Christiane E. Wobus

The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity.

STAT1-dependent innate immunity to a Norwalk-like virus.

Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages.

Development of a microsphere-based serologic multiplexed fluorescent immunoassay and a reverse transcriptase PCR assay to detect murine norovirus 1 infection in mice.

Murine norovirus: a model system to study norovirus biology and pathogenesis.

VPg of murine norovirus binds translation initiation factors in infected cells.

Cleavage map and proteolytic processing of the murine norovirus nonstructural polyprotein in infected cells.

Pathology of immunodeficient mice with naturally occurring murine norovirus infection.

Murine norovirus 1 infection is associated with histopathological changes in immunocompetent hosts, but clinical disease is prevented by STAT1-dependent interferon responses.

Recovery of infectious murine norovirus using pol II-driven expression of full-length cDNA.

Murine noroviruses comprising a single genogroup exhibit biological diversity despite limited sequence divergence.

Detection of murine norovirus 1 by using plaque assay, transfection assay, and real-time reverse transcription-PCR before and after heat exposure.

Structure of antibody-neutralized murine norovirus and unexpected differences from viruslike particles.

Antibody is critical for the clearance of murine norovirus infection.

Ganglioside-linked terminal sialic acid moieties on murine macrophages function as attachment receptors for murine noroviruses.

Murine norovirus-1 entry into permissive macrophages and dendritic cells is pH-independent.

High-resolution x-ray structure and functional analysis of the murine norovirus 1 capsid protein protruding domain.

High-resolution cryo-electron microscopy structures of murine norovirus 1 and rabbit hemorrhagic disease virus reveal marked flexibility in the receptor binding domains.

Endocytosis of murine norovirus 1 into murine macrophages is dependent on dynamin II and cholesterol.

Transient or persistent norovirus infection does not alter the pathology of Salmonella typhimurium induced intestinal inflammation and fibrosis in mice.

A small molecule deubiquitinase inhibitor increases localization of inducible nitric oxide synthase to the macrophage phagosome and enhances bacterial killing.

Glycosphingolipids as receptors for non-enveloped viruses.

Murine noroviruses bind glycolipid and glycoprotein attachment receptors in a strain-dependent manner.

Viruses are everywhere-what do we do?

Antiviral Activity of a Small Molecule Deubiquitinase Inhibitor Occurs via Induction of the Unfolded Protein Response.