Stephen C. Harrison

Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1.

Structure of the reovirus membrane-penetration protein, Mu1, in a complex with is protector protein, Sigma3.

Don C. Wiley (1944-2001).

Don C. Wiley (1944--2001).

The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site.

Atomic model of the papillomavirus capsid.

Specificity and affinity of sialic acid binding by the rhesus rotavirus VP8* core.

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.

RNA synthesis in a cage--structural studies of reovirus polymerase lambda3.

How does radiation damage in protein crystals depend on X-ray dose?

Variation on an Src-like theme.

Disulfide bonding among micro 1 trimers in mammalian reovirus outer capsid: a late and reversible step in virion morphogenesis.

A ligand-binding pocket in the dengue virus envelope glycoprotein.

An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site.

Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII.

Two distinct size classes of immature and mature subviral particles from tick-borne encephalitis virus.

X-ray structure of a protein-conducting channel.

Whither structural biology?

Structure of the dengue virus envelope protein after membrane fusion.

Structure of the human transferrin receptor-transferrin complex.

Orthoreovirus and Aquareovirus core proteins: conserved enzymatic surfaces, but not protein-protein interfaces.

A chimeric protein of simian immunodeficiency virus envelope glycoprotein gp140 and Escherichia coli aspartate transcarbamoylase.

Full-length influenza hemagglutinin HA2 refolds into the trimeric low-pH-induced conformation.

Discovery of antivirals against smallpox.

Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation.

Structural rearrangements in the membrane penetration protein of a non-enveloped virus.

Crystal structure of the clathrin adaptor protein 1 core.

Molecular model for a complete clathrin lattice from electron cryomicroscopy.

Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating.

Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer.

Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.

Crystal structure of the spindle assembly checkpoint protein Bub3.

Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein.

The yeast DASH complex forms closed rings on microtubules.

Determining the structure of an unliganded and fully glycosylated SIV gp120 envelope glycoprotein.

Structure of an unliganded simian immunodeficiency virus gp120 core.

Molecular organization of the Ndc80 complex, an essential kinetochore component.

The active conformation of the PAK1 kinase domain.

Mechanism of membrane fusion by viral envelope proteins.

Structure of SARS coronavirus spike receptor-binding domain complexed with receptor.

Features of reovirus outer capsid protein mu1 revealed by electron cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom resolution.

Lipid-protein interactions in double-layered two-dimensional AQP0 crystals.

SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells.

Single particle reconstructions of the transferrin-transferrin receptor complex obtained with different specimen preparation techniques.

Single particle reconstruction of the human apo-transferrin-transferrin receptor complex.

Stu2p binds tubulin and undergoes an open-to-closed conformational change.

Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain.

Conformational states of the severe acute respiratory syndrome coronavirus spike protein ectodomain.

Crystal structure of glycoprotein B from herpes simplex virus 1.

Structure determination of clathrin coats to subnanometer resolution by single particle cryo-electron microscopy.

Small molecules that bind the inner core of gp41 and inhibit HIV envelope-mediated fusion.

Reovirus mu1 structural rearrangements that mediate membrane penetration.

Restraining the conformation of HIV-1 gp120 by removing a flexible loop.

Interactions between SARS coronavirus and its receptor.

Cryo-electron tomography of clathrin-coated vesicles: structural implications for coat assembly.

The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment.

Structural analysis of Bub3 interactions in the mitotic spindle checkpoint.

Crystal structure of a TOG domain: conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding.

Protein arms in the kinetochore-microtubule interface of the yeast DASH complex.

Structure of calcineurin in complex with PVIVIT peptide: portrait of a low-affinity signalling interaction.

Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch.

An atomic model of the interferon-beta enhanceosome.

Structure and function of an essential component of the outer membrane protein assembly machine.

Interactions of lipids with aquaporin-0 and other membrane proteins.

Comments on the NIGMS PSI.

Crystal structure of the yeast inner kinetochore subunit Cep3p.

Three-dimensional intricacies in protein-DNA recognition and transcriptional control.

XMAP215 is a processive microtubule polymerase.

Near-atomic resolution using electron cryomicroscopy and single-particle reconstruction.

Peptides released from reovirus outer capsid form membrane pores that recruit virus particles.

Viral membrane fusion.

Single-particle kinetics of influenza virus membrane fusion.

The pH sensor for flavivirus membrane fusion.

Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1.

Requirements for the formation of membrane pores by the reovirus myristoylated micro1N peptide.

Molecular interactions in rotavirus assembly and uncoating seen by high-resolution cryo-EM.

Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab.

VP5* rearranges when rotavirus uncoats.

Role of HIV membrane in neutralization by two broadly neutralizing antibodies.

A rotavirus spike protein conformational intermediate binds lipid bilayers.

Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly.

X-ray crystal structure of the rotavirus inner capsid particle at 3.8 A resolution.

Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses.

Subunit interactions in bovine papillomavirus.

Effect of mutations in VP5 hydrophobic loops on rotavirus cell entry.

Peptide inhibitors of dengue-virus entry target a late-stage fusion intermediate.

Analysis of kinetic intermediates in single-particle dwell-time distributions.

CLASP promotes microtubule rescue by recruiting tubulin dimers to the microtubule.

The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments.

Structural biology: Conservation in vesicle coats.

Virology. Looking inside adenovirus.

Structure of the PTEN-like region of auxilin, a detector of clathrin-coated vesicle budding.

Peptide inhibitors of flavivirus entry derived from the E protein stem.

Structural analysis of the interaction between Dishevelled2 and clathrin AP-2 adaptor, a critical step in noncanonical Wnt signaling.

Mechanistic biology in the next quarter century.

Atomic model of an infectious rotavirus particle.

Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating.

Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy.

Recognition of the centromere-specific histone Cse4 by the chaperone Scm3.

Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching.

Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin.

Cross-linking of rotavirus outer capsid protein VP7 by antibodies or disulfides inhibits viral entry.

Ndc10 is a platform for inner kinetochore assembly in budding yeast.

RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure.