David T. Scadden

Matrix metalloproteinase inhibitor COL-3 in the treatment of AIDS-related Kaposi's sarcoma: a phase I AIDS malignancy consortium study.

Human HTm4 is a hematopoietic cell cycle regulator.

Antitumor activity of oral 9-cis-retinoic acid in HIV-associated Kaposi's sarcoma.

Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome.

Receptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cells.

Thymocyte emigration is mediated by active movement away from stroma-derived factors.

A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy.

Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma.

Cell cycle entry of hematopoietic stem and progenitor cells controlled by distinct cyclin-dependent kinase inhibitors.

Multicenter trial of low-dose paclitaxel in patients with advanced AIDS-related Kaposi sarcoma.

The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1).

Heterologous cells cooperate to augment stem cell migration, homing, and engraftment.

Toward cellular-based therapies for HIV infection.

The contribution of cytotoxic and noncytotoxic function by donor T-cells that support engraftment after allogeneic bone marrow transplantation.

Multiple measures of HIV burden in blood and tissue are correlated with each other but not with clinical parameters in aviremic subjects.

Lack of antitumor activity and intolerance of interleukin-4 in patients with advanced HIV disease and Kaposi's sarcoma.

AIDS-related malignancies.

Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cells.

Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter.

P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells.

Immune reconstitution in HIV infection and its relationship to cancer.

Ephrin receptor, EphB4, regulates ES cell differentiation of primitive mammalian hemangioblasts, blood, cardiomyocytes, and blood vessels.

Stem cells and immune reconstitution in AIDS.

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.

The malignant side of successful transplantation.

P21cip1/waf1 受限制的缺血性脑的再生反应。

In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C.

Direct vascular delivery of primitive hematopoietic cells to bone marrow improves localization but not engraftment.

Cancer stem cells refined.

Flowing cells through pulsed electric fields efficiently purges stem cell preparations of contaminating myeloma cells while preserving stem cell function.

Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles.

Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AIDS Malignancy Consortium and IM862 Study Team.

Anemia in HIV-infected adults: epidemiology, pathogenesis, and clinical management.

Generic antiretroviral efficacy in AIDS-associated Kaposi's sarcoma in sub-Saharan Africa.

Kinetic expression of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) during embryonic stem cell differentiation.

Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis.

Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.

Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium Trial 010.

Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size.

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment.

Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells.

Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins.

Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood.

Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population.

Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection.

HOXB4-induced self-renewal of hematopoietic stem cells is significantly enhanced by p21 deficiency.

Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients.

Plasmablastic lymphoma in HIV-positive patients: an aggressive Epstein-Barr virus-associated extramedullary plasmacytic neoplasm.

Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors.

Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor.

CXCR4 and CCR5 mediate homing of primitive bone marrow-derived hematopoietic cells to the postnatal thymus.

Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antiangiogenic therapy.

The hematopoietic stem cell in its place.

Stem cells: good, bad and reformable.

Osteoclasts eat stem cells out of house and home.

The stem-cell niche as an entity of action.

Embryonic stem cells make human T cells.

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.

Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes.

Case records of the Massachusetts General Hospital. Case 30-2006. A 41-year-old man with dyspnea, fever, and lymphadenopathy.

Stromal cell-derived factor-1/CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro.

AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.

Therapeutic targeting of a stem cell niche.

Primitive hematopoietic cells resist HIV-1 infection via p21.

Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.

Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory phenotypes.

The stem cell niche in health and leukemic disease.

A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood.

Kaposi's sarcoma-associated herpesvirus-specific immune reconstitution and antiviral effect of combined HAART/chemotherapy in HIV clade C-infected individuals with Kaposi's sarcoma.

A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency.

Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels.

The weight of cell identity.

Dose-reduced busulfan, cyclophosphamide, and autologous stem cell transplantation for human immunodeficiency virus-associated lymphoma: AIDS Malignancy Consortium study 020.

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation.

Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice.

Functional analyses of the cancer stem cell-like properties of human endometrial tumor initiating cells.

Prospects for stem cell-based therapy.

Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias.

Circadian rhythms: stem cells traffic in time.

Stem cells remember their grade.

Limiting factors in murine hematopoietic stem cell assays.

Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.

Stem-cell ecology and stem cells in motion.

Differentiation and characterization of T cells.

Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation.

Differential H3K4 methylation identifies developmentally poised hematopoietic genes.

Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3.

Evolving concepts on the microenvironmental niche for hematopoietic stem cells.

MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors.

Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture.

Analysis of the hematopoietic stem cell niche.

GATA-2 regulates granulocyte-macrophage progenitor cell function.

Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways.

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche.

Divided within: heterogeneity within adult stem cell pools.

Will stem cells finally deliver?

Forward RNAi screens in primary human hematopoietic stem/progenitor cells.

Role of the osteoblast lineage in the bone marrow hematopoietic niches.

Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow.

p27Kip1 constrains proliferation of neural progenitor cells in adult brain under homeostatic and ischemic conditions.

The leukemic stem cell niche: current concepts and therapeutic opportunities.

VEGFR2+PDGFRbeta+ circulating precursor cells participate in capillary restoration after hyperoxia acute lung injury (HALI).

CD133 expression defines a tumor initiating cell population in primary human ovarian cancer.

Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.

The HSC niche concept has turned 31. Has our knowledge matured?

MicroRNA miR-125a controls hematopoietic stem cell number.

Vitamin D receptor deletion leads to increased hematopoietic stem and progenitor cells residing in the spleen.

Stem cells and DNA damage: persist or perish?

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche.

A microRNA regulating adult hematopoietic stem cells.

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival.

In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow.

Biomimetic platforms for human stem cell research.

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation.

Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells.

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification.

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche.

Differential niche and Wnt requirements during acute myeloid leukemia progression.

AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias.

Diabetes impairs hematopoietic stem cell mobilization by altering niche function.

NF-Y is necessary for hematopoietic stem cell proliferation and survival.

The haematopoietic stem cell niche at a glance.

The bone marrow at the crossroads of blood and immunity.

The hematopoietic stem cell niche.

Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration.

A randomized controlled trial of highly active antiretroviral therapy versus highly active antiretroviral therapy and chemotherapy in therapy-naive patients with HIV-associated Kaposi sarcoma in South Africa.

Deconstructing the complexity of a microenvironmental niche.

The secrets of the bone marrow niche: Metabolic priming for AML.

Rethinking stroma: lessons from the blood.

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis.

The stem cell niche: tissue physiology at a single cell level.

mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.

Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms.

Fate through fat: lipid metabolism determines stem cell division outcome.

Advances in the biology and therapy of chronic myeloid leukemia: proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Workshop.

Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling.

The hematopoietic stem cell niche--home for friend and foe?

SIRT3 reverses aging-associated degeneration.

Xist RNA is a potent suppressor of hematologic cancer in mice.

BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression.

Differential stem- and progenitor-cell trafficking by prostaglandin E2.

Influenza, but not HIV-specific CTL epitopes, elicits delayed-type hypersensitivity (DTH) reactions in HIV-infected patients.

In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling.

Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells.

Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label.

Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation.

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells.

Differential regulation of myeloid leukemias by the bone marrow microenvironment.

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia.

Modeling human hematopoietic stem cell biology in the mouse.

Correction: Tracking Single Cells in Live Animals Using a Photoconvertible Near-Infrared Cell Membrane Label.

Blood scent.

Genome-wide map of nuclear protein degradation shows NCoR1 turnover as a key to mitochondrial gene regulation.

The bone marrow niche for haematopoietic stem cells.

Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89.

Bone's dark side: mutated osteoblasts implicated in leukemia.

Direct measurement of local oxygen concentration in the bone marrow of live animals.

Nice neighborhood: emerging concepts of the stem cell niche.

Tic-TACs: Refreshing Hair Growth.

Bayesian approach to single-cell differential expression analysis.

Mesenchymal Cell Contributions to the Stem Cell Niche.

Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention.

Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow.

Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells.

Harnessing the apoptotic programs in cancer stem-like cells.

Engineering pulmonary vasculature in decellularized rat and human lungs.

Global transcriptome analysis of T-competent progenitors in the bone marrow.

Transcriptome comparison of distinct osteolineage subsets in the hematopoietic stem cell niche using a triple fluorescent transgenic mouse model.

A hostel for the hostile: the bone marrow niche in hematologic neoplasms.

Not All Created Equal: Lineage Hard-Wiring in the Production of Blood.

Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway.

Distinct bone marrow blood vessels differentially regulate haematopoiesis.

Hematopoietic Stem Cell and Its Bone Marrow Niche.

Blood and Bone.

Heterogeneity of the bone marrow niche.

Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse.

Hematopoietic Stem Cell Niche in Health and Disease.

Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin.

Targeting the Warburg effect for leukemia therapy: Magnitude matters.

Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow.

Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells.

Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators.

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment.

Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells.

Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease.

Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.

Shipping mouse bone marrow: Keep it in the bone.

Hematopoiesis: Reconciling Historic Controversies about the Niche.

ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells.

The metabolic regulator mTORC1 controls terminal myeloid differentiation.

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF neutrophils.

Bone marrow drives central nervous system regeneration after radiation injury.

Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell.

deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm.

The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model.

dropEst: pipeline for accurate estimation of molecular counts in droplet-based single-cell RNA-seq experiments.

Modulating Bone Marrow Hematopoietic Lineage Potential to Prevent Bone Metastasis in Breast Cancer.

Cell Cycle Analysis of Hematopoietic Stem and Progenitor Cells by Multicolor Flow Cytometry.

Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation.

An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation.

Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke.

Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.

The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.

Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress.

A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia.

Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping.

Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells.

Metcalf Lecture Award: Applying niche biology to engineer T-cell regenerative therapies.

A biomaterial-based vaccine eliciting durable tumour-specific responses against acute myeloid leukaemia.

Lipid availability determines fate of skeletal progenitor cells via SOX9.

Efficacy and safety of anti-CD45-saporin as conditioning agent for RAG deficiency.

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.

C9orf72 suppresses systemic and neural inflammation induced by gut bacteria.

Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance.

Adult blood stem cell localization reflects the abundance of reported bone marrow niche cell types and their combinations.

Cell interactions in the bone marrow microenvironment affecting myeloid malignancies.

Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress.

Progression signature underlies clonal evolution and dissemination of multiple myeloma.

Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML.

Young haematopoietic stem cells are picky eaters.

Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.

Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics.

In memory of Paul Sylvain Frenette, a pioneering explorer of the hematopoietic stem cell niche who left far too early.

tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche.

Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth.

Author Correction: An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation.

Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment.

Analysis of Leukemia Cell Metabolism through Stable Isotope Tracing in Mice.

Chromatin-state barriers enforce an irreversible mammalian cell fate decision.

Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation.

What is the role of the bone marrow microenvironment in AML?

B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis.

Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis.

Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease.

In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies.

Recent advances in "sickle and niche" research - Tribute to Dr. Paul S Frenette.

Sleep exerts lasting effects on hematopoietic stem cell function and diversity.

A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma.

Isolation of Thymus Stromal Cells from Human and Murine Tissue.

Defocus Corrected Large Area Cryo-EM (DeCo-LACE) for label-free detection of molecules across entire cell sections.

Image-seq: spatially resolved single-cell sequencing guided by in situ and in vivo imaging.

Immune-responsive biodegradable scaffolds for enhancing neutrophil regeneration.

Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses.

Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors.

The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression.

Health Consequences of Thymus Removal in Adults.

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.

Adult Prg4+ progenitors repair long-term articular cartilage wounds in vivo.

Clearing and replacing tissue-resident myeloid cells with an anti-CD45 antibody-drug conjugate.

Health Consequences of Thymus Removal in Adults. Reply.