Lingfeng Qin

Smooth Muscle Cell Reprogramming in Aortic Aneurysms.

Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation.

Induction of indoleamine 2,3-dioxygenase in vascular smooth muscle cells by interferon-gamma contributes to medial immunoprivilege.

MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries.

Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection.

JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1.

IFN-gamma primes intact human coronary arteries and cultured coronary smooth muscle cells to double-stranded RNA- and self-RNA-induced inflammatory responses by upregulating TLR3 and melanoma differentiation-associated gene 5.

Sonic hedgehog signaling induces vascular smooth muscle cell proliferation via induction of the G1 cyclin-retinoblastoma axis.

CXCR3-dependent accumulation and activation of perivascular macrophages is necessary for homeostatic arterial remodeling to hemodynamic stresses.

AIP1 prevents graft arteriosclerosis by inhibiting interferon-γ-dependent smooth muscle cell proliferation and intimal expansion.

Transforming growth factor beta expression by human vascular cells inhibits interferon gamma production and arterial media injury by alloreactive memory T cells.

Activation of human vascular cells decreases their expression of transforming growth factor-beta.

FGF regulates TGF-β signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression.

AIP1 suppresses atherosclerosis by limiting hyperlipidemia-induced inflammation and vascular endothelial dysfunction.

Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells.

Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency.

SOCS1 prevents graft arteriosclerosis by preserving endothelial cell function.

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.

Rapamycin antagonizes TNF induction of VCAM-1 on endothelial cells by inhibiting mTORC2.

The docking protein FRS2α is a critical regulator of VEGF receptors signaling.

Interacting mechanisms in the pathogenesis of cardiac allograft vasculopathy.

Fibroblast growth factor receptor 1 is a key inhibitor of TGFβ signaling in the endothelium.

Complement membrane attack complexes activate noncanonical NF-κB by forming an Akt+ NIK+ signalosome on Rab5+ endosomes.

Interferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murine transplant recipients.

Endothelial-to-mesenchymal transition drives atherosclerosis progression.

SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression.

Blocking MHC class II on human endothelium mitigates acute rejection.

Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression.

Implantable tissue-engineered blood vessels from human induced pluripotent stem cells.

Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation.

Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFβ)-dependent smooth muscle cell phenotype modulation.

Inhibition of the mTOR pathway in abdominal aortic aneurysm: implications of smooth muscle cell contractile phenotype, inflammation, and aneurysm expansion.

Deficient Circumferential Growth Is the Primary Determinant of Aortic Obstruction Attributable to Partial Elastin Deficiency.

The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis.

Improving in vivo outcomes of decellularized vascular grafts via incorporation of a novel extracellular matrix.

mTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice.

SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling.

Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells.

Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering.

Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells.

AIP1 Suppresses Transplant Arteriosclerosis Through Inhibition of Vascular Smooth Muscle Cell Inflammatory Response to IFNγ.

ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes.

Complement Membrane Attack Complexes Assemble NLRP3 Inflammasomes Triggering IL-1 Activation of IFN-γ-Primed Human Endothelium.

Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis.

Endothelial Cell-Derived Interleukin-18 Released During Ischemia Reperfusion Injury Selectively Expands T Peripheral Helper Cells to Promote Alloantibody Production.

Tissue-Engineered Vascular Grafts with Advanced Mechanical Strength from Human iPSCs.

Complement-activated interferon-γ-primed human endothelium transpresents interleukin-15 to CD8+ T cells.

H19/TET1 axis promotes TGF-β signaling linked to endothelial-to-mesenchymal transition.

Caveolae-mediated Tie2 signaling contributes to CCM pathogenesis in a brain endothelial cell-specific Pdcd10-deficient mouse model.

CCM3 Loss-Induced Lymphatic Defect Is Mediated by the Augmented VEGFR3-ERK1/2 Signaling.

Hexarelin attenuates abdominal aortic aneurysm formation by inhibiting SMC phenotype switch and inflammasome activation.

Readily Available Tissue-Engineered Vascular Grafts Derived From Human Induced Pluripotent Stem Cells.

FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis.