Avia Rosenhouse-Dantsker

Comparative analysis of cholesterol sensitivity of Kir channels: role of the CD loop.

Cholesterol and ion channels.

The RCK2 domain uses a coordination site present in Kir channels to confer sodium sensitivity to Slo2.2 channels.

Molecular basis of decreased Kir4.1 function in SeSAME/EAST syndrome.

Cholesterol sensitivity of KIR2.1 is controlled by a belt of residues around the cytosolic pore.

Hypercholesterolemia induces up-regulation of KACh cardiac currents via a mechanism independent of phosphatidylinositol 4,5-bisphosphate and Gβγ.

Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of Kir channels by cholesterol and PI(4,5)P2.

Regulation of ion channels by membrane lipids.

Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini.

Identification of novel cholesterol-binding regions in Kir2 channels.

Cholesterol binding to ion channels.

Silencing of Kir2 channels by caveolin-1: cross-talk with cholesterol.

Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2.

Probing binding sites and mechanisms of action of an I(Ks) activator by computations and experiments.

Cholesterol increases the open probability of cardiac KACh currents.

Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus.

Synergistic activation of G protein-gated inwardly rectifying potassium channels by cholesterol and PI(4,5)P.

Insights Into the Molecular Requirements for Cholesterol Binding to Ion Channels.

Cholesterol-Binding Sites in GIRK Channels: The Devil is in the Details.

Cholesterol intake and statin use regulate neuronal G protein-gated inwardly rectifying potassium channels.

Molecular Determinants of Cholesterol Binding to Soluble and Transmembrane Protein Domains.

Modes of Cholesterol Binding in Membrane Proteins: A Joint Analysis of 73 Crystal Structures.

Cholesterol Binding Sites in Inwardly Rectifying Potassium Channels.

Insights into the Molecular Mechanisms of Cholesterol Binding to the NPC1 and NPC2 Proteins.