Fátima Ferreira

Genetic engineering of allergens: future therapeutic products.

Gene gun bombardment with gold particles displays a particular Th2-promoting signal that over-rules the Th1-inducing effect of immunostimulatory CpG motifs in DNA vaccines.

Art v 1, the major allergen of mugwort pollen, is a modular glycoprotein with a defensin-like and a hydroxyproline-rich domain.

Molecular and immunological characterization of profilin from mugwort pollen.

IgE-mediated immediate-type hypersensitivity to the pyrazolone drug propyphenazone.

Prevention of allergen-specific IgE production and suppression of an established Th2-type response by immunization with DNA encoding hypoallergenic allergen derivatives of Bet v 1, the major birch-pollen allergen.

TH1-promoting DNA immunization against allergens modulates the ratio of IgG1/IgG2a but does not affect the anaphylactic potential of IgG1 antibodies: no evidence for the synthesis of nonanaphylactic IgG1.

Lab scale and medium scale production of recombinant allergens in Escherichia coli.

Over-expression and production of plant allergens by molecular farming strategies.

Customized antigens for desensitizing allergic patients.

Biology of weed pollen allergens.

The spectrum of allergens in ragweed and mugwort pollen.

Is genetic vaccination against allergy possible?

Modified recombinant allergens for safer immunotherapy.

Calcium-binding proteins and their role in allergic diseases.

Specific immunotherapy in pollen allergy.

Allergy multivaccines created by DNA shuffling of tree pollen allergens.

Immune recognition of novel isoforms and domains of the mugwort pollen major allergen Art v 1.

The alpha and beta subchain of Amb a 1, the major ragweed-pollen allergen show divergent reactivity at the IgE and T-cell level.

Role of the polypeptide backbone and post-translational modifications in cross-reactivity of Art v 1, the major mugwort pollen allergen.

Isoform identification and characterization of Art v 3, the lipid-transfer protein of mugwort pollen.

Development of recombinant allergens for diagnosis and therapy.

Immunize and disappear-safety-optimized mRNA vaccination with a panel of 29 allergens.

Characterization of plant food allergens: an overview on physicochemical and immunological techniques.

Antigen aggregation decides the fate of the allergic immune response.

Targeting the cysteine-stabilized fold of Art v 1 for immunotherapy of Artemisia pollen allergy.

The influence of recombinant production on the immunologic behavior of birch pollen isoallergens.

Naturally processed T cell-activating peptides of the major birch pollen allergen.

Panallergens and their impact on the allergic patient.

Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening.

Molecular metamorphosis in polcalcin allergens by EF-hand rearrangements and domain swapping.

A new allergen from ragweed (Ambrosia artemisiifolia) with homology to art v 1 from mugwort.

The role of lipid transfer proteins in allergic diseases.

Prophylactic mRNA vaccination against allergy.

Diclofenac hypersensitivity: antibody responses to the parent drug and relevant metabolites.

Production of recombinant allergens in plants.

Assessing protein immunogenicity with a dendritic cell line-derived endolysosomal degradome.

Proteomic profiling of birch (Betula verrucosa) pollen extracts from different origins.

Reshaping the Bet v 1 fold modulates T(H) polarization.

Molecular characterization of Api g 2, a novel allergenic member of the lipid-transfer protein 1 family from celery stalks.

Is aboriginal food less allergenic? Comparing IgE-reactivity of eggs from modern and ancient chicken breeds in a cohort of allergic children.

Ozone affects pollen viability and NAD(P)H oxidase release from Ambrosia artemisiifolia pollen.

Sensitization prevalence, antibody cross-reactivity and immunogenic peptide profile of Api g 2, the non-specific lipid transfer protein 1 of celery.

Expression of the major mugwort pollen allergen Art v 1 in tobacco plants and cell cultures: problems and perspectives for allergen production in plants.

Specific allergen concentration of WHO and FDA reference preparations measured using a multiple allergen standard.

Nitration of the pollen allergen bet v 1.0101 enhances the presentation of bet v 1-derived peptides by HLA-DR on human dendritic cells.

Response to Detection and analysis of unusual features in the structural model and structure-factor data of a birch pollen allergen.

Heat-induced structural changes affect OVA-antigen processing and reduce allergic response in mouse model of food allergy.

Crystallographically mapped ligand binding differs in high and low IgE binding isoforms of birch pollen allergen bet v 1.

Glutaraldehyde-Modified Recombinant Fel d 1: A Hypoallergen With Negligible Biological Activity But Retained Immunogenicity.

Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals.

Molecular and immunological characterization of ragweed (Ambrosia artemisiifolia L.) pollen after exposure of the plants to elevated ozone over a whole growing season.

Allergens of weed pollen: an overview on recombinant and natural molecules.

Allergenic relevance of nonspecific lipid transfer proteins 2: Identification and characterization of Api g 6 from celery tuber as representative of a novel IgE-binding protein family.

The fold variant BM4 is beneficial in a therapeutic Bet v 1 mouse model.

Proteomic and immunochemical characterization of glutathione transferase as a new allergen of the nematode Ascaris lumbricoides.

Stabilization of the dimeric birch pollen allergen Bet v 1 impacts its immunological properties.

Recombinant allergens for pollen immunotherapy.

Plantago lanceolata: an important trigger of summer pollinosis with limited IgE cross-reactivity.

Molecular approach to allergy diagnosis and therapy.

The impact of nitration on the structure and immunogenicity of the major birch pollen allergen Bet v 1.0101.

Glutathione-S-transferase: a minor allergen in birch pollen due to limited release from hydrated pollen.

Ligand binding modulates the structural dynamics and compactness of the major birch pollen allergen.

Correlation of sensitizing capacity and T-cell recognition within the Bet v 1 family.

Pectate lyase pollen allergens: sensitization profiles and cross-reactivity pattern.

Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen.

Elevated Toll-Like Receptor-Induced CXCL8 Secretion in Human Blood Basophils from Allergic Donors Is Independent of Toll-Like Receptor Expression Levels.

AllergenOnline: A peer-reviewed, curated allergen database to assess novel food proteins for potential cross-reactivity.

Advances in patent applications related to allergen immunotherapy.

How relevant is panallergen sensitization in the development of allergies?

Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans.

Tackling Bet v 1 and associated food allergies with a single hybrid protein.

Crystal structure of Pla l 1 reveals both structural similarity and allergenic divergence within the Ole e 1-like protein family.

T Cell Epitope-Containing Domains of Ragweed Amb a 1 and Mugwort Art v 6 Modulate Immunologic Responses in Humans and Mice.

Fusion proteins of flagellin and the major birch pollen allergen Bet v 1 show enhanced immunogenicity, reduced allergenicity, and intrinsic adjuvanticity.

Allergens of Blomia tropicalis: An Overview of Recombinant Molecules.

Expression and Characterization of Functional Recombinant Bet v 1.0101 in the Chloroplast of Chlamydomonas reinhardtii.

Identification of Proteases and Protease Inhibitors in Allergenic and Non-Allergenic Pollen.

Multi-Approach Analysis for the Identification of Proteases within Birch Pollen.

Proteomic profiling of the weed feverfew, a neglected pollen allergen source.

NMR resonance assignments of a hypoallergenic isoform of the major birch pollen allergen Bet v 1.

Conjugation of wildtype and hypoallergenic mugwort allergen Art v 1 to flagellin induces IL-10-DC and suppresses allergen-specific TH2-responses in vivo.

Two Distinct Conformations in Bet v 2 Determine Its Proteolytic Resistance to Cathepsin S.

Endolysosomal protease susceptibility of Amb a 1 as a determinant of allergenicity.

Author Correction: Conjugation of wildtype and hypoallergenic mugwort allergen Art v 1 to flagellin induces IL-10-DC and suppresses allergen-specific TH2-responses in vivo.

Context matters: T2 polarization resulting from pollen composition and not from protein-intrinsic allergenicity.

Harmonization of the Genetic Code Effectively Enhances the Recombinant Production of the Major Birch Pollen Allergen Bet v 1.

Structural basis for cross-reactivity and conformation fluctuation of the major beech pollen allergen Fag s 1.

The somatic proteins of Toxocara canis larvae and excretory-secretory products revealed by proteomics.

Artemisia pollen allergy in China: Component-resolved diagnosis reveals allergic asthma patients have significant multiple allergen sensitization.

Does clinical outcome of birch pollen immunotherapy relate to induction of blocking antibodies preventing IgE from allergen binding? A pilot study monitoring responses during first year of AIT.

Localization of Four Allergens in Artemisia Pollen by Immunofluorescent Antibodies.

Legends of Allergy and Immunology: From a curious mind to a world class scientist-A brief biography of Professor T.P. King.

Rational Design, Structure-Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants.

Multiple roles of Bet v 1 ligands in allergen stabilization and modulation of endosomal protease activity.

Similar Allergenicity to Different Species Is a Consequence of Highly Cross-Reactive Art v 1-Like Molecules.

Proteomic Analysis Reveals Allergen Variability among Breeds of the Dust Mite Blomia tropicalis.

TGFβ1 mimetic peptide modulates immune response to grass pollen allergens in mice.

N-terminal peptide deletion influences immunological and structural features of Blo t 5.

Defining biomarkers to predict symptoms in subjects with and without allergy under natural pollen exposure.

A hybrid of two major Blomia tropicalis allergens as an allergy vaccine candidate.