Paul Gadue

NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation.

The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity.

Restoration of NK T cell development in fyn-mutant mice by a TCR reveals a requirement for Fyn during early NK T cell ontogeny.

Germ layer induction from embryonic stem cells.

Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells.

BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.

Identification and targeting of the ROSA26 locus in human embryonic stem cells.

Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood.

Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast.

Epidermal cells rev up reprogramming.

Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm.

Stem cells unscramble yolk sac hematopoiesis.

Transcriptional competence and the active marking of tissue-specific enhancers by defined transcription factors in embryonic and induced pluripotent stem cells.

Generation of transgene-free lung disease-specific human induced pluripotent stem cells using a single excisable lentiviral stem cell cassette.

Liver regeneration from induced pluripotent stem cells.

A high-throughput multiplexed screening assay for optimizing serum-free differentiation protocols of human embryonic stem cells.

Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes.

An endothelial cell niche induces hepatic specification through dual repression of Wnt and Notch signaling.

High-throughput screening assay for embryoid body differentiation of human embryonic stem cells.

Self-renewing endodermal progenitor lines generated from human pluripotent stem cells.

Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells.

AAV-mediated gene therapy for choroideremia: preclinical studies in personalized models.

Ribosomal and hematopoietic defects in induced pluripotent stem cells derived from Diamond Blackfan anemia patients.

Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines.

High-level transgene expression in induced pluripotent stem cell-derived megakaryocytes: correction of Glanzmann thrombasthenia.

The negative impact of Wnt signaling on megakaryocyte and primitive erythroid progenitors derived from human embryonic stem cells.

Utilization of the AAVS1 safe harbor locus for hematopoietic specific transgene expression and gene knockdown in human ES cells.

Hematopoietic differentiation of pluripotent stem cells in culture.

Pluripotent stem cells reveal erythroid-specific activities of the GATA1 N-terminus.

A Doxycycline-Inducible System for Genetic Correction of iPSC Disease Models.

Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells.

Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale.

Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells.

OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus during Human ES Cell Differentiation into Definitive Endoderm.

Generation of poikiloderma with neutropenia (PN) induced pluripotent stem cells (iPSCs).

Generation of human control iPS cell line CHOPWT9 from healthy adult peripheral blood mononuclear cells.

Generation of Hermansky-Pudlak Syndrome Type 1 (HPS1) induced pluripotent stem cells (iPSCs).

Generation of Hermansky Pudlak syndrome type 2 (HPS2) induced pluripotent stem cells (iPSCs).

Generation of human control iPS cell line CHOPWT10 from healthy adult peripheral blood mononuclear cells.

GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells.

Induced Pluripotent Stem Cell-Derived Megakaryocytes and Platelets for Disease Modeling and Future Clinical Applications.

Exploring the Interaction Between eIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain.

GATA6 suppression enhances lung specification from human pluripotent stem cells.

Generation of a human Juvenile myelomonocytic leukemia iPSC line, CHOPi001-A, with a mutation in CBL.

Highly Efficient CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells.

Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene.

Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A.