James West

Fetal and maternal thyroid hormone responses to ethanol exposure during the third trimester equivalent of gestation in sheep.

Pseudomonas aeruginosa-human airway epithelial cell interaction: effects of iron on inflammation and apoptosis.

Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein.

Fetal alcohol exposure and temporal vulnerability: effects of binge-like alcohol exposure on the developing rat hippocampus.

Blood ethanol concentration profiles: a comparison between rats and mice.

Alcohol and nutritional control treatments during neurogenesis in rat brain reduce total neuron number in locus coeruleus, but not in cerebellum or inferior olive.

Low-loss hollow-core silica/air photonic bandgap fibre.

A beam tracing method for interactive architectural acoustics.

Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle.

Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation.

Developmental alcohol exposure disrupts circadian regulation of BDNF in the rat suprachiasmatic nucleus.

Adenoviral gene transfer to the neonatal rat pulmonary circulation.

Developmental alcohol exposure alters light-induced phase shifts of the circadian activity rhythm in rats.

Long-term alcohol exposure prior to conception results in lower fetal body weights.

Alcohol and the developing brain: neuroanatomical studies.

Tumor necrosis factor-related apoptosis-inducing ligand can induce apoptosis in subsets of premalignant cells.

Modulation of DNA fragmentation factor 40 nuclease activity by poly(ADP-ribose) polymerase-1.

Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes.

Fetal alcohol syndrome: an assessment of the field.

General discussion at the fetal alcohol syndrome symposium.

Complications from olanzapine in a mentally healthy patient.

Neonatal alcohol exposure permanently disrupts the circadian properties and photic entrainment of the activity rhythm in adult rats.

Alterations in gene expression induced by the lipid peroxidation product, 4-hydroxy-2-nonenal.

BMP signaling controls PASMC KV channel expression in vitro and in vivo.

Suppression of type II bone morphogenic protein receptor in vascular smooth muscle induces pulmonary arterial hypertension in transgenic mice.

Interleukin-6 causes mild pulmonary hypertension and augments hypoxia-induced pulmonary hypertension in mice.

A bone-derived mixture of TGF beta-superfamily members forms a more mature vascular network than bFGF or TGF-beta 2 in vivo.

Noise levels in Johns Hopkins Hospital.

Perspectives on the Massachusetts Community Health Information Profile (MassCHIP): developing an online data query system to target a variety of user needs and capabilities.

Embryonic growth-associated protein is one subunit of a novel N-terminal acetyltransferase complex essential for embryonic vascular development.

Endogenous reactive intermediates as modulators of cell signaling and cell death.

Long-term effects of neonatal alcohol exposure on photic reentrainment and phase-shifting responses of the activity rhythm in adult rats.

Nicotine decreases blood alcohol concentrations in adult rats: a phenomenon potentially related to gastric function.

Binge alcohol exposure during all three trimesters alters bone strength and growth in fetal sheep.

Uptake and elimination of ethanol by young zebrafish embryos.

Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle.

Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH.

Noise in the adult emergency department of Johns Hopkins Hospital.

Ethical issues and new nurses: preventing ethical distress in the work environment.

Chronic ethanol increases fetal cerebral blood flow specific to the ethanol-sensitive cerebellum under normoxaemic, hypercapnic and acidaemic conditions: ovine model.

Noise in the operating rooms of Johns Hopkins Hospital.

Quieting Weinberg 5C: a case study in hospital noise control.

Serotonin transporter protein in pulmonary hypertensive rats treated with atorvastatin.

Temporal vulnerability of fetal cerebellar Purkinje cells to chronic binge alcohol exposure: ovine model.

The relationship between distance to hospital and patient mortality in emergencies: an observational study.

Monitoring uterine contractility in mice using a transcervical intrauterine pressure catheter.

Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F.

Solution-processed organic field-effect transistors and unipolar inverters using self-assembled interface dipoles on gate dielectrics.

Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule.

Neonatal alcohol exposure differentially alters clock gene oscillations within the suprachiasmatic nucleus, cerebellum, and liver of adult rats.

Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways.

Spatial extent, magnitude, and patterns of persistent organochlorine pollutants in Pacific herring (Clupea pallasi) populations in the Puget Sound (USA) and Strait of Georgia (Canada).

Alcohol exposure on postnatal day 5 induces Purkinje cell loss and evidence of Purkinje cell degradation in lobule I of rat cerebellum.

Xenoestrogen exposure and effects in English sole (Parophrys vetulus) from Puget Sound, WA.

Murine pulmonary response to chronic hypoxia is strain specific.

Circulating RNA transcripts identify therapeutic response in cystic fibrosis lung disease.

Mice expressing BMPR2R899X transgene in smooth muscle develop pulmonary vascular lesions.

Gene expression in BMPR2 mutation carriers with and without evidence of pulmonary arterial hypertension suggests pathways relevant to disease penetrance.

A noncoding RNA gene on chromosome 10p15.3 may function upstream of hTERT.

Gene expression in lungs of mice lacking the 5-hydroxytryptamine transporter gene.

Surface modes in air-core photonic band-gap fibers.

Protein microarray analysis of nasal polyps from aspirin-sensitive and aspirin-tolerant patients with chronic rhinosinusitis.

Copy-number variation in BMPR2 is not associated with the pathogenesis of pulmonary arterial hypertension.

Shock-synthesized hexagonal diamonds in Younger Dryas boundary sediments.

Effects of neonatal alcohol exposure on vasoactive intestinal polypeptide neurons in the rat suprachiasmatic nucleus.

Engineering of stable bispecific antibodies targeting IL-17A and IL-23.

Cross talk between Smad, MAPK, and actin in the etiology of pulmonary arterial hypertension.

Structure-activity comparison of the cytotoxic properties of diethyl maleate and related molecules: identification of diethyl acetylenedicarboxylate as a thiol cross-linking agent.

The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation.

Vstm3 is a member of the CD28 family and an important modulator of T-cell function.

Unrecognized glucose intolerance is common in pulmonary arterial hypertension.

Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor.

Disruption of bone morphogenetic protein receptor 2 (BMPR2) in mammary tumors promotes metastases through cell autonomous and paracrine mediators.

ACE2 improves right ventricular function in a pressure overload model.

Physiologic and molecular consequences of endothelial Bmpr2 mutation.

Permanent polarity and piezoelectricity of electrospun α-helical poly(α-amino acid) fibers.

Enhanced toxicity of the protein cross-linkers divinyl sulfone and diethyl acetylenedicarboxylate in comparison to related monofunctional electrophiles.

Are obliterative pulmonary vascular lesions reversible?

Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene.

Oxidative injury is a common consequence of BMPR2 mutations.

Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression.

Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension.

Unexpectedly high mortality in Pacific herring embryos exposed to the 2007 Cosco Busan oil spill in San Francisco Bay.

Computerised lung sound analysis to improve the specificity of paediatric pneumonia diagnosis in resource-poor settings: protocol and methods for an observational study.

Connectivity map analysis of nonsense-mediated decay-positive BMPR2-related hereditary pulmonary arterial hypertension provides insights into disease penetrance.

BMPR2 expression is suppressed by signaling through the estrogen receptor.

The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease.

Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension.

CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema.

Approximate entropy of network parameters.

Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise.

The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds.

Metabolomic analysis of bone morphogenetic protein receptor type 2 mutations in human pulmonary endothelium reveals widespread metabolic reprogramming.

Current clinical practice in postoperative endovascular aneurysm repair imaging surveillance.

Role of BMPR2 alternative splicing in heritable pulmonary arterial hypertension penetrance.

Longitudinal analysis casts doubt on the presence of genetic anticipation in heritable pulmonary arterial hypertension.

A potential role for Insulin resistance in experimental pulmonary hypertension.

Testosterone negatively regulates right ventricular load stress responses in mice.

Differential network entropy reveals cancer system hallmarks.

A practical guide to metabolomic profiling as a discovery tool for human heart disease.

Right ventricular systolic pressure measurements in combination with harvest of lung and immune tissue samples in mice.

A multiresolution analysis for detection of abnormal lung sounds.

A process-based review of mouse models of pulmonary hypertension.

Modification of hemodynamic and immune responses to exposure with a weak antigen by the expression of a hypomorphic BMPR2 gene.

Bifunctional electrophiles cross-link thioredoxins with redox relay partners in cells.

Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma.

Evaluation of novel disposable, light-weight radiation protection devices in an interventional radiology setting: a randomized controlled trial.

An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways.

Histone deacetylase inhibitor enhances recovery after AKI.

Dysfunctional resident lung mesenchymal stem cells contribute to pulmonary microvascular remodeling.

Endocrine disrupting chemicals in fish bile: a rapid method of analysis using English sole (Parophrys vetulus) from Puget Sound, WA, USA.

Experimental and transgenic models of pulmonary hypertension.

Hyperoxia synergizes with mutant bone morphogenic protein receptor 2 to cause metabolic stress, oxidant injury, and pulmonary hypertension.

Corruption of the intra-gene DNA methylation architecture is a hallmark of cancer.

Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

Distinctive topology of age-associated epigenetic drift in the human interactome.

The material footprint of nations.

Gender, sex hormones and pulmonary hypertension.

Author's Reply.

Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism.

Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index.

Pronounced Toxicity Differences between Homobifunctional Protein Cross-Linkers and Analogous Monofunctional Electrophiles.

A Metabolomics Investigation of Non-genotoxic Carcinogenicity in the Rat.

The performance enhancement of a micro-machined microphone based on field-effect-transistor and electrets.

Rankings versus reality in pancreatic cancer surgery: a real-world comparison.

Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development.

Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension.

Echocardiographic assessment of the right heart in mice.

Interaction between bone morphogenetic protein receptor type 2 and estrogenic compounds in pulmonary arterial hypertension.

Rescuing the BMPR2 signaling axis in pulmonary arterial hypertension.

Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.

Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension.

Influence of pulmonary emphysema on COPD assessment test-oriented categorization in GOLD document.

Estrogen Metabolite 16α-Hydroxyestrone Exacerbates Bone Morphogenetic Protein Receptor Type II-Associated Pulmonary Arterial Hypertension Through MicroRNA-29-Mediated Modulation of Cellular Metabolism.

Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation.

Bone Marrow-derived Cells Contribute to the Pathogenesis of Pulmonary Arterial Hypertension.

Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension.

Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial Hypertension.

Mechanisms of Lipid Accumulation in the Bone Morphogenetic Protein Receptor Type 2 Mutant Right Ventricle.

Endothelial-to-mesenchymal transition in lipopolysaccharide-induced acute lung injury drives a progenitor cell-like phenotype.

Antagonism of the thromboxane-prostanoid receptor is cardioprotective against right ventricular pressure overload.

Translational Advances in the Field of Pulmonary Hypertension Molecular Medicine of Pulmonary Arterial Hypertension. From Population Genetics to Precision Medicine and Gene Editing.

Reply: Expanded Role for Bone Marrow-derived Hematopoietic Stem and Progenitor Cells in Pulmonary Arterial Hypertension.

Scavengers of reactive γ-ketoaldehydes extend Caenorhabditis elegans lifespan and healthspan through protein-level interactions with SIR-2.1 and ETS-7.

Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series).

Genome Editing in Large Animals.

Genotype-phenotype effects of mutations on disease severity in mouse models of pulmonary hypertension.

Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction.

Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension.

The Relationship of Bone Mineral Density in Men with Chronic Obstructive Pulmonary Disease Classified According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) Combined Chronic Obstructive Pulmonary Disease (COPD) Assessment System.

Oestrogen inhibition reverses pulmonary arterial hypertension and associated metabolic defects.

Isolation and characterization of endothelial-to-mesenchymal transition cells in pulmonary arterial hypertension.

Vildagliptin ameliorates pulmonary fibrosis in lipopolysaccharide-induced lung injury by inhibiting endothelial-to-mesenchymal transition.

Upregulation of SERT and ADORA1 in broilers with acute right ventricular failure.

Precision Modeling of Pulmonary Hypertension Pathology with Induced Pluripotent Stem Cell-derived Cells.

The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury.

JNK2 regulates vascular remodeling in pulmonary hypertension.

rhACE2 Therapy Modifies Bleomycin-Induced Pulmonary Hypertension via Rescue of Vascular Remodeling.

A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension.

Ubiquitin chains: a new way of screening for regulatory differences in pulmonary hypertension.

Clinical and genetic associations with prostacyclin response in pulmonary arterial hypertension.

Pulmonary Vascular Platform Models the Effects of Flow and Pressure on Endothelial Dysfunction in Associated Pulmonary Arterial Hypertension.

Adverse physiologic effects of Western diet on right ventricular structure and function: role of lipid accumulation and metabolic therapy.

Bone Marrow-Derived Proangiogenic Cells Mediate Pulmonary Arteriole Stiffening via Serotonin 2B Receptor Dependent Mechanism.

Human PAH is characterized by a pattern of lipid-related insulin resistance.

Low-grade albuminuria in pulmonary arterial hypertension.

Adverse effects of BMPR2 suppression in macrophages in animal models of pulmonary hypertension.

Machine learning-based microarray analyses indicate low-expression genes might collectively influence PAH disease.

Antagonism of the Thromboxane-Prostanoid Receptor as a Potential Therapy for Cardiomyopathy of Muscular Dystrophy.

Baicalin prevents pulmonary arterial remodeling in vivo via the AKT/ERK/NF-κB signaling pathways.

dysfunction impairs insulin signaling and glucose homeostasis in cardiomyocytes.

Natriuretic peptide receptor C contributes to disproportionate right ventricular hypertrophy in a rodent model of obesity-induced heart failure with preserved ejection fraction with pulmonary hypertension.

A multifaceted investigation into molecular associations of chronic thromboembolic pulmonary hypertension pathogenesis.

Resident mesenchymal vascular progenitors modulate adaptive angiogenesis and pulmonary remodeling via regulation of canonical Wnt signaling.

Expression of a Human Caveolin-1 Mutation in Mice Drives Inflammatory and Metabolic Defect-Associated Pulmonary Arterial Hypertension.