Michele Simbolo

High-throughput mutation profiling identifies novel molecular dysregulation in high-grade intraepithelial neoplasia and early gastric cancers.

High-throughput mutation profiling improves diagnostic stratification of sporadic medullary thyroid carcinomas.

Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups.

Reporting tumor molecular heterogeneity in histopathological diagnosis.

Complete remission with sunitinib in a poor-risk patient with metastatic renal cell carcinoma: the fine balance between toxicity and efficacy.

Next-generation sequencing for genetic testing of familial colorectal cancer syndromes.

A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics.

New genomic landscapes and therapeutic targets for biliary tract cancers.

BRCA somatic and germline mutation detection in paraffin embedded ovarian cancers by next-generation sequencing.

Lung neuroendocrine tumours: deep sequencing of the four World Health Organization histotypes reveals chromatin-remodelling genes as major players and a prognostic role for TERT, RB1, MEN1 and KMT2D.

Whole-genome landscape of pancreatic neuroendocrine tumours.

Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.

Most high-grade neuroendocrine tumours of the lung are likely to secondarily develop from pre-existing carcinoids: innovative findings skipping the current pathogenesis paradigm.

Frequent fusions in Caucasian pulmonary mucinous adenocarcinoma predicted by Phospho-ErbB3 expression.

Genetic alterations analysis in prognostic stratified groups identified TP53 and ARID1A as poor clinical performance markers in intrahepatic cholangiocarcinoma.

Centrosome Linker-induced Tetraploid Segregation Errors Link Rhabdoid Phenotypes and Lethal Colorectal Cancers.

Metformin Enhances Cisplatin-Induced Apoptosis and Prevents Resistance to Cisplatin in Co-mutated KRAS/LKB1 NSCLC.

ERG alterations and mTOR pathway activation in primary prostate carcinomas developing castration-resistance.

Mutational and copy number asset of primary sporadic neuroendocrine tumors of the small intestine.

Molecular alterations associated with metastases of solid pseudopapillary neoplasms of the pancreas.

Perineural Invasion is a Strong Prognostic Moderator in Ampulla of Vater Carcinoma: A Meta-analysis.

Gene Expression Profiling of Lung Atypical Carcinoids and Large Cell Neuroendocrine Carcinomas Identifies Three Transcriptomic Subtypes with Specific Genomic Alterations.

Patterns of gene mutations in bile duct cancers: is it time to overcome the anatomical classification?

Exploring the molecular and biological background of lung neuroendocrine tumours.

Ultra-Mutation in Wild-Type Glioblastomas of Patients Younger than 55 Years is Associated with Defective Mismatch Repair, Microsatellite Instability, and Giant Cell Enrichment.

Glioblastoma with tumor-to-tumor metastasis from lung adenocarcinoma.