Arshad Desai

The minus end in sight.

Centriole assembly requires both centriolar and pericentriolar material proteins.

Kinetochore-spindle microtubule interactions during mitosis.

The CENP-F-like proteins HCP-1 and HCP-2 target CLASP to kinetochores to mediate chromosome segregation.

Distinct roles for two C. elegans anillins in the gonad and early embryo.

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling.

A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans.

Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F.

The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation.

Molecular analysis of mitotic chromosome condensation using a quantitative time-resolved fluorescence microscopy assay.

An FHA domain-mediated protein interaction network of Rad53 reveals its role in polarized cell growth.

A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension.

Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain.

Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin.

A role for Rab5 in structuring the endoplasmic reticulum.

KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates.

Expression and imaging of fluorescent proteins in the C. elegans gonad and early embryo.

The wages of CIN.

SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules.

A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex.

Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches.

Structural memory in the contractile ring makes the duration of cytokinesis independent of cell size.

The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation.

Analyzing the effects of delaying aster separation on furrow formation during cytokinesis in the Caenorhabditis elegans embryo.

Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells.

A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis.

A PSHaver for centromeric histones.

The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly.

A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue.

Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrest.

Acute drug treatment in the early C. elegans embryo.

Rapid de novo centromere formation occurs independently of heterochromatin protein 1 in C. elegans embryos.

Affinity purification of protein complexes in C. elegans.

Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates.

Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore.

An inverse relationship to germline transcription defines centromeric chromatin in C. elegans.

Hierarchical assembly of the eggshell and permeability barrier in C. elegans.

What the hec is up with mouse oocyte meiosis?

Tension sensing by Aurora B kinase is independent of survivin-based centromere localization.

Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly.

A two-step mechanism for epigenetic specification of centromere identity and function.

A conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesis.

Dominant Mutations in S. cerevisiae PMS1 Identify the Mlh1-Pms1 Endonuclease Active Site and an Exonuclease 1-Independent Mismatch Repair Pathway.

The midbody ring scaffolds the abscission machinery in the absence of midbody microtubules.

Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.

Meiotic double-strand breaks uncover and protect against mitotic errors in the C. elegans germline.

Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown.

Linked in: formation and regulation of microtubule attachments during chromosome segregation.

A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint.

Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae.

PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair.

A new piece in the kinetochore jigsaw puzzle.

The outer kinetochore protein KNL-1 contains a defined oligomerization domain in nematodes.

The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast.

Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors.

Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. elegans.

Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.

Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in C. elegans.

Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition.

Natural Loss of Mps1 Kinase in Nematodes Uncovers a Role for Polo-like Kinase 1 in Spindle Checkpoint Initiation.

NOCA-1 functions with γ-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans.

A Cell Biologist's Field Guide to Aurora Kinase Inhibitors.

A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions.

A TOGgle for Tension at Kinetochores.

53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration.

A Nucleoporin Docks Protein Phosphatase 1 to Direct Meiotic Chromosome Segregation and Nuclear Assembly.

A Molecular View of Kinetochore Assembly and Function.

How centrioles acquire the ability to reproduce.

An engineered minimal chromosomal passenger complex reveals a role for INCENP/Sli15 spindle association in chromosome biorientation.

Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex.

A toolkit for GFP-mediated tissue-specific protein degradation in .

Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System.

Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates.

Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans.

Taming the Beast: Control of APC/C-Dependent Destruction.

Meiosis: The Origins of Bias.

Cdc73 suppresses genome instability by mediating telomere homeostasis.

Employing the one-cell C. elegans embryo to study cell division processes.

Analyzing the micromechanics of the cell division apparatus.

A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in .

CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytia.

Promoting an "Auteur Theory" for Young Scientists: Preserving Excitement and Creativity ….

CFI-400945 is not a selective cellular PLK4 inhibitor.

The Kinetochore-Microtubule Coupling Machinery Is Repurposed in Sensory Nervous System Morphogenesis.

A high-content imaging approach to profile embryonic development.

Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan.

Ancestral roles of the Fam20C family of secreted protein kinases revealed in .