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A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory.
Science translational medicine Nov, 2014 | Pubmed ID: 25378645
Mucosal delivery of a vectored RSV vaccine is safe and elicits protective immunity in rodents and nonhuman primates.
Molecular therapy. Methods & clinical development , 2015 | Pubmed ID: 26015988
Chimpanzee adenovirus- and MVA-vectored respiratory syncytial virus vaccine is safe and immunogenic in adults.
Science translational medicine Aug, 2015 | Pubmed ID: 26268313
Efficacy of a virus-vectored vaccine against human and bovine respiratory syncytial virus infections.
Science translational medicine Aug, 2015 | Pubmed ID: 26268314
Chronic hepatitis C viral infection subverts vaccine-induced T-cell immunity in humans.
Hepatology (Baltimore, Md.) May, 2016 | Pubmed ID: 26474390
Antibody response to respiratory syncytial virus infection in children <18 months old.
Human vaccines & immunotherapeutics 07, 2016 | Pubmed ID: 26901128
Highly-Immunogenic Virally-Vectored T-cell Vaccines Cannot Overcome Subversion of the T-cell Response by HCV during Chronic Infection.
Vaccines Aug, 2016 | Pubmed ID: 27490575
Induction and Maintenance of CX3CR1-Intermediate Peripheral Memory CD8 T Cells by Persistent Viruses and Vaccines.
Cell reports Apr, 2018 | Pubmed ID: 29669283
Safety and Immunogenicity of a Heterologous Prime-Boost Ebola Virus Vaccine Regimen in Healthy Adults in the United Kingdom and Senegal.
The Journal of infectious diseases 04, 2019 | Pubmed ID: 30407513
Novel genetically-modified chimpanzee adenovirus and MVA-vectored respiratory syncytial virus vaccine safely boosts humoral and cellular immunity in healthy older adults.
The Journal of infection 05, 2019 | Pubmed ID: 30742894
Characterizing Hepatitis C Virus-Specific CD4 T Cells Following Viral-Vectored Vaccination, Directly Acting Antivirals, and Spontaneous Viral Cure.
Hepatology (Baltimore, Md.) Nov, 2020 | Pubmed ID: 32012325
A next generation vaccine against human rabies based on a single dose of a chimpanzee adenovirus vector serotype C.
PLoS neglected tropical diseases 07, 2020 | Pubmed ID: 32667913
Optimising T cell (re)boosting strategies for adenoviral and modified vaccinia Ankara vaccine regimens in humans.
NPJ vaccines , 2020 | Pubmed ID: 33083029
Innate Immune Responses to Chimpanzee Adenovirus Vector 155 Vaccination in Mice and Monkeys.
Frontiers in immunology , 2020 | Pubmed ID: 33329551
Sonia Simonetti*,1,2,
Ambra Natalini*,1,2,
Giovanna Peruzzi3,
Alfredo Nicosia4,
Antonella Folgori5,
Stefania Capone5,
Angela Santoni2,6,
Francesca Di Rosa1
1Institute of Molecular Biology and Pathology, National Research Council of Italy (CNR),
2Department of Molecular Medicine, University of Rome “Sapienza”,
3Center for Life Nano Science, Istituto Italiano di Tecnologia,
4Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II,
5, Reithera Srl,
6, IRCCS, Neuromed
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