John M. Leong

Extracellular Adenosine Protects against Streptococcus pneumoniae Lung Infection by Regulating Pulmonary Neutrophil Recruitment.

Calpain mediates epithelial cell microvillar effacement by enterohemorrhagic Escherichia coli.

Enhanced Actin Pedestal Formation by Enterohemorrhagic Escherichia coli O157:H7 Adapted to the Mammalian Host.

Allele- and tir-independent functions of intimin in diverse animal infection models.

Membrane-deforming proteins play distinct roles in actin pedestal biogenesis by enterohemorrhagic Escherichia coli.

TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.

Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.

A novel murine infection model for Shiga toxin-producing Escherichia coli.

Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence.

The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment.

Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome.

Identification of lysine residues in the Borrelia burgdorferi DbpA adhesin required for murine infection.

Actin pedestal formation by enterohemorrhagic Escherichia coli enhances bacterial host cell attachment and concomitant type III translocation.

Strain-specific variation of the decorin-binding adhesin DbpA influences the tissue tropism of the lyme disease spirochete.

Effects of Shiga toxin type 2 on a bioengineered three-dimensional model of human renal tissue.

Glycosaminoglycan binding by Borrelia burgdorferi adhesin BBK32 specifically and uniquely promotes joint colonization.

The α-tocopherol form of vitamin E reverses age-associated susceptibility to streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment.

Integrin binding by Borrelia burgdorferi P66 facilitates dissemination but is not required for infectivity.

Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete.

Middle region of the Borrelia burgdorferi surface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection.

Activation of the Classical Mitogen-Activated Protein Kinases Is Part of the Shiga Toxin-Induced Ribotoxic Stress Response and May Contribute to Shiga Toxin-Induced Inflammation.

A Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response.

Synchronous Disease Kinetics in a Murine Model for Enterohemorrhagic Infection Using Food-Borne Inoculation.

Cytosolic Phospholipase Aα Promotes Pulmonary Inflammation and Systemic Disease during Streptococcus pneumoniae Infection.

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.

Characterization of Borrelia burgdorferi Binding to Mammalian Cells and Extracellular Matrix.

Correction for Jandhyala et al., "Activation of the Classical Mitogen-Activated Protein Kinases Is Part of the Shiga Toxin-Induced Ribotoxic Stress Response and May Contribute to Shiga Toxin-Induced Inflammation".

Pearls collections: What we can learn about infectious disease and cancer.

Plasticity in early immune evasion strategies of a bacterial pathogen.

Nasopharyngeal Exposure to Induces Extended Age-Dependent Protection against Pulmonary Infection Mediated by Antibodies and CD138 Cells.

Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal Barrier.

Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection.

A1 adenosine receptor signaling reduces Streptococcus pneumoniae adherence to pulmonary epithelial cells by targeting expression of platelet-activating factor receptor.

Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Infection.

Extracellular adenosine enhances the ability of PMNs to kill Streptococcus pneumoniae by inhibiting IL-10 production.

Strain-specific joint invasion and colonization by Lyme disease spirochetes is promoted by outer surface protein C.

Macrophage LC3-associated phagocytosis is an immune defense against that diminishes with host aging.

Citrobacter rodentium Lysogenized with a Shiga Toxin-Producing Phage: A Murine Model for Shiga Toxin-Producing E. coli Infection.

A Murine Model for Enhancement of Streptococcus pneumoniae Pathogenicity upon Viral Infection and Advanced Age.

Host-informed therapies for the treatment of pneumococcal pneumonia.

Scalable Reporter Assays to Analyze the Regulation of Expression in Shiga Toxin-Producing Enteropathogens.

Editorial overview of Pearls Microbiome Series: E pluribus unum.

Citrobacter rodentium(ϕStx2dact), a murine infection model for enterohemorrhagic Escherichia coli.

The Yin and Yang of Pneumolysin During Pneumococcal Infection.

VlsE, the nexus for antigenic variation of the Lyme disease spirochete, also mediates early bacterial attachment to the host microvasculature under shear force.

Single domain antibodies against enteric pathogen virulence factors are active as curli fiber fusions on probiotic E. coli Nissle 1917.