Cameron S. Metcalf

Increased dietary sodium enhances activation of neurons in the medullary cardiovascular pathway during acute sodium loading in the rat.

Increased dietary sodium alters Fos expression in the lamina terminalis during intravenous angiotensin II infusion.

Differential regional effects of methamphetamine on dopamine transport.

Status epilepticus produces chronic alterations in cardiac sympathovagal balance.

Status epilepticus induces cardiac myofilament damage and increased susceptibility to arrhythmias in rats.

Autonomic and cellular mechanisms mediating detrimental cardiac effects of status epilepticus.

Incorporation of monodisperse oligoethyleneglycol amino acids into anticonvulsant analogues of galanin and neuropeptide y provides peripherally acting analgesics.

Analgesic properties of a peripherally acting and GalR2 receptor-preferring galanin analog in inflammatory, neuropathic, and acute pain models.

Preclinical evaluation of intravenous NAX 810-2, a novel GalR2-preferring analog, for anticonvulsant efficacy and pharmacokinetics.

Efficacy of mGlu -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures.

Preclinical Analgesic and Safety Evaluation of the GalR2-preferring Analog, NAX 810-2.

Development and pharmacologic characterization of the rat 6 Hz model of partial seizures.

Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP).

Novel Targets for Developing Antiseizure and, Potentially, Antiepileptogenic Drugs.

Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model.

Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugs.

Music-Enhanced Analgesia and Antiseizure Activities in Animal Models of Pain and Epilepsy: Toward Preclinical Studies Supporting Development of Digital Therapeutics and Their Combinations With Pharmaceutical Drugs.

Evaluation of antiseizure drug efficacy and tolerability in the rat lamotrigine-resistant amygdala kindling model.

The current approach of the Epilepsy Therapy Screening Program contract site for identifying improved therapies for the treatment of pharmacoresistant seizures in epilepsy.

Discovery of the First Vitamin K Analogue as a Potential Treatment of Pharmacoresistant Seizures.

Evaluation of subchronic administration of antiseizure drugs in spontaneously seizing rats.

Entrapping bupivacaine-loaded emulsions in a crosslinked-hydrogel increases anesthetic effect and duration in a rat sciatic nerve block model.

Accurate detection of spontaneous seizures using a generalized linear model with external validation.

Preventing neuronal edema increases network excitability after traumatic brain injury.

Cannabidiolic acid exhibits entourage-like improvements of anticonvulsant activity in an acute rat model of seizures.

Response: Usefulness of the post-kainate spontaneous recurrent seizure model for screening for antiseizure and for neuroprotective effects.

Development of an antiseizure drug screening platform for Dravet syndrome at the NINDS contract site for the Epilepsy Therapy Screening Program.

Screening of prototype antiseizure and anti-inflammatory compounds in the Theiler's murine encephalomyelitis virus model of epilepsy.

Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs.

Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor.

Precision medicine for genetic epilepsy on the horizon: recent advances, present challenges and suggestions for continued progress.