Oliver Schilling

Proteome Profiling of Primary Pancreatic Ductal Adenocarcinomas Undergoing Additive Chemoradiation Link ALDH1A1 to Early Local Recurrence and Chemoradiation Resistance.

Characterization of the prime and non-prime active site specificities of proteases by proteome-derived peptide libraries and tandem mass spectrometry.

Protease specificity profiling by tandem mass spectrometry using proteome-derived peptide libraries.

Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo.

Proteomic analyses reveal an acidic prime side specificity for the astacin metalloprotease family reflected by physiological substrates.

Factor Xa subsite mapping by proteome-derived peptide libraries improved using WebPICS, a resource for proteomic identification of cleavage sites.

Identification and relative quantification of native and proteolytically generated protein C-termini from complex proteomes: C-terminome analysis.

Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S.

Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts.

NSP4, an elastase-related protease in human neutrophils with arginine specificity.

Enhanced identification of peptides lacking basic residues by LC-ESI-MS/MS analysis of singly charged peptides.

Glycocapture-based proteomics for secretome analysis.

Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome.

Global remodelling of cellular microenvironment due to loss of collagen VII.

Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis.

Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells.

Transmembrane collagen XVII modulates integrin dependent keratinocyte migration via PI3K/Rac1 signaling.

Prognostic significance of Zinc finger E-box binding homeobox 1 (ZEB1) expression in cancer cells and cancer-associated fibroblasts in pancreatic head cancer.

Automated peptide mapping and protein-topographical annotation of proteomics data.

Carboxyterminal protein processing in health and disease: key actors and emerging technologies.

Septins arrange F-actin-containing fibers on the Chlamydia trachomatis inclusion and are required for normal release of the inclusion by extrusion.

Protein amino-terminal modifications and proteomic approaches for N-terminal profiling.

The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells.

Toward improved peptide feature detection in quantitative proteomics using stable isotope labeling.

Enrichment of protein N-termini by charge reversal of internal peptides.

miR-200c dampens cancer cell migration via regulation of protein kinase A subunits.

The stromal cell-surface protease fibroblast activation protein-α localizes to lipid rafts and is recruited to invadopodia.

Quantitative proteomic analysis of formalin-fixed, paraffin-embedded clear cell renal cell carcinoma tissue using stable isotopic dimethylation of primary amines.

Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations.

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses.

An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation.

Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers.

A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity.

Mesopancreatic Stromal Clearance Defines Curative Resection of Pancreatic Head Cancer and Can Be Predicted Preoperatively by Radiologic Parameters: A Retrospective Study.

Characterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses.

Formalin-Fixed, Paraffin-Embedded Tissues (FFPE) as a Robust Source for the Profiling of Native and Protease-Generated Protein Amino Termini.

Skin Barrier Defects Caused by Keratinocyte-Specific Deletion of ADAM17 or EGFR Are Based on Highly Similar Proteome and Degradome Alterations.

Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics.

The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity.

Cathepsin A inhibition attenuates myocardial infarction-induced heart failure on the functional and proteomic levels.

Comprehensive Proteomic Analysis of Nitrogen-Starved Mycobacterium smegmatis Δpup Reveals the Impact of Pupylation on Nitrogen Stress Response.

Yeast membrane proteomics using leucine metabolic labelling: Bioinformatic data processing and exemplary application to the ER-intramembrane protease Ypf1.

Proteomic Profiling of Cardiomyocyte-Specific Cathepsin A Overexpression Links Cathepsin A to the Oxidative Stress Response.

Determinants of Macromolecular Specificity from Proteomics-Derived Peptide Substrate Data.

Proteomic analysis of silenced cathepsin B expression suggests non-proteolytic cathepsin B functionality.

OpenMS: a flexible open-source software platform for mass spectrometry data analysis.

Pregnancy Specific β-1 Glycoprotein 1 is Expressed in Pancreatic Ductal Adenocarcinoma and its Subcellular Localization Correlates with Overall Survival.

Tenascin-C Orchestrates Glioblastoma Angiogenesis by Modulation of Pro- and Anti-angiogenic Signaling.

The papain-like cysteine proteinases NbCysP6 and NbCysP7 are highly processive enzymes with substrate specificities complementary to Nicotiana benthamiana cathepsin B.

Identification of Protease Cleavage Sites by Charge-Based Enrichment of Protein N-Termini.

System-Wide Profiling of Protein Amino Termini from Formalin-Fixed, Paraffin-Embedded Tissue Specimens for the Identification of Novel Substrates.

Profiling of Protease Cleavage Sites by Proteome-Derived Peptide Libraries and Quantitative Proteomics.

Proteomics highlights decrease of matricellular proteins in left ventricular assist device therapy†.

The Prognostic Impact of the Carcinoembryonic Antigen in Ampullary Cancer - A Retrospective Single Center Study.

Form follows function: Morphological and immunohistological insights into epithelial-mesenchymal transition characteristics of tumor buds.

Differential effect of TGFβ on the proteome of cancer associated fibroblasts and cancer epithelial cells in a co-culture approach - a short report.

HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.

Identification of tissue damage, extracellular matrix remodeling and bacterial challenge as common mechanisms associated with high-risk cutaneous squamous cell carcinomas.

Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression.

Proteome profiling of clear cell renal cell carcinoma in von Hippel-Lindau patients highlights upregulation of Xaa-Pro aminopeptidase-1, an anti-proliferative and anti-migratory exoprotease.

Proteomic Characterization of Prostate Cancer to Distinguish Nonmetastasizing and Metastasizing Primary Tumors and Lymph Node Metastases.

HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.

Reproducible proteomics sample preparation for single FFPE tissue slices using acid-labile surfactant and direct trypsinization.

The pleiotropic roles of ADAM9 in the biology of solid tumors.

N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration.

Morphology of Immunomodulation in Breast Cancer Tumor Draining Lymph Nodes Depends on Stage and Intrinsic Subtype.

Specificity profiling of human trypsin-isoenzymes.

The two cathepsin B-like proteases of Arabidopsis thaliana are closely related enzymes with discrete endopeptidase and carboxydipeptidase activities.

Nanoparticle decoration impacts airborne fungal pathobiology.

Structural determinants of specificity and regulation of activity in the allosteric loop network of human KLK8/neuropsin.

Proteomic distinction of renal oncocytomas and chromophobe renal cell carcinomas.

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics.

Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer.

Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics.

Infection of HeLa cells with Chlamydia trachomatis inhibits protein synthesis and causes multiple changes to host cell pathways.

ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma.

Detection and Characterization of a Mycobacterial L-Arabinofuranose ABC Transporter Identified with a Rapid Lipoproteomics Protocol.

Radiomic features from PSMA PET for non-invasive intraprostatic tumor discrimination and characterization in patients with intermediate- and high-risk prostate cancer - a comparison study with histology reference.

Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome.

A human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins.

Impact of left ventricular assist device therapy on the cardiac proteome and metabolome composition in ischemic cardiomyopathy.

Neuronal-specific microexon splicing of mRNA is directly regulated by SRRM4/nSR100.

Targeted Metabolic Profiling of Methionine Cycle Metabolites and Redox Thiol Pools in Mammalian Plasma, Cells and Urine.

Accessible and reproducible mass spectrometry imaging data analysis in Galaxy.

Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death.

The secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases.

FOLFIRINOX Gemcitabine-based Therapy for Pancreatic Ductal Adenocarcinoma: Lessons from Patient-derived Cell Lines.

Deep multiple instance learning classifies subtissue locations in mass spectrometry images from tissue-level annotations.

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice.

Neoplastic-Stromal Cell Cross-talk Regulates Matrisome Expression in Pancreatic Cancer.

Corrigendum to "Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics" [Biomaterials 192 (2019) 551-559].

Multimodal imaging for radiation therapy planning in patients with primary prostate cancer.

Discovery of a small protein factor involved in the coordinated degradation of phycobilisomes in cyanobacteria.

SRGAP1 Controls Small Rho GTPases To Regulate Podocyte Foot Process Maintenance.

Origin and Expansion of the Serine Protease Repertoire in the Myelomonocyte Lineage.

Role of Kallikrein 7 in Body Weight and Fat Mass Regulation.

Impact of DJ-1 and Helix 8 on the Proteome and Degradome of Neuron-Like Cells.

First report on establishment and characterization of a carcinosarcoma tumour cell line model of the bladder.

A Systematic Evaluation of Semispecific Peptide Search Parameter Enables Identification of Previously Undescribed N-Terminal Peptides and Conserved Proteolytic Processing in Cancer Cell Lines.