David R. Hinton

Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system.

Kinetics of cytokine mRNA expression in the central nervous system following lethal and nonlethal coronavirus-induced acute encephalomyelitis.

Expression of interferon-gamma by a coronavirus defective-interfering RNA vector and its effect on viral replication, spread, and pathogenicity.

Expression of hemagglutinin/esterase by a mouse hepatitis virus coronavirus defective-interfering RNA alters viral pathogenesis.

Transgenic interleukin 10 prevents induction of experimental autoimmune encephalomyelitis.

Viral induced demyelination.

Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants.

Matrix metalloproteinase expression correlates with virulence following neurotropic mouse hepatitis virus infection.

Regulation of RPE intercellular junction integrity and function by hepatocyte growth factor.

The art of survival during viral persistence.

Neutrophils promote mononuclear cell infiltration during viral-induced encephalitis.

A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization.

Developmental retinal apoptosis in Ku86-/- mice.

Hepatocyte growth factor and its role in the pathogenesis of retinal detachment.

Mouse strain-dependent heterogeneity of resting limbal vasculature.

Perforin and gamma interferon-mediated control of coronavirus central nervous system infection by CD8 T cells in the absence of CD4 T cells.

Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy.

Gene therapy in a murine model for clinical application to multiple sclerosis.

Ceramide-induced apoptosis: role of catalase and hepatocyte growth factor.

Differential regulation of primary and secondary CD8+ T cells in the central nervous system.

Expression of a dominant negative IFN-gammareceptor on mouse oligodendrocytes.

Expression of matrix metalloproteinases and their tissue inhibitor during viral encephalitis.

Maintenance of CD8+ T cells during acute viral infection of the central nervous system requires CD4+ T cells but not interleukin-2.

Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization.

A selective cyclic integrin antagonist blocks the integrin receptors alphavbeta3 and alphavbeta5 and inhibits retinal pigment epithelium cell attachment, migration and invasion.

Neutrophils promote experimental choroidal neovascularization.

Protection from oxidative stress by methionine sulfoxide reductases in RPE cells.

Astrocyte expression of a dominant-negative interferon-gamma receptor.

In vivo expression of GFP transgene delivered via a replicating feline leukemia virus.

Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells.

Soluble EphB4 regulates choroidal endothelial cell function and inhibits laser-induced choroidal neovascularization.

Neuropilin-1 expression by endothelial cells and retinal pigment epithelial cells in choroidal neovascular membranes.

Characterization of brimonidine transport in retinal pigment epithelium.

CNS viral infection diverts homing of antibody-secreting cells from lymphoid organs to the CNS.

Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination.

Mouse hepatitis virus pathogenesis in the central nervous system is independent of IL-15 and natural killer cells.

Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor.

MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes.

Expression of protein kinase CK2 in astroglial cells of normal and neovascularized retina.

Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells.

Altered neuroantigen-specific cytokine secretion in a Th2 environment reduces experimental autoimmune encephalomyelitis.

Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitis.

Population-based study of early age-related macular degeneration: role of the complement factor H Y402H polymorphism in bilateral but not unilateral disease.

Stimulation of apical and basolateral VEGF-A and VEGF-C secretion by oxidative stress in polarized retinal pigment epithelial cells.

Thrombospondin-1 expression in RPE and choroidal neovascular membranes.

In vivo models of proliferative vitreoretinopathy.

alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress.

Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells.

CD4 T cells contribute to virus control and pathology following central nervous system infection with neurotropic mouse hepatitis virus.

Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia.

Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells.

N-(4-hydroxyphenyl) retinamide augments laser-induced choroidal neovascularization in mice.

Connective tissue growth factor as a mediator of intraocular fibrosis.

The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitis.

Paclitaxel Induces Apoptosis in AIDS-Related Kaposi's Sarcoma Cells.

Toll-like receptor 3 and geographic atrophy in age-related macular degeneration.

Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis.

Regulation of thioredoxin by ceramide in retinal pigment epithelial cells.

Immunocytochemical analysis of retinal neurons under electrical stimulation.

BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration.

Regulated secretion of complement factor H by RPE and its role in RPE migration.

A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells.

Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells.

Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro.

Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration.

RNase L mediated protection from virus induced demyelination.

Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis.

alphaB-crystallin regulation of angiogenesis by modulation of VEGF.

Gamma interferon signaling in oligodendrocytes is critical for protection from neurotropic coronavirus infection.

What determines the switch between atrophic and neovascular forms of age related macular degeneration? - the role of BMP4 induced senescence.

Neutrophils compromise retinal pigment epithelial barrier integrity.

Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration.

Recombinant human VEGF165b inhibits experimental choroidal neovascularization.

Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis.

Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species.

αB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells.

Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis.

Vitreal oxygenation in retinal ischemia reperfusion.

Polarized secretion of PEDF from human embryonic stem cell-derived RPE promotes retinal progenitor cell survival.

Factors supporting intrathecal humoral responses following viral encephalomyelitis.

Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis.

Sonoporation enhances chemotherapeutic efficacy in retinoblastoma cells in vitro.

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.

Antenatal maternal stress alters functional brain responses in adult offspring during conditioned fear.

Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration.

CXCR3-dependent plasma blast migration to the central nervous system during viral encephalomyelitis.

Shifting hierarchies of interleukin-10-producing T cell populations in the central nervous system during acute and persistent viral encephalomyelitis.

Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFβ2 and its receptor TGFβRII.

Methionine sulfoxide reductase A: Structure, function and role in ocular pathology.

VEGF and PEDF secretion in ARPE-19 and fhRPE cells.

WT1 mutants reveal SRPK1 to be a downstream angiogenesis target by altering VEGF splicing.

CD4 T cells promote CD8 T cell immunity at the priming and effector site during viral encephalitis.

Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9.

Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux.

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.

IFN-γ protects from lethal IL-17 mediated viral encephalomyelitis independent of neutrophils.

Novel roles for α-crystallins in retinal function and disease.

Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction.

IFN-γ signaling to astrocytes protects from autoimmune mediated neurological disability.

A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer.

ERK1/2 activation is a therapeutic target in age-related macular degeneration.

Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Cε.

Angiofibrotic response to vascular endothelial growth factor inhibition in diabetic retinal detachment: report no. 1.

GRP78 plays an essential role in adipogenesis and postnatal growth in mice.

Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis.

Astrocyte-derived CXCL10 drives accumulation of antibody-secreting cells in the central nervous system during viral encephalomyelitis.

Antiapoptotic properties of α-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells.

Subretinal implantation of retinal pigment epithelial cells derived from human embryonic stem cells: improved survival when implanted as a monolayer.

IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis.

TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy.

MMP-independent role of TIMP-1 at the blood brain barrier during viral encephalomyelitis.

Ifit2 deficiency results in uncontrolled neurotropic coronavirus replication and enhanced encephalitis via impaired alpha/beta interferon induction in macrophages.

Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system.

PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis.

Ceramide inhibits connective tissue growth factor expression by human retinal pigment epithelial cells.

Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells.

Protection of retina by αB crystallin in sodium iodate induced retinal degeneration.

IL-27 limits central nervous system viral clearance by promoting IL-10 and enhances demyelination.

Distinct CD4 T-cell effects on primary versus recall CD8 T-cell responses during viral encephalomyelitis.

DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.

Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-α.

Polarized human embryonic stem cell-derived retinal pigment epithelial cell monolayers have higher resistance to oxidative stress-induced cell death than nonpolarized cultures.

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity.

IL-18 is not therapeutic for neovascular age-related macular degeneration.

TGF-β2 secretion from RPE decreases with polarization and becomes apically oriented.

Sodium iodate induced retinal degeneration: new insights from an old model.

Molecular mechanisms of subretinal fibrosis in age-related macular degeneration.

Attenuation of choroidal neovascularization by histone deacetylase inhibitor.

Astrocyte response to IFN-γ limits IL-6-mediated microglia activation and progressive autoimmune encephalomyelitis.

Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration.

Stem cell based therapies for age-related macular degeneration: The promises and the challenges.

Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination.

Myd88 Initiates Early Innate Immune Responses and Promotes CD4 T Cells during Coronavirus Encephalomyelitis.

SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization.

Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy.

Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy.

Aqueous Angiography: Real-Time and Physiologic Aqueous Humor Outflow Imaging.

αB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition.

Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis.

The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction.

Targeting of exon VI-skipping human RGR-opsin to the plasma membrane of pigment epithelium and co-localization with terminal complement complex C5b-9.

Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats.

Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs.

Aqueous Angiography-Mediated Guidance of Trabecular Bypass Improves Angiographic Outflow in Human Enucleated Eyes.

Differential Regulation of Self-reactive CD4 T Cells in Cervical Lymph Nodes and Central Nervous System during Viral Encephalomyelitis.

Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione.

Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes.

Endoplasmic reticulum-mitochondrial crosstalk: a novel role for the mitochondrial peptide humanin.

Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease.

Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells.

Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models.

Development of a new tissue injector for subretinal transplantation of human embryonic stem cell derived retinal pigmented epithelium.

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.

APOPTOSIS AND ANGIOFIBROSIS IN DIABETIC TRACTIONAL MEMBRANES AFTER VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITION: Results of a Prospective Trial. Report No. 2.

A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration.

Intra-vitreal αB crystallin fused to elastin-like polypeptide provides neuroprotection in a mouse model of age-related macular degeneration.

Mechanism of cytokinesis failure in ovarian cystadenomas with defective BRCA1 and P53 pathways.

A new immunodeficient retinal dystrophic rat model for transplantation studies using human-derived cells.

Characterization and Regulation of Carrier Proteins of Mitochondrial Glutathione Uptake in Human Retinal Pigment Epithelium Cells.

Histopathologic Assessment of Optic Nerves and Retina From a Patient With Chronically Implanted Argus II Retinal Prosthesis System.

A Novel HDL-Mimetic Peptide HM-10/10 Protects RPE and Photoreceptors in Murine Models of Retinal Degeneration.

Sympathetic Effects of Internal Carotid Nerve Manipulation on Choroidal Vascularity and Related Measures.

The humanin peptide mediates ELP nanoassembly and protects human retinal pigment epithelial cells from oxidative stress.

Surgical Method for Implantation of a Biosynthetic Retinal Pigment Epithelium Monolayer for Geographic Atrophy: Experience from a Phase 1/2a Study.

Identification of early pericyte loss and vascular amyloidosis in Alzheimer's disease retina.

The Emerging Role of Senescence in Ocular Disease.

Cytoplasmic synthesis of endogenous complementary DNA via reverse transcription and implications in age-related macular degeneration.

Xeno-free cryopreservation of adherent retinal pigmented epithelium yields viable and functional cells in vitro and in vivo.

complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity.

One-Year Follow-Up in a Phase 1/2a Clinical Trial of an Allogeneic RPE Cell Bioengineered Implant for Advanced Dry Age-Related Macular Degeneration.

Long-Term Transplant Effects of iPSC-RPE Monolayer in Immunodeficient RCS Rats.

DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs.

Mechanisms of RPE senescence and potential role of αB crystallin peptide as a senolytic agent in experimental AMD.

Blocking Ocular Sympathetic Activity Inhibits Choroidal Neovascularization.

Survival of an HLA-mismatched, bioengineered RPE implant in dry age-related macular degeneration.