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Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model

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08:51 min

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November 11th, 2022

DOI :

10.3791/63839-v

November 11th, 2022

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1,257 Views

Lingfeng Qin¹, Bo Jiang², Krisztina Zsebo³, Henricus J. Duckers³, Michael Simons⁴^,⁵, Pei-Yu Chen⁴

¹Department of Surgery, Yale University School of Medicine, ²Department of Vascular Surgery, The First Hospital of China Medical University, Key Laboratory of Pathogenesis, Prevention, and Therapeutics of Aortic Aneurysm, ³VasoRx Inc., ⁴Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, ⁵Department of Cell Biology, Yale University School of Medicine

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Intravenous Bolus Dosing

Invasive Hemodynamic Assessment

Hypoxia induced Pulmonary Artery Hypertension

Mouse Model

Jugular Vein Injection

Arterial Catheterization

Right Ventricular Catheterization

Blood Pressure Measurement

Drug Development

Compound Screening

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