Michael X. Zhu

Rapid activation of protein tyrosine kinase and phospholipase C-gamma2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells.

A unified nomenclature for the superfamily of TRP cation channels.

Calmodulin regulates Ca(2+)-dependent feedback inhibition of store-operated Ca(2+) influx by interaction with a site in the C terminus of TrpC1.

Expression and role of TRPC proteins in human platelets: evidence that TRPC6 forms the store-independent calcium entry channel.

Epidermal growth factor-induced depletion of the intracellular Ca2+ store fails to activate capacitative Ca2+ entry in a human salivary cell line.

Characterization of a human peptide deformylase: implications for antibacterial drug design.

Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger.

TRPC channel interactions with calmodulin and IP3 receptors.

2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3.

An alternative splicing product of the murine trpv1 gene dominant negatively modulates the activity of TRPV1 channels.

Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion.

Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4.

2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels.

The selectivity filter of the cation channel TRPM4.

Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes.

Calmodulin and calcium interplay in the modulation of TRPC5 channel activity. Identification of a novel C-terminal domain for calcium/calmodulin-mediated facilitation.

Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4.

Cellular cholesterol controls TRPC3 function: evidence from a novel dominant-negative knockdown strategy.

Thermal sensitivity of isolated vagal pulmonary sensory neurons: role of transient receptor potential vanilloid receptors.

TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells.

Potentiation of TRPV3 channel function by unsaturated fatty acids.

Analogs of methyllycaconitine as novel noncompetitive inhibitors of nicotinic receptors: pharmacological characterization, computational modeling, and pharmacophore development.

The TRPV3 mutation associated with the hairless phenotype in rodents is constitutively active.

Beta-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle.

Understanding the role of voltage gating of polymodal TRP channels.

The axon-dendrite targeting of Kv3 (Shaw) channels is determined by a targeting motif that associates with the T1 domain and ankyrin G.

Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations.

Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate.

Sensorimotor enhancement in mouse mutants lacking the Purkinje cell-specific Gi/o modulator, Pcp2(L7).

Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery.

Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity.

Zinc activates damage-sensing TRPA1 ion channels.

NAADP mobilizes calcium from acidic organelles through two-pore channels.

The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.

Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo.

Potencies of cocaine methiodide on major cocaine targets in mice.

Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs.

Calcium signaling via two-pore channels: local or global, that is the question.

TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP.

Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.

Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity.

The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.

Two-pore channels for integrative Ca signaling.

Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors.

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+.

Agonist-activated Ca2+ influx occurs at stable plasma membrane and endoplasmic reticulum junctions.

An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell.

Cyclic adenosine diphosphate ribose activates ryanodine receptors, whereas NAADP activates two-pore domain channels.

Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.

Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes.

Ca2+: a versatile master key for intracellular signaling cascades.

Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.

TRPM8 acute desensitization is mediated by calmodulin and requires PIP(2): distinction from tachyphylaxis.

Hysteresis of gating underlines sensitization of TRPV3 channels.

Heteromeric heat-sensitive TRP channels exhibit distinct temperature and chemical response.