Department of Integrative Biology and Pharmacology
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Rapid activation of protein tyrosine kinase and phospholipase C-gamma2 and increase in cytosolic free calcium are required by Ehrlichia chaffeensis for internalization and growth in THP-1 cells.
Infection and immunity Feb, 2002 | Pubmed ID: 11796624
A unified nomenclature for the superfamily of TRP cation channels.
Molecular cell Feb, 2002 | Pubmed ID: 11864597
Calmodulin regulates Ca(2+)-dependent feedback inhibition of store-operated Ca(2+) influx by interaction with a site in the C terminus of TrpC1.
Molecular cell Apr, 2002 | Pubmed ID: 11983166
Expression and role of TRPC proteins in human platelets: evidence that TRPC6 forms the store-independent calcium entry channel.
Blood Oct, 2002 | Pubmed ID: 12351388
Epidermal growth factor-induced depletion of the intracellular Ca2+ store fails to activate capacitative Ca2+ entry in a human salivary cell line.
The Journal of biological chemistry Dec, 2002 | Pubmed ID: 12368284
Characterization of a human peptide deformylase: implications for antibacterial drug design.
Biochemistry Aug, 2003 | Pubmed ID: 12924944
Ca(2+) signaling by TRPC3 involves Na(+) entry and local coupling to the Na(+)/Ca(2+) exchanger.
The Journal of biological chemistry Apr, 2004 | Pubmed ID: 14736881
TRPC channel interactions with calmodulin and IP3 receptors.
Novartis Foundation symposium , 2004 | Pubmed ID: 15104175
2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3.
The Journal of biological chemistry Aug, 2004 | Pubmed ID: 15194687
An alternative splicing product of the murine trpv1 gene dominant negatively modulates the activity of TRPV1 channels.
The Journal of biological chemistry Sep, 2004 | Pubmed ID: 15234965
Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion.
The Journal of cell biology Aug, 2004 | Pubmed ID: 15302852
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4.
The Journal of biological chemistry Feb, 2005 | Pubmed ID: 15590641
2-aminoethoxydiphenyl borate stimulates pulmonary C neurons via the activation of TRPV channels.
American journal of physiology. Lung cellular and molecular physiology May, 2005 | Pubmed ID: 15653710
The selectivity filter of the cation channel TRPM4.
The Journal of biological chemistry Jun, 2005 | Pubmed ID: 15845551
Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytes.
Pflügers Archiv : European journal of physiology Aug, 2005 | Pubmed ID: 15895247
Calmodulin and calcium interplay in the modulation of TRPC5 channel activity. Identification of a novel C-terminal domain for calcium/calmodulin-mediated facilitation.
The Journal of biological chemistry Sep, 2005 | Pubmed ID: 15987684
Activation of the endothelial store-operated ISOC Ca2+ channel requires interaction of protein 4.1 with TRPC4.
Circulation research Nov, 2005 | Pubmed ID: 16254212
Cellular cholesterol controls TRPC3 function: evidence from a novel dominant-negative knockdown strategy.
The Biochemical journal May, 2006 | Pubmed ID: 16448384
Thermal sensitivity of isolated vagal pulmonary sensory neurons: role of transient receptor potential vanilloid receptors.
American journal of physiology. Regulatory, integrative and comparative physiology Sep, 2006 | Pubmed ID: 16513770
TRPC3 and TRPC4 associate to form a redox-sensitive cation channel. Evidence for expression of native TRPC3-TRPC4 heteromeric channels in endothelial cells.
The Journal of biological chemistry May, 2006 | Pubmed ID: 16537542
Potentiation of TRPV3 channel function by unsaturated fatty acids.
Journal of cellular physiology Jul, 2006 | Pubmed ID: 16557504
Analogs of methyllycaconitine as novel noncompetitive inhibitors of nicotinic receptors: pharmacological characterization, computational modeling, and pharmacophore development.
Molecular pharmacology May, 2007 | Pubmed ID: 17308033
The TRPV3 mutation associated with the hairless phenotype in rodents is constitutively active.
Cell calcium Apr, 2008 | Pubmed ID: 17706768
Beta-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2007 | Pubmed ID: 17913880
Understanding the role of voltage gating of polymodal TRP channels.
The Journal of physiology Dec, 2007 | Pubmed ID: 18056113
The axon-dendrite targeting of Kv3 (Shaw) channels is determined by a targeting motif that associates with the T1 domain and ankyrin G.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2007 | Pubmed ID: 18094255
Calcium plays a central role in the sensitization of TRPV3 channel to repetitive stimulations.
The Journal of biological chemistry Mar, 2008 | Pubmed ID: 18178557
Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate.
The Journal of biological chemistry Apr, 2008 | Pubmed ID: 18230622
Sensorimotor enhancement in mouse mutants lacking the Purkinje cell-specific Gi/o modulator, Pcp2(L7).
Molecular and cellular neurosciences Jan, 2009 | Pubmed ID: 18930827
Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery.
The Journal of pharmacology and experimental therapeutics Feb, 2009 | Pubmed ID: 18984653
Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity.
Nature neuroscience Feb, 2009 | Pubmed ID: 19169252
Zinc activates damage-sensing TRPA1 ion channels.
Nature chemical biology Mar, 2009 | Pubmed ID: 19202543
NAADP mobilizes calcium from acidic organelles through two-pore channels.
Nature May, 2009 | Pubmed ID: 19387438
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
Pflügers Archiv : European journal of physiology Sep, 2009 | Pubmed ID: 19475418
Deletion of TRPC4 and TRPC6 in mice impairs smooth muscle contraction and intestinal motility in vivo.
Gastroenterology Oct, 2009 | Pubmed ID: 19549525
Potencies of cocaine methiodide on major cocaine targets in mice.
PloS one , 2009 | Pubmed ID: 19855831
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs.
Pflügers Archiv : European journal of physiology Mar, 2010 | Pubmed ID: 19888597
Calcium signaling via two-pore channels: local or global, that is the question.
American journal of physiology. Cell physiology Mar, 2010 | Pubmed ID: 20018950
TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP.
FEBS letters May, 2010 | Pubmed ID: 20159015
Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.
Current biology : CB Apr, 2010 | Pubmed ID: 20346675
Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity.
Journal of biomolecular screening Jul, 2010 | Pubmed ID: 20508255
The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.
Molecular endocrinology (Baltimore, Md.) Jul, 2010 | Pubmed ID: 20519332
Two-pore channels for integrative Ca signaling.
Communicative & integrative biology Jan, 2010 | Pubmed ID: 20539775
Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors.
The Journal of pharmacology and experimental therapeutics Sep, 2010 | Pubmed ID: 20551292
TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+.
The Journal of biological chemistry Nov, 2010 | Pubmed ID: 20720007
Agonist-activated Ca2+ influx occurs at stable plasma membrane and endoplasmic reticulum junctions.
Journal of cell science Dec, 2010 | Pubmed ID: 21062895
An emerging role for NAADP-mediated Ca2+ signaling in the pancreatic β-cell.
Islets Sep-Oct, 2010 | Pubmed ID: 21099331
Cyclic adenosine diphosphate ribose activates ryanodine receptors, whereas NAADP activates two-pore domain channels.
The Journal of biological chemistry Mar, 2011 | Pubmed ID: 21216967
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2011 | Pubmed ID: 21307247
Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes.
Molecular therapy : the journal of the American Society of Gene Therapy Oct, 2011 | Pubmed ID: 21772256
Ca2+: a versatile master key for intracellular signaling cascades.
Science China. Life sciences Aug, 2011 | Pubmed ID: 21786190
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
The Journal of biological chemistry Sep, 2011 | Pubmed ID: 21795696
TRPM8 acute desensitization is mediated by calmodulin and requires PIP(2): distinction from tachyphylaxis.
Journal of neurophysiology Dec, 2011 | Pubmed ID: 21900509
Hysteresis of gating underlines sensitization of TRPV3 channels.
The Journal of general physiology Nov, 2011 | Pubmed ID: 22006988
Heteromeric heat-sensitive TRP channels exhibit distinct temperature and chemical response.
The Journal of biological chemistry Dec, 2011 | Pubmed ID: 22184123
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