David J. Harrison

Glutathione and p53 independently mediate responses against oxidative stress in ES cells.

Counting alleles to predict recurrence of early-stage colorectal cancers.

Lack of health insurance and overall health.

Functional analysis of mouse hepatocytes differing in DNA content: volume, receptor expression, and effect of IFNgamma.

Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes.

Genetic interactions between the Wilms' tumor 1 gene and the p53 gene.

Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest.

Stem cell factor attenuates liver damage in a murine model of acetaminophen-induced hepatic injury.

Expression of the developmental Sonic hedgehog (Shh) signalling pathway is up-regulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes.

MBD1, MBD2 and CGBP genes at chromosome 18q21 are infrequently mutated in human colon and lung cancers.

Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion.

Cyclin D1 and p21 in ulcerative colitis-related inflammation and epithelial neoplasia: a study of aberrant expression and underlying mechanisms.

Thermal denaturation of spinach plastocyanin: effect of copper site oxidation state and molecular oxygen.

TNF-alpha induced DNA damage in primary murine hepatocytes.

While K-ras is essential for mouse development, expression of the K-ras 4A splice variant is dispensable.

Additive effect of p53, p21 and Rb deletion in triple knockout primary hepatocytes.

Reducing exposure to laboratory animal allergens.

Functional Smoothened is required for expression of GLI3 in colorectal carcinoma cells.

Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia.

p21(Waf1/Cip1) regulates proliferation and apoptosis in airway epithelial cells and alternative forms have altered binding activities.

Potential of hematopoietic stem cell therapy in hepatology: a critical review.

Induction of p21 and nuclear accumulation of TAp73alpha and c-abl during apoptosis of cisplatin-treated primary pancreatic acinar cells.

Improved retention of zymogen granules in cultured murine pancreatic acinar cells and induction of acinar-ductal transdifferentiation in vitro.

p53 deficiency exacerbates pleiotropic mitotic defects, changes in nuclearity and polyploidy in transdifferentiating pancreatic acinar cells.

Pharmacoeconomic analysis of sertraline treatment of depression in patients with unstable angina or a recent myocardial infarction.

Integrin characterization in pulmonary bronchioles.

ERbeta isoform expression in colorectal carcinoma: an in vivo and in vitro study of clinicopathological and molecular correlates.

Hematopoietic stem cell trafficking in liver injury.

Impact of atypical antipsychotics on outcomes of care in schizophrenia.

The K-Ras 4A isoform promotes apoptosis but does not affect either lifespan or spontaneous tumor incidence in aging mice.

Relationship between preventative physical health care and mental health in individuals with schizophrenia: a survey of caregivers.

Effect of initial ziprasidone dose on length of therapy in schizophrenia.

Effect of initial ziprasidone dose on treatment persistence in schizophrenia.

Growth factor attenuation of IFNgamma-mediated hepatocyte apoptosis requires p21waf-1.

Change in framingham risk score in patients with schizophrenia: a post hoc analysis of a randomized, double-blind, 6-week trial of ziprasidone and olanzapine.

Microarray analysis of gene expression of mouse hepatocytes of different ploidy.

Deficiency of G1 regulators P53, P21Cip1 and/or pRb decreases hepatocyte sensitivity to TGFbeta cell cycle arrest.

Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1tmT396).

Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis.

Dynamic computational modeling in the search for better breast cancer drug therapy.

Truncation of MBD4 predisposes to reciprocal chromosomal translocations and alters the response to therapeutic agents in colon cancer cells.

The cost of treating skeletal-related events in patients with prostate cancer.

TGFbeta induces apoptosis and EMT in primary mouse hepatocytes independently of p53, p21Cip1 or Rb status.

Beta1 integrin in tissue remodelling and repair: from phenomena to concepts.

Attaching and effacing Escherichia coli downregulate DNA mismatch repair protein in vitro and are associated with colorectal adenocarcinomas in humans.

WWOX gene expression abolishes ovarian cancer tumorigenicity in vivo and decreases attachment to fibronectin via integrin alpha3.

Structure, properties, and engineering of the major zinc binding site on human albumin.

The impact of itch symptoms in psoriasis: results from physician interviews and patient focus groups.

Systems pathology--taking molecular pathology into a new dimension.

Systems biology reveals new strategies for personalizing cancer medicine and confirms the role of PTEN in resistance to trastuzumab.

Modulation of HER3 is a marker of dynamic cell signaling in ovarian cancer: implications for pertuzumab sensitivity.

How can systems pathology help us personalize cancer therapy?

The importance of growth factors and steroid hormones in ovarian cancer.

Prognostic relevance of DNA copy number changes in colorectal cancer.

Bone marrow stem cells contribute to alcohol liver fibrosis in humans.

Comparison of methods for measuring dose escalation of the subcutaneous TNF antagonists for rheumatoid arthritis patients treated in routine clinical practice.

Etanercept treatment patterns in managed-care patients with psoriasis or psoriatic arthritis.

Pertuzumab for the treatment of ovarian cancer.

Independent regulation of P53 stabilisation and activation after Rb deletion in primary epithelial cells.

Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer.

Validation and response to treatment of a pruritus self-assessment tool in patients with moderate to severe psoriasis.

Dosing patterns and costs of tumor necrosis factor inhibitor use for rheumatoid arthritis.

Cancer systems biology.

Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells.

Orphan CpG islands identify numerous conserved promoters in the mammalian genome.

Compensatory effects in the PI3K/PTEN/AKT signaling network following receptor tyrosine kinase inhibition.

Phosphoprotein pathway profiling of ovarian carcinoma for the identification of potential new targets for therapy.

An in vitro model that recapitulates the epithelial to mesenchymal transition (EMT) in human breast cancer.

Routinely obtained diagnostic material as a source of RNA for personalized medicine in lung cancer patients.

Transcriptionally repressed genes become aberrantly methylated and distinguish tumors of different lineages in breast cancer.

Utilizing mRNA extracted from small, archival formalin-fixed paraffin-embedded prostate samples for translational research: assessment of the effect of increasing sample age and storage temperature.

An analytical approach differentiates between individual and collective cancer invasion.

What can molecular pathology contribute to the management of renal cell carcinoma?

Trastuzumab and pertuzumab produce changes in morphology and estrogen receptor signaling in ovarian cancer xenografts revealing new treatment strategies.

Two possible mechanisms of epithelial to mesenchymal transition in invasive ductal breast cancer.

Impaired sensitivity to Pavlovian stimulus-outcome learning after excitotoxic lesion of the ventrolateral neostriatum.

Sprouty 2 is an independent prognostic factor in breast cancer and may be useful in stratifying patients for trastuzumab therapy.

Health-related quality of life of pediatric patients with moderate to severe plaque psoriasis: comparisons to four common chronic diseases.

Features of the reversible sensitivity-resistance transition in PI3K/PTEN/AKT signalling network after HER2 inhibition.

Determining tamoxifen sensitivity using primary breast cancer tissue in collagen-based three-dimensional culture.

GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines.

Qualitative and quantitative MALDI imaging of the positron emission tomography ligands raclopride (a D2 dopamine antagonist) and SCH 23390 (a D1 dopamine antagonist) in rat brain tissue sections using a solvent-free dry matrix application method.

Model-based global sensitivity analysis as applied to identification of anti-cancer drug targets and biomarkers of drug resistance in the ErbB2/3 network.

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes.

Annual costs of tumor necrosis factor inhibitors using real-world data in a commercially insured population in the United States.

Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression.

The use of automated quantitative analysis to evaluate epithelial-to-mesenchymal transition associated proteins in clear cell renal cell carcinoma.

HER2 expression in ovarian carcinoma: caution and complexity in biomarker analysis.

Allosteric modulation of beta1 integrin function induces lung tissue repair.

Diversity of matriptase expression level and function in breast cancer.

Targeting of Rac GTPases blocks the spread of intact human breast cancer.

Conductive carbon tape used for support and mounting of both whole animal and fragile heat-treated tissue sections for MALDI MS imaging and quantitation.

Characterising the tumour morphological response to therapeutic intervention: an ex vivo model.

Clinical Utility of an Epigenetic Assay to Detect Occult Prostate Cancer in Histopathologically Negative Biopsies: Results of the MATLOC Study.

Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer.

Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns.

New strategies for targeting the hypoxic tumour microenvironment in breast cancer.

A model of estrogen-related gene expression reveals non-linear effects in transcriptional response to tamoxifen.