Massimo Levrero

Control of cccDNA function in hepatitis B virus infection.

Replicative and transcriptional activities of hepatitis B virus in patients coinfected with hepatitis B and hepatitis delta viruses.

Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2.

Transcriptional regulation of miR-224 upregulated in human HCCs by NFκB inflammatory pathways.

IL28B polymorphisms influence stage of the liver fibrosis and spontaneousor interferon-induced viral clearance in thalassemia patients with hepatitis C virus infection.

IFN-α inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome.

The HMGA1 protoncogene frequently deregulated in cancer is a transcriptional target of E2F1.

Molecular mechanisms of HBV-associated hepatocarcinogenesis.

TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.

Towards an HBV cure: state-of-the-art and unresolved questions--report of the ANRS workshop on HBV cure.

Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes.

IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome.

Mechanisms of HBV-induced hepatocellular carcinoma.

Aiming for cure in HBV and HDV infection.

Current treatments for chronic hepatitis B virus infections.

The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells.

HBV cure: why, how, when?

Intrahepatic innate immune response pathways are downregulated in untreated chronic hepatitis B.

Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B.

Genome-wide identification of direct HBx genomic targets.

Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities.

Challenges to a Cure for HBV Infection.

Combining amplicon sequencing and metabolomics in cirrhotic patients highlights distinctive microbiota features involved in bacterial translocation, systemic inflammation and hepatic encephalopathy.

Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model.

Serum hepatitis B core-related antigen (HBcrAg) correlates with covalently closed circular DNA transcriptional activity in chronic hepatitis B patients.

A global scientific strategy to cure hepatitis B.

EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells.