Stephen Loukin

Carboxyl tail prevents yeast K(+) channel closure: proposal of an integrated model of TOK1 gating.

The carboxyl tail forms a discrete functional domain that blocks closure of the yeast K+ channel.

The transient receptor potential channel on the yeast vacuole is mechanosensitive.

Microbial K+ channels.

Prokaryotic K(+) channels: from crystal structures to diversity.

Lipid perturbations sensitize osmotic down-shock activated Ca2+ influx, a yeast "deletome" analysis.

Yeast screens show aromatic residues at the end of the sixth helix anchor transient receptor potential channel gate.

Yeast gain-of-function mutations reveal structure-function relationships conserved among different subfamilies of transient receptor potential channels.

A genome-wide survey suggests an osmoprotective role for vacuolar Ca2+ release in cell wall-compromised yeast.

Indole and other aromatic compounds activate the yeast TRPY1 channel.

Hypotonic shocks activate rat TRPV4 in yeast in the absence of polyunsaturated fatty acids.

Mechanical force and cytoplasmic Ca(2+) activate yeast TRPY1 in parallel.

The use of yeast to understand TRP-channel mechanosensitivity.

Forward genetic analysis reveals multiple gating mechanisms of TRPV4.

Wild-type and brachyolmia-causing mutant TRPV4 channels respond directly to stretch force.

Increased basal activity is a key determinant in the severity of human skeletal dysplasia caused by TRPV4 mutations.