David T. Scadden

Center for Regenerative Medicine, MGH - Massachusetts General Hospital

Affiliated withMGH - Massachusetts General Hospital Harvard Stem Cell Institute Massachusetts General Hospital

Research Area

BiologyMedicineImmunology and Infection

Biography

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JoVE Journal Publications

Article Total : 3	Year
Publication title	2009
Publication title	2014
Publication title	2024

Other Publications

Article	Year
Matrix metalloproteinase inhibitor COL-3 in the treatment of AIDS-related Kaposi's sarcoma: a phase I AIDS malignancy consortium study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 11773164	2002
Human HTm4 is a hematopoietic cell cycle regulator. The Journal of clinical investigation\| PubMed ID: 11781350	2002
Antitumor activity of oral 9-cis-retinoic acid in HIV-associated Kaposi's sarcoma. AIDS (London, England)\| PubMed ID: 11834954	2002
Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood\| PubMed ID: 11895769	2002
Receptor tyrosine kinase, EphB4 (HTK), accelerates differentiation of select human hematopoietic cells. Blood\| PubMed ID: 11929761	2002
Thymocyte emigration is mediated by active movement away from stroma-derived factors. The Journal of clinical investigation\| PubMed ID: 11956248	2002
A phase II randomized study of HIV-specific T-cell gene therapy in subjects with undetectable plasma viremia on combination antiretroviral therapy. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 12027564	2002
Absence of biologically important Kaposi sarcoma-associated herpesvirus gene products and virus-specific cellular immune responses in multiple myeloma. Blood\| PubMed ID: 12091368	2002
Cell cycle entry of hematopoietic stem and progenitor cells controlled by distinct cyclin-dependent kinase inhibitors. International journal of hematology\| PubMed ID: 12095144	2002
Multicenter trial of low-dose paclitaxel in patients with advanced AIDS-related Kaposi sarcoma. Cancer\| PubMed ID: 12115328	2002
The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1). AIDS (London, England)\| PubMed ID: 12218384	2002
Heterologous cells cooperate to augment stem cell migration, homing, and engraftment. Blood\| PubMed ID: 12393569	2003
Toward cellular-based therapies for HIV infection. Journal of hematotherapy & stem cell research\| PubMed ID: 12427282	2002
The contribution of cytotoxic and noncytotoxic function by donor T-cells that support engraftment after allogeneic bone marrow transplantation. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 12463477	2002
Multiple measures of HIV burden in blood and tissue are correlated with each other but not with clinical parameters in aviremic subjects. AIDS (London, England)\| PubMed ID: 12478069	2003
Lack of antitumor activity and intolerance of interleukin-4 in patients with advanced HIV disease and Kaposi's sarcoma. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research\| PubMed ID: 12513914	2002
AIDS-related malignancies. Annual review of medicine\| PubMed ID: 12525676	2003
Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cells. Blood\| PubMed ID: 12702511	2003
Myeloid expression of cytochrome P450 4F3 is determined by a lineage-specific alternative promoter. The Journal of biological chemistry\| PubMed ID: 12709424	2003
P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells. Genes & development\| PubMed ID: 12842911	2003
Immune reconstitution in HIV infection and its relationship to cancer. Hematology/oncology clinics of North America\| PubMed ID: 12852652	2003
Ephrin receptor, EphB4, regulates ES cell differentiation of primitive mammalian hemangioblasts, blood, cardiomyocytes, and blood vessels. Blood\| PubMed ID: 12958066	2004
Stem cells and immune reconstitution in AIDS. Blood reviews\| PubMed ID: 14556777	2003
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nature medicine\| PubMed ID: 14745444	2004
The malignant side of successful transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons\| PubMed ID: 14974933	2004
P21cip1/waf1 受限制的缺血性脑的再生反应。 The Journal of experimental medicine\| PubMed ID: 15067031	2004
In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C. Nature cell biology\| PubMed ID: 15122268	2004
Direct vascular delivery of primitive hematopoietic cells to bone marrow improves localization but not engraftment. Blood\| PubMed ID: 15178586	2004
Cancer stem cells refined. Nature immunology\| PubMed ID: 15224098	2004
Flowing cells through pulsed electric fields efficiently purges stem cell preparations of contaminating myeloma cells while preserving stem cell function. Blood\| PubMed ID: 15292069	2005
Defective immune function of primary effusion lymphoma cells is associated with distinct KSHV gene expression profiles. Leukemia & lymphoma\| PubMed ID: 15360006	2004
Angiogenesis inhibitor IM862 is ineffective against AIDS-Kaposi's sarcoma in a phase III trial, but demonstrates sustained, potent effect of highly active antiretroviral therapy: from the AI... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 15598977	2005
Anemia in HIV-infected adults: epidemiology, pathogenesis, and clinical management. Current hematology reports\| PubMed ID: 15720957	2005
Generic antiretroviral efficacy in AIDS-associated Kaposi's sarcoma in sub-Saharan Africa. AIDS (London, England)\| PubMed ID: 15750399	2005
Kinetic expression of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) during embryonic stem cell differentiation. Journal of cellular biochemistry\| PubMed ID: 15786495	2005
Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood\| PubMed ID: 15811962	2005
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nature medicine\| PubMed ID: 15880117	2005
Rituximab does not improve clinical outcome in a randomized phase 3 trial of CHOP with or without rituximab in patients with HIV-associated non-Hodgkin lymphoma: AIDS-Malignancies Consortium... Blood\| PubMed ID: 15914552	2005
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. The Journal of experimental medicine\| PubMed ID: 15928197	2005
In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment. Nature\| PubMed ID: 15959517	2005
Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. The Journal of clinical investigation\| PubMed ID: 16007251	2005
Impact of Kaposi sarcoma-associated herpesvirus (KSHV) burden and HIV coinfection on the detection of T cell responses to KSHV ORF73 and ORF65 proteins. The Journal of infectious diseases\| PubMed ID: 16028131	2005
Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. Cell\| PubMed ID: 16051153	2005
Alpha E beta 7 (CD103) expression identifies a highly active, tonsil-resident effector-memory CTL population. Journal of immunology (Baltimore, Md. : 1950)\| PubMed ID: 16177076	2005
Differential targeting and shifts in the immunodominance of Epstein-Barr virus--specific CD8 and CD4 T cell responses during acute and persistent infection. The Journal of infectious diseases\| PubMed ID: 16206065	2005
HOXB4-induced self-renewal of hematopoietic stem cells is significantly enhanced by p21 deficiency. Stem cells (Dayton, Ohio)\| PubMed ID: 16210402	2006
Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 16258121	2005
Plasmablastic lymphoma in HIV-positive patients: an aggressive Epstein-Barr virus-associated extramedullary plasmacytic neoplasm. The American journal of surgical pathology\| PubMed ID: 16327436	2005
Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors. Blood\| PubMed ID: 16339405	2006
Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature\| PubMed ID: 16382241	2006
CXCR4 and CCR5 mediate homing of primitive bone marrow-derived hematopoietic cells to the postnatal thymus. Experimental hematology\| PubMed ID: 16543065	2006
Differential CD146 expression on circulating versus tissue endothelial cells in rectal cancer patients: implications for circulating endothelial and progenitor cells as biomarkers for antian... Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 16549839	2006
The hematopoietic stem cell in its place. Nature immunology\| PubMed ID: 16550195	2006
Stem cells: good, bad and reformable. Nature\| PubMed ID: 16724049	2006
Osteoclasts eat stem cells out of house and home. Nature medicine\| PubMed ID: 16761001	2006
The stem-cell niche as an entity of action. Nature\| PubMed ID: 16810242	2006
Embryonic stem cells make human T cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 16894150	2006
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature\| PubMed ID: 16957735	2006
Tumor stromal-derived factor-1 recruits vascular progenitors to mitotic neovasculature, where microenvironment influences their differentiated phenotypes. Cancer research\| PubMed ID: 16982747	2006
Case records of the Massachusetts General Hospital. Case 30-2006. A 41-year-old man with dyspnea, fever, and lymphadenopathy. The New England journal of medicine\| PubMed ID: 17005954	2006
Stromal cell-derived factor-1/CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro. Stem cells (Dayton, Ohio)\| PubMed ID: 17038674	2007
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer cell\| PubMed ID: 17222792	2007
Therapeutic targeting of a stem cell niche. Nature biotechnology\| PubMed ID: 17237769	2007
Primitive hematopoietic cells resist HIV-1 infection via p21. The Journal of clinical investigation\| PubMed ID: 17273559	2007
Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo. Nature biotechnology\| PubMed ID: 17322871	2007
Lytic and latent antigens of the human gammaherpesviruses Kaposi's sarcoma-associated herpesvirus and Epstein-Barr virus induce T-cell responses with similar functional properties and memory... Journal of virology\| PubMed ID: 17329344	2007
The stem cell niche in health and leukemic disease. Best practice & research. Clinical haematology\| PubMed ID: 17336251	2007
A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood. Nature protocols\| PubMed ID: 17446880	2007
Kaposi's sarcoma-associated herpesvirus-specific immune reconstitution and antiviral effect of combined HAART/chemotherapy in HIV clade C-infected individuals with Kaposi's sarcoma. AIDS (London, England)\| PubMed ID: 17545700	2007
A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell\| PubMed ID: 17574023	2007
Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels. Blood\| PubMed ID: 17993613	2008
The weight of cell identity. The Journal of clinical investigation\| PubMed ID: 18060026	2007
Dose-reduced busulfan, cyclophosphamide, and autologous stem cell transplantation for human immunodeficiency virus-associated lymphoma: AIDS Malignancy Consortium study 020. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation\| PubMed ID: 18158962	2008
Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nature reviews. Genetics\| PubMed ID: 18202695	2008
Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. The Journal of clinical investigation\| PubMed ID: 18219387	2008
Functional analyses of the cancer stem cell-like properties of human endometrial tumor initiating cells. Cell cycle (Georgetown, Tex.)\| PubMed ID: 18256549	2008
Prospects for stem cell-based therapy. Cell\| PubMed ID: 18295571	2008
Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias. Blood\| PubMed ID: 18299447	2008
Circadian rhythms: stem cells traffic in time. Nature\| PubMed ID: 18368105	2008
Stem cells remember their grade. Cell stem cell\| PubMed ID: 18371344	2007
Limiting factors in murine hematopoietic stem cell assays. Cell stem cell\| PubMed ID: 18371361	2007
Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo. Cell stem cell\| PubMed ID: 18371452	2008
Stem-cell ecology and stem cells in motion. Blood\| PubMed ID: 18398055	2008
Differentiation and characterization of T cells. Current protocols in immunology / edited by John E. Coligan ... [et al.]\| PubMed ID: 18432955	2005
Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation. Experimental hematology\| PubMed ID: 18439488	2008
Differential H3K4 methylation identifies developmentally poised hematopoietic genes. Developmental cell\| PubMed ID: 18477461	2008
Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3. Cell stem cell\| PubMed ID: 18522851	2008
Evolving concepts on the microenvironmental niche for hematopoietic stem cells. Current opinion in hematology\| PubMed ID: 18536566	2008
MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Developmental cell\| PubMed ID: 18539114	2008
Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture. Cell stem cell\| PubMed ID: 18682243	2008
Analysis of the hematopoietic stem cell niche. Current protocols in stem cell biology\| PubMed ID: 18785177	2007
GATA-2 regulates granulocyte-macrophage progenitor cell function. Blood\| PubMed ID: 18840712	2008
Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 18957542	2008
Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche. Nature\| PubMed ID: 19052546	2009
Divided within: heterogeneity within adult stem cell pools. Cell\| PubMed ID: 19070570	2008
Will stem cells finally deliver? Newsweek\| PubMed ID: 19105310	2008
Forward RNAi screens in primary human hematopoietic stem/progenitor cells. Blood\| PubMed ID: 19188664	2009
Role of the osteoblast lineage in the bone marrow hematopoietic niches. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 19257832	2009
Haematopoietic stem cells depend on Galpha(s)-mediated signalling to engraft bone marrow. Nature\| PubMed ID: 19322176	2009
p27Kip1 constrains proliferation of neural progenitor cells in adult brain under homeostatic and ischemic conditions. Stem cells (Dayton, Ohio)\| PubMed ID: 19353520	2009
The leukemic stem cell niche: current concepts and therapeutic opportunities. Blood\| PubMed ID: 19401558	2009
VEGFR2+PDGFRbeta+ circulating precursor cells participate in capillary restoration after hyperoxia acute lung injury (HALI). Journal of cellular and molecular medicine\| PubMed ID: 19426150	2009
CD133 expression defines a tumor initiating cell population in primary human ovarian cancer. Stem cells (Dayton, Ohio)\| PubMed ID: 19816957	2009
Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20194748	2010
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature\| PubMed ID: 20305640	2010
The HSC niche concept has turned 31. Has our knowledge matured? Annals of the New York Academy of Sciences\| PubMed ID: 20392212	2010
MicroRNA miR-125a controls hematopoietic stem cell number. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20616003	2010
Vitamin D receptor deletion leads to increased hematopoietic stem and progenitor cells residing in the spleen. Blood\| PubMed ID: 20664059	2010
Stem cells and DNA damage: persist or perish? Cell\| PubMed ID: 20691895	2010
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature\| PubMed ID: 20703299	2010
A microRNA regulating adult hematopoietic stem cells. Cell cycle (Georgetown, Tex.)\| PubMed ID: 20855952	2010
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature\| PubMed ID: 21124451	2010
In vivo imaging of transplanted hematopoietic stem and progenitor cells in mouse calvarium bone marrow. Nature protocols\| PubMed ID: 21212779	2011
Biomimetic platforms for human stem cell research. Cell stem cell\| PubMed ID: 21362565	2011
Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood\| PubMed ID: 21393479	2011
Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 21606370	2011
Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification. Blood\| PubMed ID: 21653327	2011
In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature\| PubMed ID: 21654805	2011
Differential niche and Wnt requirements during acute myeloid leukemia progression. Blood\| PubMed ID: 21765021	2011
AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell\| PubMed ID: 21884932	2011
Diabetes impairs hematopoietic stem cell mobilization by altering niche function. Science translational medicine\| PubMed ID: 21998408	2011
NF-Y is necessary for hematopoietic stem cell proliferation and survival. Blood\| PubMed ID: 22072554	2012
The haematopoietic stem cell niche at a glance. Journal of cell science\| PubMed ID: 22083139	2011
The bone marrow at the crossroads of blood and immunity. Nature reviews. Immunology\| PubMed ID: 22193770	2012
The hematopoietic stem cell niche. Frontiers in bioscience : a journal and virtual library\| PubMed ID: 22201730	2012
Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. Cell stem cell\| PubMed ID: 22385654	2012
A randomized controlled trial of highly active antiretroviral therapy versus highly active antiretroviral therapy and chemotherapy in therapy-naive patients with HIV-associated Kaposi sarcom... Journal of acquired immune deficiency syndromes (1999)\| PubMed ID: 22395672	2012
Deconstructing the complexity of a microenvironmental niche. Cell\| PubMed ID: 22464318	2012
The secrets of the bone marrow niche: Metabolic priming for AML. Nature medicine\| PubMed ID: 22673998	2012
Rethinking stroma: lessons from the blood. Cell stem cell\| PubMed ID: 22704500	2012
Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22826226	2012
The stem cell niche: tissue physiology at a single cell level. The Journal of clinical investigation\| PubMed ID: 22945635	2012
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell stem cell\| PubMed ID: 22958934	2012
Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23012470	2012
Fate through fat: lipid metabolism determines stem cell division outcome. Cell metabolism\| PubMed ID: 23040066	2012
Advances in the biology and therapy of chronic myeloid leukemia: proceedings from the 6th Post-ASH International Chronic Myeloid Leukemia and Myeloproliferative Neoplasms Workshop. Leukemia & lymphoma\| PubMed ID: 23121619	2013
Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling. Blood\| PubMed ID: 23160461	2013
The hematopoietic stem cell niche--home for friend and foe? Cytometry. Part B, Clinical cytometry\| PubMed ID: 23281119	2013
SIRT3 reverses aging-associated degeneration. Cell reports\| PubMed ID: 23375372	2013
Xist RNA is a potent suppressor of hematologic cancer in mice. Cell\| PubMed ID: 23415223	2013
BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. The Journal of clinical investigation\| PubMed ID: 23454749	2013
Differential stem- and progenitor-cell trafficking by prostaglandin E2. Nature\| PubMed ID: 23485965	2013
Influenza, but not HIV-specific CTL epitopes, elicits delayed-type hypersensitivity (DTH) reactions in HIV-infected patients. European journal of immunology\| PubMed ID: 23504637	2013
In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. Cancer cell\| PubMed ID: 23770013	2013
Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 23861493	2013
Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label. PloS one\| PubMed ID: 23990881	2013
Prostaglandin-modulated umbilical cord blood hematopoietic stem cell transplantation. Blood\| PubMed ID: 23996087	2013
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nature chemical biology\| PubMed ID: 24161946	2013
Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nature medicine\| PubMed ID: 24162813	2013
Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia. Cancer cell\| PubMed ID: 24183681	2013
Modeling human hematopoietic stem cell biology in the mouse. Seminars in hematology\| PubMed ID: 24216169	2013
Correction: Tracking Single Cells in Live Animals Using a Photoconvertible Near-Infrared Cell Membrane Label. PloS one\| PubMed ID: 24250779	2013
Blood scent. Cell\| PubMed ID: 24267883	2013
Genome-wide map of nuclear protein degradation shows NCoR1 turnover as a key to mitochondrial gene regulation. Cell\| PubMed ID: 24315104	2013
The bone marrow niche for haematopoietic stem cells. Nature\| PubMed ID: 24429631	2014
Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89. Stem cells (Dayton, Ohio)\| PubMed ID: 24549639	2014
Bone's dark side: mutated osteoblasts implicated in leukemia. Cell research\| PubMed ID: 24589711	2014
Direct measurement of local oxygen concentration in the bone marrow of live animals. Nature\| PubMed ID: 24590072	2014
Nice neighborhood: emerging concepts of the stem cell niche. Cell\| PubMed ID: 24679525	2014
Tic-TACs: Refreshing Hair Growth. Cell\| PubMed ID: 24813602	2014
Bayesian approach to single-cell differential expression analysis. Nature methods\| PubMed ID: 24836921	2014
Mesenchymal Cell Contributions to the Stem Cell Niche. Cell stem cell\| PubMed ID: 25748931	2015
Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention. Stem cells (Dayton, Ohio)\| PubMed ID: 25851125	2015
Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow. The Journal of experimental medicine\| PubMed ID: 25918341	2015
Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells. Cell stem cell\| PubMed ID: 25957903	2015
Harnessing the apoptotic programs in cancer stem-like cells. EMBO reports\| PubMed ID: 26253117	2015
Engineering pulmonary vasculature in decellularized rat and human lungs. Nature biotechnology\| PubMed ID: 26368048	2015
Global transcriptome analysis of T-competent progenitors in the bone marrow. Genomics data\| PubMed ID: 26484235	2015
Transcriptome comparison of distinct osteolineage subsets in the hematopoietic stem cell niche using a triple fluorescent transgenic mouse model. Genomics data\| PubMed ID: 26484277	2015
A hostel for the hostile: the bone marrow niche in hematologic neoplasms. Haematologica\| PubMed ID: 26521296	2015
Not All Created Equal: Lineage Hard-Wiring in the Production of Blood. Cell\| PubMed ID: 26687347	2015
Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26831087	2016
Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature\| PubMed ID: 27074509	2016
Hematopoietic Stem Cell and Its Bone Marrow Niche. Current topics in developmental biology\| PubMed ID: 27137653	2016
Blood and Bone. The New England journal of medicine\| PubMed ID: 27168440	2016
Heterogeneity of the bone marrow niche. Current opinion in hematology\| PubMed ID: 27177311	2016
Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse. Stem cell reports\| PubMed ID: 27185283	2016
Hematopoietic Stem Cell Niche in Health and Disease. Annual review of pathology\| PubMed ID: 27193455	2016
Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Nature biotechnology\| PubMed ID: 27272386	2016
Targeting the Warburg effect for leukemia therapy: Magnitude matters. Molecular & cellular oncology\| PubMed ID: 27308458	2015
Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow. Stem cell reports\| PubMed ID: 27453006	2016
Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells. Cell\| PubMed ID: 27518564	2016
Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators. Cell stem cell\| PubMed ID: 27524439	2016
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2. Molecular cell\| PubMed ID: 27635760	2016
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell\| PubMed ID: 27641501	2016
Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment. Nature\| PubMed ID: 27783593	2016
Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells. Cell\| PubMed ID: 27863245	2016
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease. Nature medicine\| PubMed ID: 27941791	2017
Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS medicinal chemistry letters\| PubMed ID: 27994748	2016
Shipping mouse bone marrow: Keep it in the bone. Experimental hematology\| PubMed ID: 28043821	2017
Hematopoiesis: Reconciling Historic Controversies about the Niche. Cell stem cell\| PubMed ID: 28475884	2017
ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells. Blood\| PubMed ID: 28615219	2017
The metabolic regulator mTORC1 controls terminal myeloid differentiation. Science immunology\| PubMed ID: 28763796	2017
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF neutrophils. Science (New York, N.Y.)\| PubMed ID: 29191879	2017
Bone marrow drives central nervous system regeneration after radiation injury. The Journal of clinical investigation\| PubMed ID: 29202481	2018
Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell. Cell\| PubMed ID: 29224778	2018
deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm. Blood advances\| PubMed ID: 29514790	2018
The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model. The Journal of clinical investigation\| PubMed ID: 29781813	2018
dropEst: pipeline for accurate estimation of molecular counts in droplet-based single-cell RNA-seq experiments. Genome biology\| PubMed ID: 29921301	2018
Modulating Bone Marrow Hematopoietic Lineage Potential to Prevent Bone Metastasis in Breast Cancer. Cancer research\| PubMed ID: 30065048	2018
Cell Cycle Analysis of Hematopoietic Stem and Progenitor Cells by Multicolor Flow Cytometry. Current protocols in cytometry\| PubMed ID: 30335223	2019
Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. Nature communications\| PubMed ID: 30728354	2019
An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation. Nature biotechnology\| PubMed ID: 30742125	2019
Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke. Circulation research\| PubMed ID: 30782088	2019
Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics. Cell stem cell\| PubMed ID: 30880025	2019
The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies. Leukemia\| PubMed ID: 30940908	2019
Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress. Cell stem cell\| PubMed ID: 31006621	2019
A Cellular Taxonomy of the Bone Marrow Stroma in Homeostasis and Leukemia. Cell\| PubMed ID: 31130381	2019
Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping. Cell stem cell\| PubMed ID: 31279774	2019
Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells. Nature medicine\| PubMed ID: 31700184	2019
Metcalf Lecture Award: Applying niche biology to engineer T-cell regenerative therapies. Experimental hematology\| PubMed ID: 31765673	2019
A biomaterial-based vaccine eliciting durable tumour-specific responses against acute myeloid leukaemia. Nature biomedical engineering\| PubMed ID: 31937942	2020
Lipid availability determines fate of skeletal progenitor cells via SOX9. Nature\| PubMed ID: 32103177	2020
Efficacy and safety of anti-CD45-saporin as conditioning agent for RAG deficiency. The Journal of allergy and clinical immunology\| PubMed ID: 32387109	2021
Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers. Blood\| PubMed ID: 32458004	2020
C9orf72 suppresses systemic and neural inflammation induced by gut bacteria. Nature\| PubMed ID: 32483373	2020
Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. Cell metabolism\| PubMed ID: 32763164	2020
Adult blood stem cell localization reflects the abundance of reported bone marrow niche cell types and their combinations. Blood\| PubMed ID: 32766876	2020
Cell interactions in the bone marrow microenvironment affecting myeloid malignancies. Blood advances\| PubMed ID: 32780848	2020
Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress. Cell reports\| PubMed ID: 32877669	2020
Progression signature underlies clonal evolution and dissemination of multiple myeloma. Blood\| PubMed ID: 33150374	2021
Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML. Nature communications\| PubMed ID: 33431855	2021
Young haematopoietic stem cells are picky eaters. Cell research\| PubMed ID: 33633351	2021
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis. Cell metabolism\| PubMed ID: 33770508	2021
Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics. Science signaling\| PubMed ID: 34103421	2021
In memory of Paul Sylvain Frenette, a pioneering explorer of the hematopoietic stem cell niche who left far too early. Experimental hematology\| PubMed ID: 34403758	2021
tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche. Cell stem cell\| PubMed ID: 34551362	2021
Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth. Blood\| PubMed ID: 34610101	2022
Author Correction: An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation. Nature biotechnology\| PubMed ID: 34663922	2021
Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment. Cancer cell\| PubMed ID: 34719426	2021
Analysis of Leukemia Cell Metabolism through Stable Isotope Tracing in Mice. Bio-protocol\| PubMed ID: 34722818	2021
Chromatin-state barriers enforce an irreversible mammalian cell fate decision. Cell reports\| PubMed ID: 34758323	2021
Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation. Blood cancer journal\| PubMed ID: 34864816	2021
What is the role of the bone marrow microenvironment in AML? Best practice & research. Clinical haematology\| PubMed ID: 34865700	2021
B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis. Nature immunology\| PubMed ID: 35352063	2022
Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis. Nature immunology\| PubMed ID: 35705799	2022
Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease. Nature cardiovascular research\| PubMed ID: 35747128	2022
In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies. Blood advances\| PubMed ID: 35793392	2022
Recent advances in "sickle and niche" research - Tribute to Dr. Paul S Frenette. Stem cell reports\| PubMed ID: 35830837	2022
Sleep exerts lasting effects on hematopoietic stem cell function and diversity. The Journal of experimental medicine\| PubMed ID: 36129517	2022
A transcriptional metastatic signature predicts survival in clear cell renal cell carcinoma. Nature communications\| PubMed ID: 36180422	2022
Isolation of Thymus Stromal Cells from Human and Murine Tissue. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 36255703	2023
Defocus Corrected Large Area Cryo-EM (DeCo-LACE) for label-free detection of molecules across entire cell sections. eLife\| PubMed ID: 36382886	2022
Image-seq: spatially resolved single-cell sequencing guided by in situ and in vivo imaging. Nature methods\| PubMed ID: 36424441	2022
Immune-responsive biodegradable scaffolds for enhancing neutrophil regeneration. Bioengineering & translational medicine\| PubMed ID: 36684088	2023
Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses. Nature communications\| PubMed ID: 36750562	2023
Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors. Blood\| PubMed ID: 37267513	2023
The bone marrow stroma in human myelodysplastic syndrome reveals alterations that regulate disease progression. Blood advances\| PubMed ID: 37450380	2023
Health Consequences of Thymus Removal in Adults. The New England journal of medicine\| PubMed ID: 37530823	2023
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy. Blood\| PubMed ID: 37595362	2023
Adult Prg4+ progenitors repair long-term articular cartilage wounds in vivo. JCI insight\| PubMed ID: 37681409	2023
Clearing and replacing tissue-resident myeloid cells with an anti-CD45 antibody-drug conjugate. Blood advances\| PubMed ID: 37748049	2023
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