Karen Oegema

Closing the GAP: a role for a RhoA GAP in cytokinesis.

The minus end in sight.

Centriole assembly requires both centriolar and pericentriolar material proteins.

The CENP-F-like proteins HCP-1 and HCP-2 target CLASP to kinetochores to mediate chromosome segregation.

Distinct roles for two C. elegans anillins in the gonad and early embryo.

A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans.

Molecular analysis of mitotic chromosome condensation using a quantitative time-resolved fluorescence microscopy assay.

A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension.

Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin.

A role for Rab5 in structuring the endoplasmic reticulum.

MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor downregulation.

Cell division.

Expression and imaging of fluorescent proteins in the C. elegans gonad and early embryo.

SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules.

A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex.

Systematic analysis in Caenorhabditis elegans reveals that the spindle checkpoint is composed of two largely independent branches.

Structural memory in the contractile ring makes the duration of cytokinesis independent of cell size.

The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation.

Analyzing the effects of delaying aster separation on furrow formation during cytokinesis in the Caenorhabditis elegans embryo.

Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells.

A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis.

The chromosomal passenger complex and centralspindlin independently contribute to contractile ring assembly.

A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue.

Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrest.

Acute drug treatment in the early C. elegans embryo.

Rapid de novo centromere formation occurs independently of heterochromatin protein 1 in C. elegans embryos.

Affinity purification of protein complexes in C. elegans.

Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore.

An inverse relationship to germline transcription defines centromeric chromatin in C. elegans.

Cytokinesis in animal cells.

Hierarchical assembly of the eggshell and permeability barrier in C. elegans.

Direct binding of SAS-6 to ZYG-1 recruits SAS-6 to the mother centriole for cartwheel assembly.

A conserved RhoGAP limits M phase contractility and coordinates with microtubule asters to confine RhoA during cytokinesis.

The midbody ring scaffolds the abscission machinery in the absence of midbody microtubules.

Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation.

Meiotic double-strand breaks uncover and protect against mitotic errors in the C. elegans germline.

Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown.

A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint.

Structure of the C. elegans ZYG-1 cryptic polo box suggests a conserved mechanism for centriolar docking of Plk4 kinases.

The Caenorhabditis elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm before incorporation into the PCM matrix.

The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans.

The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast.

Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. elegans.

Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.

Centrosomes. Regulated assembly of a supramolecular centrosome scaffold in vitro.

NOCA-1 functions with γ-tubulin and in parallel to Patronin to assemble non-centrosomal microtubule arrays in C. elegans.

Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to promote C. elegans elongation.

A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions.

53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration.

Polo-like kinase phosphorylation determines Caenorhabditis elegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation.

A Nucleoporin Docks Protein Phosphatase 1 to Direct Meiotic Chromosome Segregation and Nuclear Assembly.

GOLPH3 drives cell migration by promoting Golgi reorientation and directional trafficking to the leading edge.

How centrioles acquire the ability to reproduce.

Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex.

A toolkit for GFP-mediated tissue-specific protein degradation in .

Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates.

TPXL-1 activates Aurora A to clear contractile ring components from the polar cortex during cytokinesis.

Employing the one-cell C. elegans embryo to study cell division processes.

A positive-feedback-based mechanism for constriction rate acceleration during cytokinesis in .

CYK-4 functions independently of its centralspindlin partner ZEN-4 to cellularize oocytes in germline syncytia.

CFI-400945 is not a selective cellular PLK4 inhibitor.

The ARP2/3 complex prevents excessive formin activity during cytokinesis.

The Kinetochore-Microtubule Coupling Machinery Is Repurposed in Sensory Nervous System Morphogenesis.

Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity.

Ancestral roles of the Fam20C family of secreted protein kinases revealed in .

The G2-to-M Transition Is Ensured by a Dual Mechanism that Protects Cyclin B from Degradation by Cdc20-Activated APC/C.