Silvia Muro

ICAM-directed vascular immunotargeting of antithrombotic agents to the endothelial luminal surface.

A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1.

Immunotargeting of catalase to the pulmonary endothelium alleviates oxidative stress and reduces acute lung transplantation injury.

Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress.

Characterization of endothelial internalization and targeting of antibody-enzyme conjugates in cell cultures and in laboratory animals.

Endothelial endocytic pathways: gates for vascular drug delivery.

ICAM-1 recycling in endothelial cells: a novel pathway for sustained intracellular delivery and prolonged effects of drugs.

Lysosomal enzyme delivery by ICAM-1-targeted nanocarriers bypassing glycosylation- and clathrin-dependent endocytosis.

Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ exchanger proteins.

Endothelial targeting of high-affinity multivalent polymer nanocarriers directed to intercellular adhesion molecule 1.

Advanced drug delivery systems that target the vascular endothelium.

In vivo imaging of 64Cu-labeled polymer nanoparticles targeted to the lung endothelium.

RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1.

Delivery of acid sphingomyelinase in normal and niemann-pick disease mice using intercellular adhesion molecule-1-targeted polymer nanocarriers.

Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers.

Differential intra-endothelial delivery of polymer nanocarriers targeted to distinct PECAM-1 epitopes.

Oxygen microscopy by two-photon-excited phosphorescence.

Flow dynamics, binding and detachment of spherical carriers targeted to ICAM-1 on endothelial cells.

New biotechnological and nanomedicine strategies for treatment of lysosomal storage disorders.

Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers.

Enhanced endothelial delivery and biochemical effects of α-galactosidase by ICAM-1-targeted nanocarriers for Fabry disease.

Endothelial targeting of antibody-decorated polymeric filomicelles.

Enhanced delivery of α-glucosidase for Pompe disease by ICAM-1-targeted nanocarriers: comparative performance of a strategy for three distinct lysosomal storage disorders.

Effect of flow on endothelial endocytosis of nanocarriers targeted to ICAM-1.

A fibrinogen-derived peptide provides intercellular adhesion molecule-1-specific targeting and intraendothelial transport of polymer nanocarriers in human cell cultures and mice.

Intercellular adhesion molecule 1 engagement modulates sphingomyelinase and ceramide, supporting uptake of drug carriers by the vascular endothelium.

Effect of thiol pendant conjugates on plasmid DNA binding, release, and stability of polymeric delivery vectors.

Endothelial targeting of polymeric nanoparticles stably labeled with the PET imaging radioisotope iodine-124.

Effect of Glycocalyx on Drug Delivery Carriers Targeted to Endothelial Cells.

Transport of nanocarriers across gastrointestinal epithelial cells by a new transcellular route induced by targeting ICAM-1.

Challenges in design and characterization of ligand-targeted drug delivery systems.

Biodistribution and endocytosis of ICAM-1-targeting antibodies versus nanocarriers in the gastrointestinal tract in mice.

Acute and chronic shear stress differently regulate endothelial internalization of nanocarriers targeted to platelet-endothelial cell adhesion molecule-1.

Comparative binding, endocytosis, and biodistribution of antibodies and antibody-coated carriers for targeted delivery of lysosomal enzymes to ICAM-1 versus transferrin receptor.

In vivo performance of polymer nanocarriers dually-targeted to epitopes of the same or different receptors.

Investigating polymer thiolation in gene delivery.