Rong Liu

Retroperitoneal laparoscopic hepatectomy: a novel approach.

Lithotomy using cholangioscopy via the left hepatic duct orifice versus the common bile duct in laparoscopic treatment of left-sided hepatolithiasis: a comparative study.

Single-port retroperitoneoscopic pancreatectomy: preliminary results from the first 3 patients.

Two anatomical pathways for retroperitoneoscopic pancreatectomy: indications for the posterior and lateral approaches.

Decreased RGS6 expression is associated with poor prognosis in pancreatic cancer patients.

Retroperitoneoscopic Anatomical Necrosectomy: A Modified Single-Stage Video-Assisted Retroperitoneal Approach for Treatment of Infected Necrotizing Pancreatitis.

Erratum to: Two Anatomical Pathways for Retroperitoneoscopic Pancreatectomy: Indications for the Posterior and Lateral Approaches.

[Preoperative neutrophil-lymphocyte ratio as an independent prognostic predictor for pancreatic cancer].

Gastric submucosa is inferior to the liver as transplant site for autologous islet transplantation in pancreatectomized diabetic Beagles.

An Improved Surgical Technique for Pure Laparoscopic Left Hemihepatectomy: Ten Years Experience in a Tertiary Center.

The surgical outcomes of robot-assisted laparoscopic pancreaticoduodenectomy versus laparoscopic pancreaticoduodenectomy for periampullary neoplasms: a comparative study of a single center.

The significance of low levels of LINC RP1130-1 expression in human hepatocellular carcinoma.

Expression and Prognostic Value of Indoleamine 2,3-dioxygenase in Pancreatic Cancer.

Robotic versus laparoscopic distal pancreatectomy: A propensity score-matched study.

First experience of robotic spleen-preserving distal pancreatectomy in a child with insulinoma.

[A single-team experience with robotic pancreatic surgery in 1010 cases].

Robotic resection of benign nonadrenal retroperitoneal tumors: A consecutive case series.

Short- and mid-term outcomes of robotic versus laparoscopic distal pancreatosplenectomy for pancreatic ductal adenocarcinoma: A retrospective propensity score-matched study.

Multivariate saturation treatment of malignant tumor.

An EPR-independent therapeutic strategy: Cancer cell-mediated dual-drug delivery depot for diagnostics and prevention of hepatocellular carcinoma metastasis.

Worldwide diffusion of robotic approach in general surgery.

Perioperative and long-term outcomes of robot-assisted versus laparoscopy-assisted hemicolectomy for left-sided colon cancers: a retrospective study.

The standardized technique in robotic radical antegrade modular pancreatosplenectomy using the flip-up approach.

First two-stage robotic ALPPS in HCC patients with hepatic vein invasion: a step-by-step procedure from a clinical case.

A comparative study of end-to-end pancreatic anastomosis versus pancreaticojejunostomy after robotic central pancreatectomy.

A nomogram predicting overall survival in patients with non-metastatic pancreatic head adenocarcinoma after surgery: a population-based study.

A metabolism-related 4-lncRNA prognostic signature and corresponding mechanisms in intrahepatic cholangiocarcinoma.

Robotic versus open total pancreatectomy: a retrospective cohort study.

The standardized technique and surgical video of robotic pancreaticoduodenectomy at the Chinese PLA General Hospital.

Comparison of robotic and open pancreaticoduodenectomy for primary nonampullary duodenal adenocarcinoma: a retrospective cohort study.

Nab-paclitaxel plus S-1 with or without PD-1 inhibitor in pancreatic ductal adenocarcinoma with only hepatic metastases: a retrospective cohort study.

Comparison of robotic and laparoscopic liver resection in ordinary cases of left lateral sectionectomy.

PIWIL4 and SUPT5H combine to predict prognosis and immune landscape in intrahepatic cholangiocarcinoma.

Active targeted Janus nanoparticles enable anti-angiogenic drug combining chemotherapy agent to prevent postoperative hepatocellular carcinoma recurrence.

Step-by-step and orderly lowering of the height of inferior vena cava tumor thrombus is the key to robot-assisted thrombectomy for Mayo III/IV tumor thrombus.

Evaluating the learning curve of robotic radical antegrade modular pancreatosplenectomy: A retrospective cohort study.

Short- and long-term outcomes after robotic and open liver resection for elderly patients with hepatocellular carcinoma: a propensity score-matched study.

Robotic versus open pancreaticoduodenectomy for distal cholangiocarcinoma: a multicenter propensity score-matched study.

[Effect of calpain on the degradation of tau protein in rat brain cortex extracts].

Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms.

Inhibition of melatonin biosynthesis induces neurofilament hyperphosphorylation with activation of cyclin-dependent kinase 5.

[Correlation of RCAS1 expression to human papillomavirus 16 (HPV16) infection in cervical cancer].

[Expressions of receptor-binding cancer antigen expressed on SiSo cells, vascular endothelial growth factor, and matrix metalloproteinase-9 in cervical carcinoma and correlation thereof with the invasion and metastasis of the cancerous tissues].

Dehydroevodiamine attenuates calyculin A-induced tau hyperphosphorylation in rat brain slices.

[Realgar nanometer suspension inducing apoptosis of Siha cell and its effect on expression of HPVE6/E7 oncogene].

Induction of SiHa cells apoptosis by nanometer realgar suspension and its mechanism.

Identifying protein-protein interaction sites in transient complexes with temperature factor, sequence profile and accessible surface area.

Protein phosphatase 2A in Alzheimer's disease.

Evaluation of atrial septal defect using real-time three-dimensional echocardiography: comparison with surgical findings.

[Expression of glucocorticoid receptors alpha and beta in mononuclear cells of peripheral blood in patients with glucocorticoid-induced ocular hypertension].

Using support vector machine combined with post-processing procedure to improve prediction of interface residues in transient complexes.

Assessment of myocardial perfusion and systolic function in patients with coronary artery disease after coronary artery bypass surgery by myocardial contrast echocardiography and two-dimensional strain echocardiography.

Evaluation of short-axis and long-axis myocardial function with two-dimensional strain echocardiography in patients with different degrees of coronary artery stenosis.

Tau dephosphorylation potentiates apoptosis by mechanisms involving a failed dephosphorylation/activation of Bcl-2.

Tau overexpression inhibits cell apoptosis with the mechanisms involving multiple viability-related factors.

Functional characterization of 58-kilodalton inhibitor of protein kinase in protecting against diabetic retinopathy via the endoplasmic reticulum stress pathway.

Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells.

Expression of endoplasmic reticulum stress-related factors in the retinas of diabetic rats.

Endoplasmic reticulum stress-related factors protect against diabetic retinopathy.

Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A).

Management of morderate-to-severe Marcus-Gunn syndrome by anastomosis of levator and frontal muscles.

HOXA10 expression is decreased by testosterone in luteinized granulosa cells in vitro.

Adeno-associated virus-mediated gene delivery of the human ND4 complex I subunit in rabbit eyes.

Assessment of right ventricular function in recipient twin of twin to twin transfusion syndrome with speckle tracking echocardiography.

Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation.

High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling.

High-spatial-resolution isotropic three-dimensional fast-recovery fast spin-echo magnetic resonance dacryocystography combined with topical administration of sterile saline solution.

Effect of cytotoxic T-lymphocyte-associated protein 4 on CD4(+)CD25(+) regulatory T cells in murine schistosomiasis japonica.

TWEAK/Fn14 pathway is a novel mediator of retinal neovascularization.

Fiber-based flexible all-solid-state asymmetric supercapacitors for integrated photodetecting system.

Helicobacter pylori filtrate impairs spatial learning and memory in rats and increases β-amyloid by enhancing expression of presenilin-2.

Nicotine accelerates diabetes-induced retinal changes.

Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats.

Helicobacter pylori filtrate induces Alzheimer-like tau hyperphosphorylation by activating glycogen synthase kinase-3β.

AMPK activation ameliorates Alzheimer's disease-like pathology and spatial memory impairment in a streptozotocin-induced Alzheimer's disease model in rats.

Diagnosis and treatment of cholangiocarcinoma: a consensus from surgical specialists of China.

Oxidative stress induces endothelial cell senescence via downregulation of Sirt6.

Diagnostic performance of the three-dimensional fast spin echo-Cube sequence in comparison with a conventional imaging protocol in evaluation of the lachrymal drainage system.

TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy.

Isotropic three-dimensional fast spin-echo Cube magnetic resonance dacryocystography: comparison with the three-dimensional fast-recovery fast spin-echo technique.

A novel tacrine-dihydropyridine hybrid (-)SCR1693 induces tau dephosphorylation and inhibits Aβ generation in cells.

Zinc binds to and directly inhibits protein phosphatase 2A in vitro.

Novel application of vacuum sealing drainage with continuous irrigation of potassium permanganate for managing infective wounds of gas gangrene.

Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau.

Transient Receptor Potential-canonical 1 is Essential for Environmental Enrichment-Induced Cognitive Enhancement and Neurogenesis.

Galanthamine, Plicamine, and Secoplicamine Alkaloids from Zephyranthes candida and Their Anti-acetylcholinesterase and Anti-inflammatory Activities.

Lentiviral vector-mediated down-regulation of Notch1 in endometrial stem cells results in proliferation and migration in endometriosis.

Intrauterine administration of autologous peripheral blood mononuclear cells (PBMCs) activated by HCG improves the implantation and pregnancy rates in patients with repeated implantation failure: a prospective randomized study.

Lacrimal Duct Occlusion Is Associated with Infectious Keratitis.

Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation.

Nitrogen and sulfur co-doping of 3D hollow-structured carbon spheres as an efficient and stable metal free catalyst for the oxygen reduction reaction.

The Copper bis(thiosemicarbazone) Complex Cu(II)(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu.

Deviation analysis for C1/2 pedicle screw placement using a three-dimensional printed drilling guide.

Hierarchically Porous Electrocatalyst with Vertically Aligned Defect-Rich CoMoS Nanosheets for the Hydrogen Evolution Reaction in an Alkaline Medium.

Various Structured Molybdenum-based Nanomaterials as Advanced Anode Materials for Lithium ion Batteries.

Intervention using a novel biodegradable hollow stent containing polylactic acid-polyprolactone-polyethylene glycol complexes against lacrimal duct obstruction disease.

Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit.

Modeling Chronic Dacryocystitis in Rabbits by Nasolacrimal Duct Obstruction with Self-Curing Resin.

Zinc mediates the neuronal activity-dependent anti-apoptotic effect.

Ginkgo biloba Extract EGb761 Attenuates Hyperhomocysteinemia-induced AD Like Tau Hyperphosphorylation and Cognitive Impairment in Rats.

Acetylcholinesterase Inhibitory Alkaloids from the Whole Plants of Zephyranthes carinata.

Anatomy of autophagy: from the beginning to the end.

Sex Differences in the Cognitive and Hippocampal Effects of Streptozotocin in an Animal Model of Sporadic AD.

High salt induced hypertension leads to cognitive defect.

Long-term Helicobacter pylori infection does not induce tauopathy and memory impairment in SD rats.

Three dimensional orbital magnetic resonance T2-mapping in the evaluation of patients with Graves' ophthalmopathy.

BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease.

Mixed Reality Technology-Assisted Orthopedics Surgery Navigation.

Moringa Oleifera Alleviates Homocysteine-Induced Alzheimer's Disease-Like Pathology and Cognitive Impairments.

CK2 Phosphorylating I/SET Mediates Tau Pathology and Cognitive Impairment.

The Function of MicroRNAs in B-Cell Development, Lymphoma, and Their Potential in Clinical Practice.

Phosphorylation of SET mediates apoptosis via P53 hyperactivation and NM23-H1 nuclear import.

Mixed Reality Technology Launches in Orthopedic Surgery for Comprehensive Preoperative Management of Complicated Cervical Fractures.

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.

Sirt6 deficiency impairs corneal epithelial wound healing.

Application of Weighted Gene Co-Expression Network Analysis to Explore the Key Genes in Alzheimer's Disease.

Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke.

Pathological changes of the nasolacrimal duct in rabbit models of chronic dacryocystitis: correlation with lacrimal endoscopic findings.

Nanoparticles Based on Poly (β-Amino Ester) and HPV16-Targeting CRISPR/shRNA as Potential Drugs for HPV16-Related Cervical Malignancy.

CDT2-controlled cell cycle reentry regulates the pathogenesis of Alzheimer's disease.

Intranasal Insulin Prevents Anesthesia-induced Cognitive Impairments in Aged Mice.

Realgar, a traditional Chinese medicine, induces apoptosis of HPV16-positive cervical cells through a HPV16 E7-related pathway.

Methanolic extract of attenuates hyperhomocysteinemia induced AD-like pathology and cognitive impairments in rats.

The Simplified Carbapenem Inactivation Method (sCIM) for Simple and Accurate Detection of Carbapenemase-Producing Gram-Negative Bacilli.

Polysaccharide Attenuates Tau Hyperphosphorylation and Cognitive Impairments in hTau Infected Mice.

CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits.

Practice Patterns and Perioperative Outcomes of Laparoscopic Pancreaticoduodenectomy in China: A Retrospective Multicenter Analysis of 1029 Patients.

SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments.

Acrylic acid-grafted pre-plasma nanofibers for efficient removal of oil pollution from aquatic environment.

2-Amino-3,8-dimethylimidazo[4,5-]quinoxaline Alters Autophagosome Maturation, Cellular Lipidomic Profiles, and Expression of Core Pluripotent Factors.

International consensus statement on robotic hepatectomy surgery in 2018.

Cytological Immunostaining of HMGA2, LRP1B, and TP63 as Potential Biomarkers for Triaging Human Papillomavirus-Positive Women.

Bisphenol A inhibits autophagosome-lysosome fusion and lipid droplet degradation.

Genistein Decreases APP/tau Phosphorylation and Ameliorates Aβ Overproduction Through Inhibiting CIP2A.

GSK-3β and ERK1/2 incongruously act in tau hyperphosphorylation in SPS-induced PTSD rats.

Medial Rectus Anastomosis Under Endoscopic Endonasal Orbital Approach With Image-Guided Navigation: A New Way of Repairing a Ruptured Medial Rectus.

Feasibility of mixed reality-based intraoperative three-dimensional image-guided navigation for atlanto-axial pedicle screw placement.

Corrigendum: Sex Differences in the Cognitive and Hippocampal Effects of Streptozotocin in an Animal Model of Sporadic AD.

Syntaxin-17-Dependent Mitochondrial Dynamics is Essential for Protection Against Oxidative-Stress-Induced Apoptosis.

The Rapid Carbapenemase Detection Method (rCDM) for Rapid and Accurate Detection of Carbapenemase-Producing and .

Characteristics of lacrimal passage diseases by 80-MHz ultrasound biomicroscopy: an observational study.

All-Day Thermogalvanic Cells for Environmental Thermal Energy Harvesting.

Posterior Vertebrectomy via the Unilateral Pedicle or Bilateral Pedicle Approach in the Treatment of Lumber Burst Fracture with Neurological Deficits: A Comparative Retrospective Cohort Study.

Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.

Protein Phosphatase 2A as a Drug Target in the Treatment of Cancer and Alzheimer's Disease.

Differences between meropenem and imipenem disk to detect carbapenemase in gram-negative bacilli using simplified carbapenem inactivation method.

Erratum to: Protein Phosphatase 2A as a Drug Target in the Treatment of Cancer and Alzheimer's Disease.

ω-3PUFAs Improve Cognitive Impairments Through Ser133 Phosphorylation of CREB Upregulating BDNF/TrkB Signal in Schizophrenia.

Phthiriasis palpebrarum, thelaziasis, and ophthalmomyiasis.

CD8CD57 T cells exhibit distinct features in human non-small cell lung cancer.

MicroRNA-21-3p accelerates diabetic wound healing in mice by downregulating SPRY1.

polysaccharide attenuates Aβ toxicity and cognitive defects in APP/PS1 mice.

Nedd4l downregulation of NRG1 in the mPFC induces depression-like behaviour in CSDS mice.

Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease.

Thermosensitive crystallization-boosted liquid thermocells for low-grade heat harvesting.

Blockage of AEP attenuates TBI-induced tau hyperphosphorylation and cognitive impairments in rats.

Ocular Manifestations and Clinical Implications of Serum Immunoglobulin G4 Levels in Graves' Ophthalmopathy Patients.

Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice.

Single-cell RNA sequencing reveals heterogeneity and differential expression of decidual tissues during the peripartum period.

Advances in Drug Therapy for Alzheimer's Disease.

The microbiologic spectrum of dacryocystitis.

Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition).

A circuit of mossy cells controls the efficacy of memory retrieval by Gria2I inhibition of Gria2.

Identification of comprehensive geriatric assessment-based risk factors for insomnia in elderly Chinese hospitalized patients.

An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma.

Charge-Gradient Hydrogels Enable Direct Zero Liquid Discharge for Hypersaline Wastewater Management.

Genome-Wide Screen and Validation of Microglia Pro-Inflammatory Mediators in Stroke.

Imaging and anatomical parameters of the lacrimal punctum and vertical canaliculus using optical coherence tomography.

Expression of SARS-CoV-2 entry genes ACE2 and TMPRSS2 at single cell resolution in the peripartum decidua.

Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.

Prevalence and the factors associated with malnutrition risk in elderly Chinese inpatients.

Gene Manipulation Protocols in Autophagy.

ESR1 mediated circ_0004018 suppresses angiogenesis in hepatocellular carcinoma via recruiting FUS and stabilizing TIMP2 expression.

Eye-Preserving Therapies for Advanced Retinoblastoma: A Multicenter Cohort of 1678 Patients in China.

Contemporary Update of Retinoblastoma in China: Three-Decade Changes in Epidemiology, Clinical Features, Treatments, and Outcomes.

Zinc induces reactive astrogliosis through ERK-dependent activation of Stat3 and promotes synaptic degeneration.

Application of Machine Learning and Weighted Gene Co-expression Network Algorithm to Explore the Hub Genes in the Aging Brain.

YTHDF1 promotes mRNA degradation via YTHDF1-AGO2 interaction and phase separation.

Biomarkers used in Alzheimer's disease diagnosis, treatment, and prevention.

Associations Between Fundus Types and Clinical Manifestations in Patients with RDH12 Gene Mutations.

Limbal Bio-Engineered Tissue Employing 3D Nanofiber-Aerogel Scaffold to Facilitate LSCs Growth and Migration.

YB-1 is a positive regulator of KLF5 transcription factor in basal-like breast cancer.

ChK1 activation induces reactive astrogliosis through CIP2A/PP2A/STAT3 pathway in Alzheimer's disease.

Tau Ubiquitination in Alzheimer's Disease.

Applications of Mixed Reality Technology in Orthopedics Surgery: A Pilot Study.

Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling.

Mechanical behaviour and microstructural evolution of Ni-based single crystal alloys under shock loading.

Defective mitophagy and the etiopathogenesis of Alzheimer's disease.

Early Prediction Model for Critical Illness of Hospitalized COVID-19 Patients Based on Machine Learning Techniques.

Zinc in Regulating Protein Kinases and Phosphatases in Neurodegenerative Diseases.

Phosphorylation of Truncated Tau Promotes Abnormal Native Tau Pathology and Neurodegeneration.

USP10 deubiquitinates Tau, mediating its aggregation.

The Therapeutic Effects of Seven Lycopodium Compounds on Cell Models of Alzheimer's Disease.

Rifaximin protects against circadian rhythm disruption-induced cognitive impairment through preventing gut barrier damage and neuroinflammation.

Green-Manufactured and Recyclable Coatings for Subambient Daytime Radiative Cooling.

Novel small molecular compound 2JY-OBZ4 alleviates AD pathology in cell models via regulating multiple targets.

Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice.

CIP2A deficiency promotes depression-like behaviors in mice through inhibition of dendritic arborization.

HIF-1α Causes LCMT1/PP2A Deficiency and Mediates Tau Hyperphosphorylation and Cognitive Dysfunction during Chronic Hypoxia.

Newly Detected Transmission of bla by Outer Membrane Vesicles in Klebsiella Pneumoniae.

Utility of isolated-check visual evoked potential technique in dysthyroid optic neuropathy.

Correction to: Utility of isolated‑check visual evoked potential technique in dysthyroid optic neuropathy.

Inactivation of ERK1/2-CREB Pathway Is Implicated in MK801-induced Cognitive Impairment.

Textbook outcome as a composite outcome measure in laparoscopic pancreaticoduodenectomy: a multicenter retrospective cohort study.

Propensity-score Matched and Coarsened-exact Matched Analysis Comparing Robotic and Laparoscopic Major Hepatectomies: An International Multicenter Study of 4822 Cases.

Ferulic Acid Improves Synaptic Plasticity and Cognitive Impairments by Alleviating the PP2B/DARPP-32/PP1 Axis-Mediated STEP Increase and Aβ Burden in Alzheimer's Disease.

Safety and Effectiveness of Rasburicase in the Control of Hyperuricemia in Pediatric Patients with Non-Hodgkin's Lymphoma and Acute Leukemia: An Open-Label, Single-Arm, Multi-center, Interventional Study.

Impact of body mass index on the difficulty and outcomes of laparoscopic left lateral sectionectomy.

Microglia activation mediates circadian rhythm disruption-induced cognitive impairment in mice.

Switchable Kirigami Structures as Window Envelopes for Energy-Efficient Buildings.

Impact of body mass index on perioperative outcomes of laparoscopic major hepatectomies.

Impact of liver cirrhosis, the severity of cirrhosis, and portal hypertension on the outcomes of minimally invasive left lateral sectionectomies for primary liver malignancies.

C9orf72 poly-PR helps p53 escape from the ubiquitin-proteasome system and promotes its stability.

Propensity Score-Matching Analysis Comparing Robotic Versus Laparoscopic Limited Liver Resections of the Posterosuperior Segments: An International Multi-Center Study.

Impact of liver cirrhosis and portal hypertension on minimally invasive limited liver resection for primary liver malignancies in the posterosuperior segments: An international multicenter study.

International experts consensus guidelines on robotic liver resection in 2023.

The impact of journal clubs on postgraduate medical education in China.

Diverse ultrasound image features of unilateral genital tract obstruction with ipsilateral renal anomaly syndrome on genitourinary system segmental sequential ultrasound screening and the accuracy of ultrasonic diagnosis.

Molecular regulatory mechanism of human myosin-7a.