Changyu Zheng

Long-term expression after infection by the hybrid vector AdLTR-luc is from integrated transgene.

Gene transfer to salivary glands.

Integration efficiency of a hybrid adenoretroviral vector.

Distribution and toxicity resulting from adenoviral vector administration to a single salivary gland in adult rats.

Inclusion of Moloney murine leukemia virus elements upstream of the transgene cassette in an E1-deleted adenovirus leads to an unusual genomic integration in epithelial cells.

Advances in vector-mediated gene transfer.

Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics.

Combined alpha tumor necrosis factor gene therapy and engineered dendritic cell vaccine in combating well-established tumors.

Intratumoral administration of immature dendritic cells following the adenovirus vector encoding CD40 ligand elicits significant regression of established myeloma.

Salivary glands as a potential gene transfer target for gene therapeutics of some monogenetic endocrine disorders.

Significant tumor regression induced by microencapsulation of recombinant tumor cells secreting fusion protein.

Evaluation of viral and mammalian promoters for use in gene delivery to salivary glands.

Vaccine of engineered tumor cells secreting stromal cell-derived factor-1 induces T-cell dependent antitumor responses.

Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction.

Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland.

Adeno-associated virus serotype 2-mediated gene transfer to the parotid glands of nonhuman primates.

Female mice are more susceptible to developing inflammatory disorders due to impaired transforming growth factor beta signaling in salivary glands.

Sorting of transgenic secretory proteins in miniature pig parotid glands following adenoviral-mediated gene transfer.

Adeno-associated virus type 12 (AAV12): a novel AAV serotype with sialic acid- and heparan sulfate proteoglycan-independent transduction activity.

Sorting behavior of a transgenic erythropoietin-growth hormone fusion protein in murine salivary glands.

Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements.

Evaluation of promoters for use in tissue-specific gene delivery.

Sorting of growth hormone-erythropoietin fusion proteins in rat salivary glands.

Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer.

Aquaporin-1 gene transfer to correct radiation-induced salivary hypofunction.

Long-term transduction of miniature pig parotid glands using serotype 2 adeno-associated viral vectors.

In vivo secretion of the mouse immunoglobulin G Fc fragment from rat submandibular glands.

Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cDNA to mouse submandibular glands.

Adenoviral mediated transduction of adenoid cystic carcinoma by human TRAIL gene driven with hTERT tumor specific promoter induces apoptosis.

Development of a gene transfer-based treatment for radiation-induced salivary hypofunction.

Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland.

Production and sorting of transgenic, modified human parathyroid hormone in vivo in rat salivary glands.

Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function.

Salivary epithelial cells: an unassuming target site for gene therapeutics.

Systemic delivery of bioactive glucagon-like peptide 1 after adenoviral-mediated gene transfer in the murine salivary gland.

Gene therapy of salivary diseases.

Effect of irradiation on microvascular endothelial cells of parotid glands in the miniature pig.

Prevention of radiation-induced salivary hypofunction following hKGF gene delivery to murine submandibular glands.

Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands.

Pharmacological Protection from Radiation ± Cisplatin-induced Oral Mucositis.

Antitumor effect of human TRAIL on adenoid cystic carcinoma using magnetic nanoparticle-mediated gene expression.

Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane.

Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes.

A novel hybrid adenoretroviral vector with more extensive E3 deletion extends transgene expression in submandibular glands.

Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction.

Impairment of TRPC1-STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1.

Recovery of radiation-induced dry eye and corneal damage by pretreatment with adenoviral vector-mediated transfer of erythropoietin to the salivary glands in mice.

Loss of TRPM2 function protects against irradiation-induced salivary gland dysfunction.

Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice.

Expression and secretion of human proinsulin-B10 from mouse salivary glands: implications for the treatment of type I diabetes mellitus.

miR-150 promotes renal fibrosis in lupus nephritis by downregulating SOCS1.

Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo.

Enhancement of osteoinduction by continual simvastatin release from poly(lactic-co-glycolic acid)-hydroxyapatite-simvastatin nano-fibrous scaffold.

Antitumor effect of TRAIL on oral squamous cell carcinoma using magnetic nanoparticle-mediated gene expression.

Toxicity and biodistribution of the serotype 2 recombinant adeno-associated viral vector, encoding Aquaporin-1, after retroductal delivery to a single mouse parotid gland.

All human EF1α promoters are not equal: markedly affect gene expression in constructs from different sources.

Efficiently engineered cell sheet using a complex of polyethylenimine-alginate nanocomposites plus bone morphogenetic protein 2 gene to promote new bone formation.

Integration of the hybrid adenoretroviral vector AdLTR-luc involves both MoMLV elements flanking the transgene.

Assessment of transfection of AdCMV-EGFP to rat submandibular gland cells.

STIM2 enhances receptor-stimulated Ca²⁺ signaling by promoting recruitment of STIM1 to the endoplasmic reticulum-plasma membrane junctions.

Advances in salivary gland gene therapy - oral and systemic implications.

Inhibition of autophagy by 3-MA enhances IL-24-induced apoptosis in human oral squamous cell carcinoma cells.

Essential role of carbonic anhydrase XII in secretory gland fluid and HCO3 (-) secretion revealed by disease causing human mutation.

Effects of human vascular endothelial growth factor on reparative dentin formation.