Robert Clarke

LCC15-MB cells are MDA-MB-435: a review of misidentified breast and prostate cell lines.

Common origins of MDA-MB-435 cells from various sources with those shown to have melanoma properties.

Role of Toll-like receptor-4 in genetic susceptibility to lung injury induced by residual oil fly ash.

Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis.

Stem cells and tissue homeostasis in mammary glands.

The mammary gland "side population": a putative stem/progenitor cell marker?

Transforming learning: the challenge of interprofessional education.

Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial.

The p160 family coactivators regulate breast cancer cell proliferation and invasion through autocrine/paracrine activity of SDF-1alpha/CXCL12.

Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations.

Homocysteine, B-vitamins, and the risk of cardiovascular disease.

Homocysteine-lowering trials for prevention of heart disease and stroke.

The application of an indicator based on taxonomic distinctness for UK marine biodiversity assessments.

Antiestrogens, aromatase inhibitors, and apoptosis in breast cancer.

Evaluation of the technical performance of novel holotranscobalamin (holoTC) assays in a multicenter European demonstration project.

Cholesterol, coronary heart disease and stroke: a review of published evidence from observational studies and randomized controlled trials.

Homocysteine and coronary heart disease.

Cause-specific mortality in old age in relation to body mass index in middle age and in old age: follow-up of the Whitehall cohort of male civil servants.

High Q-factor microwave Fabry-Perot resonator with distributed Bragg reflectors.

Human breast epithelial stem cells and their regulation.

Combined effects of systolic blood pressure and total cholesterol on cardiovascular disease risk.

Mechanisms mediating the effects of prepubertal (n-3) polyunsaturated fatty acid diet on breast cancer risk in rats.

Expression patterns among interferon regulatory factor-1, human X-box binding protein-1, nuclear factor kappa B, nucleophosmin, estrogen receptor-alpha and progesterone receptor proteins in breast cancer tissue microarrays.

Mechanisms of Disease: prediction and prevention of breast cancer--cellular and molecular interactions.

Multidrug resistance/P-glycoprotein and breast cancer: review and meta-analysis.

A psychosocial risk assessment and management framework to enhance response to CBRN terrorism threats and attacks.

Optimized multilayer perceptrons for molecular classification and diagnosis using genomic data.

Airborne infectious disease and the suppression of pulmonary bioaerosols.

Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population.

Meta-analysis of soy intake and breast cancer risk.

Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo.

AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines.

Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study.

Genome-wide mapping of susceptibility to coronary artery disease identifies a novel replicated locus on chromosome 17.

Regulation of the nuclear localization of the human Nedd4-related WWP1 protein by Notch.

Ovarian steroids and the human breast: regulation of stem cells and cell proliferation.

Vitamin B12, folic acid, and the prevention of dementia.

Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study.

Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving epidermal growth factor receptor and signal transducer and activator of transcription 5b.

Trans fatty acids and coronary heart disease.

Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial.

Shaping the pupil's response to light in the hooded rat.

High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic?

Estrogen receptor alpha positive breast tumors and breast cancer cell lines share similarities in their transcriptome data structures.

The use of a segmented transducer for rib sparing in HIFU treatments.

Effects of B-vitamins on plasma homocysteine concentrations and on risk of cardiovascular disease and dementia.

Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer.

Endocrine therapy resistance can be associated with high estrogen receptor alpha (ERalpha) expression and reduced ERalpha phosphorylation in breast cancer models.

Why inhaling salt water changes what we exhale.

Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity.

Homocysteine-lowering vitamin B supplements do not improve cognitive performance in healthy older adults after two years.

Homocysteine, B vitamins, and the risk of dementia.

Estrogen deprivation for breast cancer prevention.

Absence of relationship between MTTP haplotypes and longevity.

Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin.

Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways.

Survival in relation to angina symptoms and diagnosis among men aged 70-90 years: the Whitehall Study.

Homocysteine and cardiovascular risk: considering the evidence in the context of study design, folate fortification, and statistical power.

The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines.

The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people.

VISDA: an open-source caBIG analytical tool for data clustering and beyond.

Cholesterol fractions and apolipoproteins as risk factors for heart disease mortality in older men.

Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines.

Progressive loss of estrogen receptor alpha cofactor recruitment in endocrine resistance.

Gene selection for multiclass prediction by weighted Fisher criterion.

Origins of breast cancer subtypes and therapeutic implications.

B vitamins for the prevention of vascular disease: insufficient evidence to justify treatment.

Mammary stem cells and breast cancer--role of Notch signalling.

Inferring network interactions using recurrent neural networks and swarm intelligence.

Latent variable and nICA modeling of pathway gene module composite.

Classification algorithms for phenotype prediction in genomics and proteomics.

Low vitamin B-12 status and risk of cognitive decline in older adults.

Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p.

Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths.

The properties of high-dimensional data spaces: implications for exploring gene and protein expression data.

Newly identified loci that influence lipid concentrations and risk of coronary artery disease.

The exon 1-8C/G SNP in the PSMA6 gene contributes only a small amount to the burden of myocardial infarction in 6946 cases and 2720 controls from a United Kingdom population.

B-vitamins and prevention of dementia.

Biomarkers of inflammation predict both vascular and non-vascular mortality in older men.

Motif-directed network component analysis for regulatory network inference.

Folate and vitamin B12 status in relation to cognitive impairment and anaemia in the setting of voluntary fortification in the UK.

Network motif-based identification of transcription factor-target gene relationships by integrating multi-source biological data.

Cone and rod cells have different target preferences in vitro as revealed by optical tweezers.

Plasma homocysteine, but not folate or vitamin B-12, predicts mortality in older people in the United Kingdom.

The origin of estrogen receptor alpha-positive and alpha-negative breast cancer.

Response and resistance to the endocrine prevention of breast cancer.

A ground truth based comparative study on clustering of gene expression data.

Is "usual" blood pressure a proxy for 24-h ambulatory blood pressure in predicting cardiovascular outcomes?

Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial.

Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity.

Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial.

Discrepancy between inferior vena cava and right atrial oxygen saturations as a sign of ischemia in the mesenteric circulation.

caBIG VISDA: modeling, visualization, and discovery for cluster analysis of genomic data.

The removal of multiplicative, systematic bias allows integration of breast cancer gene expression datasets - improving meta-analysis and prediction of prognosis.

Knowledge-guided multi-scale independent component analysis for biomarker identification.

Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people.

B vitamins for prevention of cognitive decline: insufficient evidence to justify treatment.

ERRgamma mediates tamoxifen resistance in novel models of invasive lobular breast cancer.

Annotating breast cancer microarray samples using ontologies.

Are stem-like cells responsible for resistance to therapy in breast cancer?

Common variants at 30 loci contribute to polygenic dyslipidemia.

Plasma phospholipid fatty acids and CHD in older men: Whitehall study of London civil servants.

Differential dependency network analysis to identify condition-specific topological changes in biological networks.

Gene signaling pathways mediating the opposite effects of prepubertal low-fat and high-fat n-3 polyunsaturated fatty acid diets on mammary cancer risk.

Network motif-based identification of breast cancer susceptibility genes.

Risk factors for pancreatic cancer mortality: extended follow-up of the original Whitehall Study.

Vascular risk factors and cognitive function among 3763 participants in the Hypertension in the Very Elderly Trial (HYVET): a cross-sectional analysis.

Resistance to endocrine therapy: are breast cancer stem cells the culprits?

Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen.

Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies.

Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.

Genome-wide association study identifies eight loci associated with blood pressure.

Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cells.

The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls.

Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study.

Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer.

Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.

Reverse engineering module networks by PSO-RNN hybrid modeling.

The role of X-box binding protein-1 in tumorigenicity.

Biomarkers of dietary energy restriction in women at increased risk of breast cancer.

It's all in the details: methods in breast development and cancer.

Frequent loss of heterozygosity at the interferon regulatory factor-1 gene locus in breast cancer.

Life expectancy in relation to cardiovascular risk factors: 38 year follow-up of 19,000 men in the Whitehall study.

Gene module identification from microarray data using nonnegative independent component analysis.

Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.

Exploring the marine biotic index (AMBI): variations on a theme by Angel Borja.

The influence of EDTA and citrate anticoagulant addition to human plasma on information recovery from NMR-based metabolic profiling studies.

The role of preclinical animal models in breast cancer drug development.

Genetic variants associated with Lp(a) lipoprotein level and coronary disease.

Cross phenotype normalization of microarray data.

Biomarker identification by knowledge-driven multilevel ICA and motif analysis.

Identification of condition-specific regulatory modules through multi-level motif and mRNA expression analysis.

Co-inhibition of BCL-W and BCL2 restores antiestrogen sensitivity through BECN1 and promotes an autophagy-associated necrosis.

Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

BCL2 and CASP8 regulation by NF-kappaB differentially affect mitochondrial function and cell fate in antiestrogen-sensitive and -resistant breast cancer cells.

DBC-1 mediates endocrine resistant breast cancer cell survival.

Knowledge-guided gene ranking by coordinative component analysis.

Introducing a professional development framework for postgraduate medical supervisors in secondary care: considerations, constraints and challenges.

Multilevel support vector regression analysis to identify condition-specific regulatory networks.

The proapoptotic molecule BLID interacts with Bcl-XL and its downregulation in breast cancer correlates with poor disease-free and overall survival.

Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells.

Reconstruction of gene regulatory modules in cancer cell cycle by multi-source data integration.

IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis.

Saturated fat and heart disease.

Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial.

Orphan nuclear receptors in breast cancer pathogenesis and therapeutic response.

The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers.

Turnaround strategies.

Height loss and future coronary heart disease in London: the Whitehall II study.

Comprehensive CYP2D6 genotype and adherence affect outcome in breast cancer patients treated with tamoxifen monotherapy.

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals.

Breast cancer stem cells: something out of notching?

Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials.

Modifiable risk factors for prostate cancer mortality in London: forty years of follow-up in the Whitehall study.

PUGSVM: a caBIGâ„¢ analytical tool for multiclass gene selection and predictive classification.

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.

Lipoprotein(a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study.

Large-scale candidate gene analysis of HDL particle features.

DDN: a caBIG® analytical tool for differential network analysis.

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.

Commentary: Lipoprotein(a) and atherosclerosis.

Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer.

Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.

A randomised controlled trial investigating the effect of vitamin B12 supplementation on neurological function in healthy older people: the Older People and Enhanced Neurological function (OPEN) study protocol [ISRCTN54195799].

Motif-guided sparse decomposition of gene expression data for regulatory module identification.

Gamma-tocotrienol induced apoptosis is associated with unfolded protein response in human breast cancer cells.

No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study.

Physiological Responses to Near-Miss Outcomes and Personal Control During Simulated Gambling.

Aspects of benthic decapod diversity and distribution from rocky nearshore habitat at geographically widely dispersed sites.

Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts.

Overexpression of the dominant-negative form of interferon regulatory factor 1 in oligodendrocytes protects against experimental autoimmune encephalomyelitis.

Homocysteine, B vitamins, and the risk of cardiovascular disease.

Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells.

Breast cancer stem cells and their role in resistance to endocrine therapy.

Profile of Robert Clarke. Interviewed by Kristie Nybo, Ph.D.

Association of cognitive impairment with combinations of vitamin B₁₂-related parameters.

Vitamin E succinate inhibits survivin and induces apoptosis in pancreatic cancer cells.

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

Cannibalism, cell survival, and endocrine resistance in breast cancer.

The importance of reducing SFA to limit CHD.

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Dickkopf1 regulates fate decision and drives breast cancer stem cells to differentiation: an experimentally supported mathematical model.

Autophagy and endocrine resistance in breast cancer.

NTP-CERHR expert panel report on the developmental toxicity of soy infant formula.

G-DOC: a systems medicine platform for personalized oncology.

Identifying cancer biomarkers by network-constrained support vector machines.

The devil is in the methods: lineage tracing, functional screens and sequencing, hormones, tumour-stroma interactions, and expansion of human breast tumours as xenografts.

Blood pressure loci identified with a gene-centric array.

Response to hoenselaar from pedersen et Al.

Response to Ravnskov et al. on saturated fat and CHD.

Long-term weight loss and prevention of cardiovascular disease.

A genome-wide association search for type 2 diabetes genes in African Americans.

GIST: A Gibbs sampler to identify intracellular signal transduction pathways.

Influence of Berry-Polyphenols on Receptor Signaling and Cell-Death Pathways: Implications for Breast Cancer Prevention.

Lack of caveolin-1 (P132L) somatic mutations in breast cancer.

Large-Scale Gene-Centric Meta-Analysis across 39 studies Identifies Type 2 Diabetes Loci.