Christoph Handschin

A Link between cholesterol levels and phenobarbital induction of cytochromes P450.

NUBIScan, an in silico approach for prediction of nuclear receptor response elements.

Cholesterol and bile acids regulate xenosensor signaling in drug-mediated induction of cytochromes P450.

An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle.

Induction of drug metabolism: the role of nuclear receptors.

In silico approaches, and in vitro and in vivo experiments to predict induction of drug metabolism.

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK.

Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle.

Identification of the xenosensors regulating human 5-aminolevulinate synthase.

The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals.

Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.

Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.

Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.

LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver.

Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.

Metabolic control through the PGC-1 family of transcription coactivators.

Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha.

Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism.

Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.

PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription.

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.

RANTES (regulated on activation, normal T cell expressed and secreted), inflammation, obesity, and the metabolic syndrome.

PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy.

A fundamental system of cellular energy homeostasis regulated by PGC-1alpha.

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.

Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals.

Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk.

The role of exercise and PGC1alpha in inflammation and chronic disease.

A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells.

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.

The biology of PGC-1α and its therapeutic potential.

Peroxisome proliferator-activated receptor-gamma coactivator-1alpha in muscle links metabolism to inflammation.

For a pragmatic approach to exercise studies.

PGC-1α and myokines in the aging muscle - a mini-review.

Regulation of skeletal muscle cell plasticity by the peroxisome proliferator-activated receptor γ coactivator 1α.

Electric pulse stimulation of cultured murine muscle cells reproduces gene expression changes of trained mouse muscle.

SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice.

Peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} (PGC-1{alpha}) promotes skeletal muscle lipid refueling in vivo by activating de novo lipogenesis and the pentose phosphate pathway.

ApoE-/- PGC-1α-/- mice display reduced IL-18 levels and do not develop enhanced atherosclerosis.

PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination.

Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity.

Remodeling of calcium handling in skeletal muscle through PGC-1α: impact on force, fatigability, and fiber type.

Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function.

PGC-1α determines light damage susceptibility of the murine retina.