Cam Patterson

A new gun in town: the U box is a ubiquitin ligase domain.

Postischemic recovery of contractile function is impaired in SOD2(+/-) but not SOD1(+/-) mouse hearts.

Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy.

Things have changed: cell cycle dysregulation and smooth muscle cell dysfunction in atherogenesis.

A noncoding RNA regulates human protease-activated receptor-1 gene during embryogenesis.

Tiny dancers: the integrin-growth factor nexus in angiogenic signaling.

Protein quality control: U-box-containing E3 ubiquitin ligases join the fold.

Mitochondrial integrity and function in atherogenesis.

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu.

HIV therapies and atherosclerosis: answers or questions?

Welcome to the machine: a cardiologist's introduction to protein folding and degradation.

Evidence for association of coronary sinus levels of hepatocyte growth factor and collateralization in human coronary disease.

Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol.

C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation.

Break the cycle: the role of cell-cycle modulation in the prevention of vasculoproliferative diseases.

Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling.

AtCHIP, a U-box-containing E3 ubiquitin ligase, plays a critical role in temperature stress tolerance in Arabidopsis.

Thrombin and vascular development: a sticky subject.

The Ponzo effect: endothelial progenitor cells appear on the horizon.

Overexpression of the cochaperone CHIP enhances Hsp70-dependent folding activity in mammalian cells.

BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation.

HoxB5 is an upstream transcriptional switch for differentiation of the vascular endothelium from precursor cells.

Chaperone-dependent regulation of endothelial nitric-oxide synthase intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP.

CHIP activates HSF1 and confers protection against apoptosis and cellular stress.

PDTC, metal chelating compound, induces G1 phase cell cycle arrest in vascular smooth muscle cells through inducing p21Cip1 expression: involvement of p38 mitogen activated protein kinase.

Catecholamine-induced vascular wall growth is dependent on generation of reactive oxygen species.

Age-related changes in matrix metalloproteinase-9 regulation in cultured mouse aortic smooth muscle cells.

p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation.

Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein.

Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation.

Younger than yesterday: is vascular senescence a two-way street?

An androgen receptor NH2-terminal conserved motif interacts with the COOH terminus of the Hsp70-interacting protein (CHIP).

CHIP: a link between the chaperone and proteasome systems.

LE-PAS, a novel Arnt-dependent HLH-PAS protein, is expressed in limbic tissues and transactivates the CNS midline enhancer element.

Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.

Universal mouse reference RNA derived from neonatal mice.

Atrogin-1/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex.

Blood pressure control goes nuclear.

A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.

Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy.

Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I.

A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase.

CHIP, a cochaperone/ubiquitin ligase that regulates protein quality control, is required for maximal cardioprotection after myocardial infarction in mice.

Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes.

Differential activation of mitogenic signaling pathways in aortic smooth muscle cells deficient in superoxide dismutase isoforms.

The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways.

Cystic fibrosis transmembrane conductance regulator as a model substrate to study endoplasmic reticulum protein quality control in mammalian cells.

C-terminus of heat shock protein 70-interacting protein facilitates degradation of apoptosis signal-regulating kinase 1 and inhibits apoptosis signal-regulating kinase 1-dependent apoptosis.

Mechanisms of endothelial differentiation in embryonic vasculogenesis.

Even flow: shear cues vascular development.

Regulation of the cytoplasmic quality control protein degradation pathway by BAG2.

Direct identification of ubiquitination sites on ubiquitin-conjugated CHIP using MALDI mass spectrometry.

Bone morphogenetic proteins and vascular differentiation: BMPing up vasculogenesis.

Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP.

ATP stimulates MMP-2 release from human aortic smooth muscle cells via JNK signaling pathway.

A combined strategy to reduce restenosis for vascular tissue engineering applications.

The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones.

Abciximab-associated thrombocytopenia after previous tirofiban-related thrombocytopenia.

A salty salute: progenitor cell therapies and no-option heart disease.

Search and destroy: the role of protein quality control in maintaining cardiac function.

CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70.

Gene expression profile signatures indicate a role for Wnt signaling in endothelial commitment from embryonic stem cells.

Comparative effects of paclitaxel and rapamycin on smooth muscle migration and survival: role of AKT-dependent signaling.

Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.

CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation.

Ubiquitin-proteasome degradation of serum- and glucocorticoid-regulated kinase-1 (SGK-1) is mediated by the chaperone-dependent E3 ligase CHIP.

Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator.

Down-regulation of the mixed-lineage dual leucine zipper-bearing kinase by heat shock protein 70 and its co-chaperone CHIP.

Into the heart: the emerging role of the ubiquitin-proteasome system.

Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies.

Gene expression profiles identify a role for cyclooxygenase 2-dependent prostanoid generation in BMP6-induced angiogenic responses.

Brain CHIP: removing the culprits in neurodegenerative disease.

2-methoxyestradiol inhibits the anaphase-promoting complex and protein translation in human breast cancer cells.

Muscle ring finger 1, but not muscle ring finger 2, regulates cardiac hypertrophy in vivo.

The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.

CHIP and HSPs interact with beta-APP in a proteasome-dependent manner and influence Abeta metabolism.

The bitter end: the ubiquitin-proteasome system and cardiac dysfunction.

Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury.

Chaperone functions of the E3 ubiquitin ligase CHIP.

Characterization of a model to independently study regression of ventricular hypertrophy.

BMPER is a conserved regulator of hematopoietic and vascular development in zebrafish.

ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.

Selection and initial characterization of novel peptide ligands that bind specifically to human blood outgrowth endothelial cells.

PRDM6 is enriched in vascular precursors during development and inhibits endothelial cell proliferation, survival, and differentiation.

ERK signaling is a central regulator for BMP-4 dependent capillary sprouting.

Chaperone-dependent E3 ligase CHIP ubiquitinates and mediates proteasomal degradation of soluble guanylyl cyclase.

Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins.

Twin layers of lightning: a new role for the chaperone Hsp90 in angiogenesis.

The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle.

CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden.

Sequential roles for myosin-X in BMP6-dependent filopodial extension, migration, and activation of BMP receptors.

Partners in crime: how two Sox proteins cooperate to specify arterial fate.

You spin me round: MaFBx/Atrogin-1 feeds forward on FOXO transcription factors (like a record).

Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure.

Akt and CHIP coregulate tau degradation through coordinated interactions.

Molecular characterization of human breast tumor vascular cells.

CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control.

The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching.

Selective endothelial cell attachment to peptide-modified terpolymers.

Therapeutic options for premature coronary artery disease.

Tobacco use induces anti-apoptotic, proliferative patterns of gene expression in circulating leukocytes of Caucasian males.

BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis.

Zinc fingers in the pizza pie aorta.

CRAF autophosphorylation of serine 621 is required to prevent its proteasome-mediated degradation.

Brothers and sisters: molecular insights into arterial-venous heterogeneity.

Build it up-Tear it down: protein quality control in the cardiac sarcomere.

The opening act: vasculogenesis and the origins of circulation.

Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2.

CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.

Regression of pressure-induced left ventricular hypertrophy is characterized by a distinct gene expression profile.

Muscle ring finger 1 mediates cardiac atrophy in vivo.

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity.

Torturing a blood vessel.

A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling.

CHIP represses myocardin-induced smooth muscle cell differentiation via ubiquitin-mediated proteasomal degradation.

Breast cancer quality control.

SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration.

New insights into bone morphogenetic protein signaling: focus on angiogenesis.

HoxB5 induces endothelial sprouting in vitro and modifies intussusceptive angiogenesis in vivo involving angiopoietin-2.

Black and white: rapamycin as a regulator of cardiac mTOR signaling.

Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway.

Stress-dependent Daxx-CHIP interaction suppresses the p53 apoptotic program.

C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1.

Cardiac muscle ring finger-1 increases susceptibility to heart failure in vivo.

Appetite for destruction: E3 ubiquitin-ligase protection in cardiac disease.

Engineering a ubiquitin ligase reveals conformational flexibility required for ubiquitin transfer.

Krüppel-like factor 15 regulates BMPER in endothelial cells.

Seek and destroy: the ubiquitin----proteasome system in cardiac disease.

Minireview: Won't get fooled again: the nonmetabolic roles of peroxisome proliferator-activated receptors (PPARs) in the heart.

Stable patterns of gene expression regulating carbohydrate metabolism determined by geographic ancestry.

BMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1.

Hard luck stories: the reality of endothelial progenitor cells continues to fall short of the promise.

The FoxO family in cardiac function and dysfunction.

Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease.

Gyrate: CCM3 dances with a different angiogenic partner.

Development of the endothelium: an emphasis on heterogeneity.

A good idea: a physician's perspective on genetic counseling for hypertrophic cardiomyopathy.

mTORC1 links protein quality and quantity control by sensing chaperone availability.

Cardiac muscle ring finger-1--friend or foe?

Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.

Closer to fine: fewer steps to endothelial stemness.

C-terminus of heat shock protein 70-interacting protein-dependent GTP cyclohydrolase I degradation in lambs with increased pulmonary blood flow.

CHIP-dependent p53 regulation occurs specifically during cellular senescence.

Hold me tight: Role of the heat shock protein family of chaperones in cardiac disease.

Recombinant human interleukin-11 treatment enhances collateral vessel growth after femoral artery ligation.

Evaluating age-associated phenotypes in a mouse model of protein dyshomeostasis.

Regulation of AMPK by the ubiquitin proteasome system.

Tearin' up my heart: proteolysis in the cardiac sarcomere.

Efficient in vivo selection of a novel tumor-associated peptide from a phage display library.

The ubiquitin ligase MuRF1 protects against cardiac ischemia/reperfusion injury by its proteasome-dependent degradation of phospho-c-Jun.

NF-κB inhibition protects against tumor-induced cardiac atrophy in vivo.

Regulation of ankyrin repeat and suppressor of cytokine signalling box protein 4 expression in the immortalized murine endothelial cell lines MS1 and SVR: a role for tumour necrosis factor alpha and oxygen.

The role of calcineurin/NFAT in SFRP2 induced angiogenesis--a rationale for breast cancer treatment with the calcineurin inhibitor tacrolimus.

Rise above: muscle ring-finger-1 (MURF1) regulation of cardiomyocyte size and energy metabolism.

Bone morphogenetic protein endothelial cell precursor-derived regulator regulates retinal angiogenesis in vivo in a mouse model of oxygen-induced retinopathy.

Tear me down: role of calpain in the development of cardiac ventricular hypertrophy.

Regulation of the calpain and ubiquitin-proteasome systems in a canine model of muscular dystrophy.

Reconstitution of CHIP E3 ubiquitin ligase activity.

BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium.

Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation.

Back to your heart: ubiquitin proteasome system-regulated signal transduction.

BMPER protein is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic mice.

Life is a pattern: vascular assembly within the embryo.

The expanding world of post-translational modifications.

p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.

A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting.

Recovery from decompensated heart failure is associated with a distinct, phase-dependent gene expression profile.

The ubiquitin-proteasome system and cardiovascular disease.

Bmper inhibits endothelial expression of inflammatory adhesion molecules and protects against atherosclerosis.

LRP1-dependent endocytic mechanism governs the signaling output of the bmp system in endothelial cells and in angiogenesis.

PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response.

Guidelines for the use and interpretation of assays for monitoring autophagy.

Lysine 48-linked polyubiquitination of organic anion transporter-1 is essential for its protein kinase C-regulated endocytosis.

ARID1a-DNA interactions are required for promoter occupancy by SWI/SNF.

BMPER regulates cardiomyocyte size and vessel density in vivo.

Proteotoxicity and cardiac dysfunction--Alzheimer's disease of the heart?

Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1-mediated gene expression in vivo.

Carboxyl terminus of Hsp70-interacting protein (CHIP) is required to modulate cardiac hypertrophy and attenuate autophagy during exercise.

A novel monoclonal antibody to secreted frizzled-related protein 2 inhibits tumor growth.

Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response.

Proteotoxicity and cardiac dysfunction.

Antagonism and synergy between extracellular BMP modulators Tsg and BMPER to balance blood vessel formation.

Development of a new positron emission tomography tracer for targeting tumor angiogenesis: synthesis, small animal imaging, and radiation dosimetry.

Diggin' on U(biquitin): A Novel Method for the Identification of Physiological E3 Ubiquitin Ligase Substrates.

Inhibition of BMP activity protects epithelial barrier function in lung injury.