulates the growth arrest response to scavenging of H2O2 by catalase.

Unravelling the activation mechanisms of protein kinase B/Akt.

Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade.

Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium.

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.

Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation.

Recent advances in the protein kinase B signaling pathway.

CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome.

Problems with co-funding in Canada.

Differential gene expression profile reveals deregulation of pregnancy specific beta1 glycoprotein 9 early during colorectal carcinogenesis.

Chronic activation of protein kinase Bbeta/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: events associated with tumorigenesis.

GSK3: an in-Toll-erant protein kinase?

Modulating autoimmunity: pick your PI3 kinase.

NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo.

Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis.

Serum and glucocorticoid-regulated protein kinases: variations on a theme.

IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.

Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3.

Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration.

Glycogen synthase kinase-3--an overview of an over-achieving protein kinase.

Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth.

Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium.

CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Ctheta, c-Rel, and protein kinase B.

Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines.

Systematic discovery of in vivo phosphorylation networks.

Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions.

Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3.

GSK-3beta controls osteogenesis through regulating Runx2 activity.

Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism.

Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas.

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.

Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide.

Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts.

Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor?

Glycogen synthase kinase-3beta heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results.

Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes.

Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action.

Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes.

GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism.

Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation.

Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development.

Exploring pluripotency with chemical genetics.

IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain.

Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression.

GSK-3 is a master regulator of neural progenitor homeostasis.

Abnormalities in brain structure and behavior in GSK-3alpha mutant mice.

Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo.

When pathways collide: collaboration and connivance among signalling proteins in development.

Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.

Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility.

Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival.

Tissue-specific analysis of glycogen synthase kinase-3α (GSK-3α) in glucose metabolism: effect of strain variation.

Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling?

Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation.

Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice.

Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation.