George J. Murphy

Manipulation of mouse hematopoietic progenitors by specific retroviral infection.

LPAM (alpha 4 beta 7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease.

Manipulation of gene expression in megakaryocytes.

Using retroviruses to express genes in primary megakaryocyte lineage cells.

Exogenous control of mammalian gene expression via modulation of translational termination.

Induced pluripotent stem cell generation using a single lentiviral stem cell cassette.

Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector.

Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages.

Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.

Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes.