Samuel Lunenfeld Research Institute
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DREAM is a critical transcriptional repressor for pain modulation.
Cell Jan, 2002 | Pubmed ID: 11792319
The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease.
Acta neuropathologica Feb, 2002 | Pubmed ID: 11810173
Role of glycogen synthase kinase-3 in cancer: regulation by Wnts and other signaling pathways.
Advances in cancer research , 2002 | Pubmed ID: 11883528
Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway.
Molecular and cellular biology Apr, 2002 | Pubmed ID: 11884598
CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.
The Journal of experimental medicine Aug, 2002 | Pubmed ID: 12163562
Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.
Molecular and cellular biology Sep, 2002 | Pubmed ID: 12167717
A molecular compendium of genes expressed in multiple myeloma.
Blood Sep, 2002 | Pubmed ID: 12200383
Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC.
Cellular signalling Jan, 2003 | Pubmed ID: 12401518
Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival.
The Journal of biological chemistry Feb, 2003 | Pubmed ID: 12458207
Open heart surgery of PI-3 kinase signaling.
Cell cycle (Georgetown, Tex.) Nov-Dec, 2002 | Pubmed ID: 12548014
GSK-3: tricks of the trade for a multi-tasking kinase.
Journal of cell science Apr, 2003 | Pubmed ID: 12615961
JNK1 activity lowers the cellular production of H2O2 and modulates the growth arrest response to scavenging of H2O2 by catalase.
Experimental cell research Apr, 2003 | Pubmed ID: 12681294
Unravelling the activation mechanisms of protein kinase B/Akt.
FEBS letters Jul, 2003 | Pubmed ID: 12829245
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2004 | Pubmed ID: 15044694
Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2004 | Pubmed ID: 15282284
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
Current biology : CB Aug, 2004 | Pubmed ID: 15324660
Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.
The Journal of biological chemistry Dec, 2004 | Pubmed ID: 15466414
Phosphoinositide-dependent phosphorylation of PDK1 regulates nuclear translocation.
Molecular and cellular biology Mar, 2005 | Pubmed ID: 15743829
Recent advances in the protein kinase B signaling pathway.
Current opinion in cell biology Apr, 2005 | Pubmed ID: 15780591
CpG Island microarray probe sequences derived from a physical library are representative of CpG Islands annotated on the human genome.
Nucleic acids research , 2005 | Pubmed ID: 15911630
Problems with co-funding in Canada.
Science (New York, N.Y.) Jun, 2005 | Pubmed ID: 15976286
Differential gene expression profile reveals deregulation of pregnancy specific beta1 glycoprotein 9 early during colorectal carcinogenesis.
BMC cancer , 2005 | Pubmed ID: 15982419
Chronic activation of protein kinase Bbeta/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: events associated with tumorigenesis.
Oncogene Aug, 2005 | Pubmed ID: 16007218
GSK3: an in-Toll-erant protein kinase?
Nature immunology Aug, 2005 | Pubmed ID: 16034428
Modulating autoimmunity: pick your PI3 kinase.
Nature medicine Sep, 2005 | Pubmed ID: 16145571
NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2005 | Pubmed ID: 16148125
Expression of Wnt-signaling pathway proteins in intraductal papillary mucinous neoplasms of the pancreas: a tissue microarray analysis.
Human pathology Feb, 2006 | Pubmed ID: 16426922
Serum and glucocorticoid-regulated protein kinases: variations on a theme.
Journal of cellular biochemistry Aug, 2006 | Pubmed ID: 16619268
IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.
Immunity May, 2006 | Pubmed ID: 16713974
Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3.
The Journal of biological chemistry Aug, 2006 | Pubmed ID: 16790420
Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration.
Trends in cell biology Sep, 2006 | Pubmed ID: 16870447
Glycogen synthase kinase-3--an overview of an over-achieving protein kinase.
Current drug targets Nov, 2006 | Pubmed ID: 17100578
Essential roles for GSK-3s and GSK-3-primed substrates in neurotrophin-induced and hippocampal axon growth.
Neuron Dec, 2006 | Pubmed ID: 17178402
Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link in the therapeutic action of lithium.
Journal of circadian rhythms , 2007 | Pubmed ID: 17295926
CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Ctheta, c-Rel, and protein kinase B.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2007 | Pubmed ID: 17312138
Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines.
Developmental cell Jun, 2007 | Pubmed ID: 17543867
Systematic discovery of in vivo phosphorylation networks.
Cell Jun, 2007 | Pubmed ID: 17570479
Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions.
Cells, tissues, organs , 2007 | Pubmed ID: 17587811
Glycogen synthase kinase-3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3.
The Journal of biological chemistry Oct, 2007 | Pubmed ID: 17711861
GSK-3beta controls osteogenesis through regulating Runx2 activity.
PloS one , 2007 | Pubmed ID: 17786208
Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism.
Cell metabolism Oct, 2007 | Pubmed ID: 17908561
Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Mar, 2008 | Pubmed ID: 18084253
Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.
PLoS biology Feb, 2008 | Pubmed ID: 18288891
Rationally designed PKA inhibitors for positron emission tomography: Synthesis and cerebral biodistribution of N-(2-(4-bromocinnamylamino)ethyl)-N-[11C]methyl-isoquinoline-5-sulfonamide.
Bioorganic & medicinal chemistry May, 2008 | Pubmed ID: 18346896
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2008 | Pubmed ID: 18367674
Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor?
Breast cancer research and treatment Mar, 2009 | Pubmed ID: 18438706
Glycogen synthase kinase-3beta heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results.
Behavioural pharmacology May, 2008 | Pubmed ID: 18469539
Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes.
The Journal of clinical investigation Jul, 2008 | Pubmed ID: 18551195
Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action.
Molecular and cellular biology Oct, 2008 | Pubmed ID: 18694957
Targeting glycogen synthase kinase-3 (GSK-3) in the treatment of Type 2 diabetes.
Expert opinion on therapeutic targets Oct, 2008 | Pubmed ID: 18781825
GSK-3beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism.
The Journal of clinical investigation Oct, 2008 | Pubmed ID: 18802478
Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation.
The Journal of clinical investigation Nov, 2008 | Pubmed ID: 18830417
Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development.
The Journal of biological chemistry Apr, 2009 | Pubmed ID: 19064989
Exploring pluripotency with chemical genetics.
Cell stem cell Feb, 2009 | Pubmed ID: 19200796
IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain.
Science signaling Feb, 2009 | Pubmed ID: 19244213
Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression.
Cancer research Jun, 2009 | Pubmed ID: 19491266
GSK-3 is a master regulator of neural progenitor homeostasis.
Nature neuroscience Nov, 2009 | Pubmed ID: 19801986
Abnormalities in brain structure and behavior in GSK-3alpha mutant mice.
Molecular brain , 2009 | Pubmed ID: 19925672
Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo.
Circulation research May, 2010 | Pubmed ID: 20360256
When pathways collide: collaboration and connivance among signalling proteins in development.
Nature reviews. Molecular cell biology Jun, 2010 | Pubmed ID: 20461097
Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.
Synapse (New York, N.Y.) Mar, 2011 | Pubmed ID: 20687111
Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility.
Hypertension Sep, 2010 | Pubmed ID: 20696985
Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival.
The Journal of biological chemistry Dec, 2010 | Pubmed ID: 20841359
Tissue-specific analysis of glycogen synthase kinase-3α (GSK-3α) in glucose metabolism: effect of strain variation.
PloS one , 2011 | Pubmed ID: 21253590
Does GSK-3 provide a shortcut for PI3K activation of Wnt signalling?
F1000 biology reports , 2010 | Pubmed ID: 21283602
Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation.
FEBS letters Apr, 2011 | Pubmed ID: 21419127
Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice.
Schizophrenia research Jun, 2011 | Pubmed ID: 21498050
Towards the preparation of radiolabeled 1-aryl-3-benzyl ureas: Radiosynthesis of [(11)C-carbonyl] AR-A014418 by [(11)C]CO(2) fixation.
Bioorganic & medicinal chemistry letters Jan, 2012 | Pubmed ID: 22321216
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